Pharmacy and Pharmaceutical Sciences Commons^™

Effects Of Compaction Pressure, Speed And Punch Head Profile On The Ultrasonically-Extracted Physical Properties Of Pharmaceutical Compacts, Xiaochi Xu, Yigitcan Coskunturk, Vivek S. Dave, Justin V. Kuriyilel, Murray F. Wright, Rutesh H. Dave, Centin Cetinkaya

Pharmacy Faculty/Staff Publications

Despite a well-established manufacturing-process understanding, tablet quality issues are frequently encountered during various stages of drug-product development. Compact breaking force (tensile strength), capping and friability are among the commonly observed characteristics that determine the integrity, quality and manufacturability of tablets. In current study, a design space of the compaction pressure, compaction speed and head flat types is introduced for solid dosage compacts prepared from pure silicified microcrystalline cellulose, a popular tableting excipient. In the reported experiments, five types of head flat types at six compaction pressure levels and two compaction speeds were employed and their effects on compact mechanical properties …

A Review Of The Food And Drug Administration Adverse Event Reporting System For Tramadol-Related Hypoglycemia, Katherine Juba, Robbert Van Manen, Shawn E. Fellows

Pharmacy Faculty/Staff Publications

Background: Hypoglycemia is a rare adverse effect of tramadol that is described in the medical literature and package insert. Objective: The purpose of this study was to review reports of tramadol and hypoglycemia in the Food and Drug Administration Adverse Event Reporting System (FAERS) database to determine a potential association. Methods: Disproportionality analysis with Bayesian correction was used to compare tramadol and hypoglycemia with other medications in FAERS. The results were considered significant if the fifth percentile of the Empirical Bayesian geometric mean distribution (EB05) >2. Logistic regression odds ratios was used to determine if age, diabetes medications, and renal …

A Systematic Review Of The Evidence Behind Use Of Reduced Doses Of Acetaminophen In Chronic Liver Disease, Anne Schweighardt, Katherine Juba

Pharmacy Faculty/Staff Publications

Acetaminophen is among the most commonly used nonopioid analgesics, but significant variation exists in its prescribing practices for cirrhosis patients. Our primary objective was to describe the quality of evidence supporting or refuting the use of acetaminophen in patients with hepatic dysfunction. A comprehensive literature review of PubMed, Cochrane Library, Web of Science, and International Pharmaceutical Abstracts using the search terms “acetaminophen,” “paracetamol,” “chronic liver disease,” “cirrhosis,” and “hepatic disease” for studies describing changes in acetaminophen metabolism in patients with hepatic dysfunction was conducted. Twelve studies and four abstracts were included. Ten studies and three abstracts were pharmacokinetic studies. Two …

Pharmacy Students’ Attitudes And Perceptions Toward Pharmacogenomics Education, Shanice Coriolan, Nimota Arikawe, Arden Moscati, Lisheng Zhou, Stephanie Dym, Seda Donmez, Adinoyi Garba, Sahsa Falbaum, Zvi Loewy, Melinda E. Lull, Maha Saad, Jane Shtaynberg, Aniwaa Owusu Obeng

Pharmacy Faculty/Staff Publications

Purpose

To evaluate final-year pharmacy students’ perceptions toward pharmacogenomics education, their attitudes on its clinical relevance, and their readiness to use such knowledge in practice.

Methods

A 19-question survey was developed and modified from prior studies and was pretested on a small group of pharmacogenomics faculty and pharmacy students. The final survey was administered to 978 final-year pharmacy students in 8 school/colleges of pharmacy in New York and New Jersey between January and May 2017. The survey targeted 3 main themes: perceptions toward pharmacogenomics education, attitudes toward the clinical relevance of this education, and the students’ readiness to use knowledge …