Pharmacy and Pharmaceutical Sciences Commons^™

Survey Of Childhood Empyema In Asia: Implications For Detecting The Unmeasured Burden Of Culture-Negative Bacterial Disease, Batunkh Nyambat, Paul E. Kilgore, Dong Eun Yong, Dang Duc Anh, Chen-Hsun Chiu, Xuzhuang Shen, Luis Jodar, Timothy L. Ng, Hans L. Bock, William P. Hausdorff

Department of Pharmacy Practice

Background: Parapneumonic empyema continues to be a disease of significant morbidity and mortality among children despite recent advances in medical management. To date, only a limited number of studies have assessed the burden of empyema in Asia.

Methods: We surveyed medical records of four representative large pediatric hospitals in China, Korea, Taiwan and Vietnam using ICD-10 diagnostic codes to identify children < 16 years of age hospitalized with empyema or pleural effusion from 1995 to 2005. We also accessed microbiology records of cultured empyema and pleural effusion specimens to describe the trends in the epidemiology and microbiology of empyema.

Results: During the study period, we identified 1,379 children diagnosed with empyema or pleural effusion (China, n = 461; Korea, n = 134; Taiwan, n = 119; Vietnam, n = 665). Diagnoses of pleural effusion (n = 1,074) …

Transient Acquired Hemophilia Associated With Mycoplasma Pneumoniae Pneumonia, Min Sun Kim, Paul E. Kilgore, Ju Sung Kang, Sun Young Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang

Department of Pharmacy Practice

Acquired hemophilia is a rare disorder caused by autoantibodies to factor VIII (FVIII) (also referred to as factor VIII inhibitors or anti-FVIII) and may be associated with pregnancy, underlying malignancy, or autoimmune disorders. A 33-month-old girl who presented with hematochezia and ecchymotic skin lesions was diagnosed with Mycoplasma pneumoniae pneumonia by serology and polymerase chain reaction. Hematologic studies showed a prolonged activated partial thromboplastin time (aPTT), partially corrected mixing test for aPTT, reduced levels of FVIII, and the presence of antibodies against FVIII. She was treated conservatively with prednisone and intravenous immunoglobulin (IVIG) without FVIII transfusion and recovered without sequelae. …

N-Hexanoyl Chitosan Stabilized Magnetic Nanoparticles: Implication For Cellular Labeling And Magnetic Resonance Imaging, Shanta R. Bhattarai, Remant B. Kc, Sun Y. Kim, Manju Sharma, Myung S. Khil, Pyoung H. Hwang, Gyung H. Chung, Hak Y. Kim

Wayne State University Associated BioMed Central Scholarship

Abstract

This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also …