Open Access. Powered by Scholars. Published by Universities.®
Pharmacy and Pharmaceutical Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Bioavailability (1)
- Bioequivalence (1)
- Cutaneous permeation (1)
- Dermal pharmacokinetics (1)
- Direct compression (1)
-
- Dissolution (1)
- Drug-drug cocrystals (1)
- Ex vivo dermal microdialysis (1)
- Fiber-optic dissolution (1)
- IVIVR (1)
- Metformin (1)
- Microdialysis (1)
- Multivariate analysis (1)
- Partial least square regression (1)
- Pharmaceutics (1)
- Pharmacokinetic (1)
- Pharmacokinetics (1)
- Pig study (1)
- Principal component regression (1)
- Structure-mechanical (1)
- Tableting (1)
- Topical dermatological drug products (1)
- UV-visible spectroscopy (1)
Articles 1 - 5 of 5
Full-Text Articles in Pharmacy and Pharmaceutical Sciences
In Vitro And In Silico Approaches To Evaluate The Pharmacokinetics And Pharmacodynamics Of Combination Antibiotic Therapy Against Drug-Resistant Bacteria, Sharmistha Das
Selected Full-Text Dissertations 2020-
This thesis focuses on combating antibacterial resistance by developing novel in vitro and in silico techniques. In vitro techniques such as in vitro pharmacodynamic (IVPD) modeling are powerful tools for investigating pharmacokinetic and pharmacodynamic response of antibiotics against bacteria. The standard IVPD model in the literature works for simulating monotherapy and combination therapy of drugs having similar half live. But it does not work for combination therapy of drugs having different half live. The method present in the literature for combination therapy of drugs with different half live was described by Blaser. By utilizing Blaser’s method, it was observed that …
Multivariate Pharmametric Approach As A Solution To The Challenges Associated With In-Situ Uv Fiber-Optic Dissolution Testing, Rushaben Maulik Sardhara
Multivariate Pharmametric Approach As A Solution To The Challenges Associated With In-Situ Uv Fiber-Optic Dissolution Testing, Rushaben Maulik Sardhara
Selected Full-Text Dissertations 2020-
The advancement and automation in analytical techniques is a current thrust of the pharmaceutical industry. It has been over 30 years since unconventional semi or fully automatic methods have begun to be developed to achieve the measurement in-situ in the dissolution test apparatus. The current study focuses on the fiber optic dissolution system (FODS), its challenges, and solutions to the challenges. The inaccuracy in dissolution profile predictions due to some limitations associated with the FODS makes it difficult to adopt this advanced automated technology for various purposes. The traditional dissolution methods are still widely used even though they are time-consuming …
Ex Vivo Dermis Microdialysis: A Tool For Bioequivalence Testing Of Topical Dermatological Drug Product (Demonstration Of Proof Of Concept And Testing), Mohammad Asif Ali
Ex Vivo Dermis Microdialysis: A Tool For Bioequivalence Testing Of Topical Dermatological Drug Product (Demonstration Of Proof Of Concept And Testing), Mohammad Asif Ali
Selected Full-Text Dissertations 2020-
Clinical response to most topical dermatological drug products (TDDP) depends on the availability of the drug in the dermis. Dermal Microdialysis (dMD) is a sampling technique that permits measuring the concentration of a drug over time, in vivo, directly into the target tissue, the dermis. The pharmacokinetic parameters obtained from such studies may help to optimize the development of TDDP and potentially can be applied to the assessment of TDDP bioequivalence. However, these studies require several hours or even days of continuous sampling that makes it often stressful and unpractical for human subjects as well as animals. The goal of …
Understanding Of The Drug-Drug Co-Crystallized Solid Structure – Mechanical Properties And Improved Tableting Performance Of High Dose Metformin Hci To Optimize The Tablet Size, Jayshil Akhilkumar Bhatt
Understanding Of The Drug-Drug Co-Crystallized Solid Structure – Mechanical Properties And Improved Tableting Performance Of High Dose Metformin Hci To Optimize The Tablet Size, Jayshil Akhilkumar Bhatt
Selected Full-Text Dissertations 2020-
Crystal engineering has been widely explored to design and develop crystalline forms of drugs to address issues related to solubility, permeability, stability, bioavailability, and other properties without impacting the therapeutic efficacy of the drug. In this exploration, we aim to address the existing limitation of metformin HCl (MET) using the cocrystallization technique, an effective tool of crystal engineering. MET, an FDA-approved anti-hyperglycemic drug, is one of the most widely prescribed treatments for type II diabetes mellitus. MET is known to suffer from several limitations due to physicochemical properties and poor mechanical and structural properties, which influence the tableting performance of …
Investigation Of Dermal Bioavailability And Bioequivalence Of Topical Dermatological Drug Products Via Microdialysis In Rabbits, Sharareh Iran Senemar
Investigation Of Dermal Bioavailability And Bioequivalence Of Topical Dermatological Drug Products Via Microdialysis In Rabbits, Sharareh Iran Senemar
Selected Full-Text Dissertations 2020-
There is no standard technique to measure skin pharmacokinetics (PK) and therefore to evaluate bioequivalence (BE) for topical dermatological drug products (TDDPs). Generic companies are required to conduct costly clinical endpoint studies to evaluate BE. For this reason, regulatory agencies are looking for more efficient methods to measure the drug bioavailability of TDDPs. It is about 40 years since microdialysis was developed as a tool to study tissue biochemistry in animals, specifically, neurotransmitter release in the rodent brain, and 30 years since it was applied to study skin PK. However, improvements in the dermal microdialysis (dMD) technique are required to …