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Nanoparticle T Cell Engagers As A Modular Platform For Cancer Immunotherapy, Kinan Alhallak
Nanoparticle T Cell Engagers As A Modular Platform For Cancer Immunotherapy, Kinan Alhallak
McKelvey School of Engineering Theses & Dissertations
Immunotherapy has advanced significantly in recent years due to its promising clinical outcomes in a variety of malignancies and holds great promise in becoming the “cure” for cancer. Cancer immunotherapy is the treatment that stimulates a person’s own immune system to recognize, target, and eliminate cancer cells. As the field progresses with emerging and novel strategies, the ability to manipulate the immune system while mitigating toxicities is the goal for clinical translation. To control for both efficacy and safety, biomaterials have been incorporated into immunotherapies to achieve tissue- and/or cell-specific immunomodulation, overcome immunosuppression, and address tumor microenvironment heterogeneity.T cell-based immunotherapy, …