Pharmacy and Pharmaceutical Sciences Commons^™

Stability Of Diluted Adenosine Solutions In Polyvinyl Chloride Infusion Bags, Melissa Kaltenbach, David Hutchinson, Jessica E. Bollinger, Fang Zhao

Doctoral External Publications

Purpose The stability of diluted adenosine solutions in polyvinyl chloride infusion bags was studied.

Methods Adenosine 50-, 100-, and 220-μg/mL solutions were prepared in 50-mL polyvinyl chloride (PVC) infusion bags containing 0.9% sodium chloride injection or 5% dextrose injection and stored at room temperature (23–25 °C) or under refrigeration (2–8 °C). Each sample of every combination of concentration, diluent, and storage temperature was prepared in triplicate, yielding 36 samples. The samples were assayed using a stability-indicating, reverse-phase high-performance liquid chromatographic method immediately after preparation (time zero) and at 24 hours, 48 hours, 7 days, and 14 days. pH was measured …

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size And Microglial Number In Happ(751)Sl Mice, Melinda E. Lull, Shannon Levesque,, Michael J. Surace, Michelle L. Block

Pharmacy Faculty/Staff Publications

Background: NADPH oxidase is implicated in neurotoxic microglial activation and the progressive nature of Alzheimer’s Disease (AD). Here, we test the ability of two NADPH oxidase inhibitors, apocynin and dextromethorphan (DM), to reduce learning deficits and neuropathology in transgenic mice overexpressing human amyloid precursor protein with the Swedish and London mutations (hAPP(751)SL).

Methods: Four month old hAPP(751)SL mice were treated daily with saline, 15 mg/kg DM, 7.5 mg/kg DM, or 10 mg/kg apocynin by gavage for four months.

Results: Only hAPP(751)SL mice treated with apocynin showed reduced plaque size and a reduction in the number of cortical microglia, when compared …

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation Of Dopaminergic Neurotoxicity, Shannon Levesque, Thomas Taetzsch, Melinda E. Lull, Urmila Kodavanti, Krisztian Stadler, Alison Wagner, Jo Anne Johnson, Laura Duke, Prasada Kodavanti, Michael J. Surace, Michelle L. Block

Pharmacy Faculty/Staff Publications

BACKGROUND:

Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood.

OBJECTIVES:

Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms underlying DE-induced microglia activation, neuroinflammation, and dopaminergic (DA) neurotoxicity.

METHODS:

Rats were exposed to DE (2.0, 0.5, and 0 mg/m3) by inhalation over 4 weeks or as a single intratracheal administration of DE particles (DEP; 20 mg/kg). Primary neuron-glia cultures and the HAPI (highly aggressively proliferating immortalized) microglial cell line were used to explore cellular mechanisms.

RESULTS:

Rats exposed to DE by inhalation demonstrated elevated levels …

The Need For Transgender Health Content In The Pharmacy Curriculum, Jennifer Mathews, Amy L. Parkhill, Jeanne Gainsburg, Scott Fearing

Pharmacy Faculty/Staff Publications

The article, “The Need for Transgender Health Content in the Pharmacy Curriculum,” addresses transgender patients and how they often have complex medical, psychological, and social concerns. According to the article, these patients may not only need to learn to manage complicated medication regimens, which can have significant side effects, but may also face many barriers to treatment. Some of those barriers include difficulties with insurance, fear of discrimination, lack of support, and a mistrust of the healthcare system. Given the important role that medications play in maintaining their quality of life, the article suggests that pharmacists are in a unique …

Lecture Podcasts--Supplement Or Replacement For In-Class Lectures In Traditional Classroom Courses?, Parag Budukh, Christine R. Birnie

Pharmacy Faculty/Staff Publications

No abstract provided.

The Design Of A Sterile Product Laboratory Module As Preparation For An Institutional Ippe Course, Fang Zhao, Christine R. Birnie, Anthony Corigliano, Susan Hughes, John Loughner, Stephen Valentine

Pharmacy Faculty/Staff Publications

Objectives: To develop a pharmaceutics laboratory module on compounded sterile products for the second year pharmacy students as preparation for an institutional pharmacy experiential course. Method: A 5-week lab module was designed and implemented as part of the Pharmaceutics Lab Course to provide training in the basic skills of sterile product compounding. The module included techniques in the handling of sterile products, aseptic techniques, medium risk products, and hazardous products. A practical exam was given at the end of this module to ensure student competency. Upon completion of the lab module, students enrolled in a required 4-week institutional pharmacy experiential …

Anticoagulation Clinic Led By Experiential Education Team, Asim Abu-Baker

Pharmacy Faculty/Staff Publications

No abstract provided.

Evaluation Of Student Performance Using Multiple Choice And Open-Ended Examination Questions In A Pharmacy Calculations Course., Christine R. Birnie, Parag Budukh

Pharmacy Faculty/Staff Publications

No abstract provided.

Increased Hypoglycemia Associated With Renal Failure During Continuous Intravenous Insulin Infusion And Specialized Nutritional Support, Roland N. Dickerson, Leslie A. Hamilton, Kathryn A. Connor, George O. Maish, Martin A. Croce, Gayle Minard, Rex O. Brown

Pharmacy Faculty/Staff Publications

Objective: To evaluate glycemic control for critically ill, hyperglycemic trauma patients with renal failure who received concurrent intensive insulin therapy and continuous enteral (EN) or parenteral nutrition (PN).

Methods: Adult trauma patients with renal failure, who were given EN or PN concurrently with continuous graduated intravenous regular human insulin (RHI) infusion for at least 3 days were evaluated. Our conventional RHI algorithm was modified for those with renal failure by allowing greater changes in blood glucose concentrations (BG) before the infusion rate was escalated. BG was determined every 1-2 hours while receiving the insulin infusion. BG control was evaluated on …

Student-Led Learning In The Pharmaceutical Sciences Curriculum, Melinda E. Lull, Jennifer L. Mathews, E. C. Jannetta, Christine R. Birnie

Pharmacy Faculty/Staff Publications

Objectives: A challenge of primarily didactic courses lies in keeping students engaged in a potentially monotonous learning environment. The objective of this study was to test the effectiveness of incorporating student-led activities into the pharmaceutical sciences curriculum. This alternative approach to traditional lecture-based learning allows for student engagement and ownership of materials. These activities were incorporated into P1 Pharmacology, Biosystems, and Calculations courses.

Methods: A variety of student-led learning activities were conducted in three courses (n=78 students). Following each activity, students were asked to participate in a survey rating the effectiveness, relevancy, productiveness, and overall impression of the activity using …