Pharmacy and Pharmaceutical Sciences Commons^™

Effects Of Fructose-Derived Advanced Glycation End Products On Acetylation Of Histones In The Brain, Alissa K. Cornacchia, Mackenzie Hall, Melinda E. Lull

Undergraduate External Publications

Objective: The objective of this study was to determine the effects of fructose and their advanced glycation end products (fru-AGES) on histone acetylation in microglia, the immune cells of the brain.

Significance: Fru-AGES primarily form as a result of non-enzymatic reactions between fructose and proteins. One result is inflammation in the brain, which can be directly correlated to increased microglia activity. Microglial activity has been shown to be associated with the acetylation of histones, resulting in a change in transcription of inflammatory genes. Elucidation of a direct link between fructose, fru-AGES and histone acetylation would increase understanding the pathophysiology of …