Pharmacy and Pharmaceutical Sciences Commons^™

Students Attend Prestigious Professional Leadership Conference, Nathan Pilling

News Releases

Three students from Cedarville University’s inaugural Doctor of Pharmacy class recently participated in a distinguished, statewide leadership training conference. Jenna Lawhead, from Saint Petersburg, Fla., Jayson Brewin, from Shamong, N.J., and Allison Henry, from Roseville, Minn., were invited to attend the Ohio Pharmacists Association’s (OPA) Young Pharmacy Leadership Conference held on Sep. 29, 2012 in Columbus, OH.

Pharmacy Professor Collaborates In Valuable Drug Research, Nathan Pilling

News Releases

Natural products make up a sizable portion of the drugs Americans use every day. What makes these products effective? Are there other plants we haven’t discovered yet that could help us control diseases such as cancer and malaria? These are the questions Denise Simpson, Ph.D., is focused on answering through her research.

Asthma Knowledge, Adherence, And Administration Techniques In Hispanic Caregivers Of Pediatrics, Joshua Arnold, Rachel Culp, Kyle Hultz, Benjamin Robertson, Jon Wilkie, Amy Wuobio, Marty L. Eng, Kelly J. Hiteshew

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

7.5% of Hispanics in the United States suffer from asthma-related diseases, and Latino children are not as likely to use preventative asthma medications as compared with Caucasians. Educational interventions may reduce the number of visits to emergency-care. The reasons for non-adherence are currently unknown, and discovering these reasons will help to address the problem.

A Pharmacogenomic And Protein Analysis Of Human Lacrimal Fluid In Varying Age Groups, Jayson M. Brewin, Daniel C. James, Neil B. Klinger, Jenna G. Lawhead, Nathaniel J. Luce, Lindsay N. Florkey, Rocco J. Rotello

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Proteins are large biological molecules located within all cells. They are considered the basic functional components of cells that allow them to operate appropriately. Genes consist of both DNA and RNA, and are the cellular components that code for the proteins. A biomarker is any cellular component that is an indication of a biological state. Therefore, genetic and protein biomarkers are specific genes and proteins, respectively, present in cells that indicate a specific biological state of a cell. Identification of proteins and genetic biomarkers in relative quantities has been found to reflect various disease states and age groups in humans. …

Health Literacy In Community Pharmacy, Sarah Anderson, Cassie Brownfield-Wilson, Kelly Madden, Lindsay Tarleton, Joe Zerka, Aleda M.H. Chen

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

48% of English-speaking patients are unable to obtain, process, understand, and utilize health information, and 30-50% of patients do not correctly adhere to their medications. The combination of chronic disease, poor heath literacy, and poor medication adherence lead to increased health costs and hospitalization

A Review Of Literature Regarding North American Parent’S Perceptions About The Hpv Vaccine And The Effect They Have On Vaccine Uptake In Their Adolescent Daughters Ages 9 To 26, Francesca Couser, Jessica Dahnke

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

A woman dies every 2 minutes due to HPV related illness. Cervical cancer is the 5th most common cancer worldwide, with approximately 471,000 new cases diagnosed each year. There is a decreased risk of HPV related illnesses with vaccine development. However, lack of uptake is suspected to be impacted by parental knowledge deficit. Previously, these illnesses received little attention by parents and healthcare providers, even with the very evident increase in newly diagnosed patients. Without education, rate of infection will continue to increase as vaccine uptake remains stagnant. The purpose of this study is to determine how education from healthcare …

Student Influences In Choosing Pharmacy, Veronica Asomani-Amoah, Kingsley Njangnso, Lauren Petry, Colin Sprague, Molly Turner, Douglas C. Anderson, Jeb Ballentine

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

To determine the race, cultural background, gender, and regional factors on students’ perceptions and influences in choosing pharmacy as a profession on a national scale.

Emergency Contraceptive (Ec) Use In Indigent Populations, Ashley Benjamin, Kasandra Chambers, Melissa Mcnicol, Amy Roy, Kurtis Schultz, April Yoakam, Miriam A. Ansong, Tracy R. Frame

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

The indigent population in America is defined as persons who do not have the financial means to support themselves and are below the federal/state poverty line. According to the 2010 United States Census, 13.8% of Americans are living below the poverty line. Indigent populations often rely on the help of others to provide for their basic needs, whether the help of family and friends or government support. Indigent women are disproportionately affected by unwanted, unplanned pregnancies. It is a continuous cycle that plagues families, often causing poverty and an increased dependence on the welfare system. In Medicaid-eligible populations, many women …

A Comparison Of The Effect Of Intermittent And Continuous Infusion Of Meropenem On The Prevalence Of Nausea In Pediatric Cystic Fibrosis Patients, Marissa Cushing, Juanita A. Draime, Bao-Ngoc Ho, Jordan Nicholls, Bethany Sibbitt, Rebecca Widder, Rebecca J. Gryka, Denise S. Simpson

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Cystic Fibrosis (CF) is a genetic disease, leading to changes of membrane secretions causing obstruction of smaller airways. CF patients often develop pulmonary infections and require antibiotic treatment. Meropenem is a broad spectrum beta lactam that acts by lysing microbes through interfering with bacterial cell wall synthesis. Although a safe and effective treatment, data on pediatric patients is limited.

Improving Medication Safety In An Independent Community Pharmacy, Kacey Adams, Chris Nguyen, Tara Perkins, Laura Richardson, Heather Rose, Jeffrey D. Lewis

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Medication errors are often times thought of as a patient receiving a medication that belongs to another patient, but many to do not understand the other areas that are constituted as “medication errors” are much broader. These errors include, but are not limited to, patient receiving the incorrect medication, improper dosing (too large or too small), wrong drug dispensed, incorrect methods of administration, mislabeling, and etc. Medication errors are such an important issue in the United State because it is the most medicated society in history.

Effects Of Physical Stress And Maturational Changes On Hypothalamic Pituitary Adrenal Axis Function Through Cortisol Analysis, Amy Granger, Allison Henry, Lauren Lilliencrantz, Amanda Smith, Paul Srnis, William Van Schepen, Elisha R. Injeti

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Cortisol is a versatile hormone that possesses both catabolic and anabolic functions in the body, such as increasing the blood glucose levels through gluconeogenesis and metabolizing carbohydrates, proteins, and fats.1234 Cortisol levels are controlled by communication of the hyptothalamic-pituitary-adrenal axix (HPA axis). Plasma concentration of cortisol adheres to a diurnal rhythm, meaning that cortisol levels are highest in the morning and taper off throughout the day.

The Effectiveness Of Lactated Ringers Solution Versus Normal Saline, Danis Davis, Sara Kochanowski

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

In this review of literature we aim to determine which crystalloid solution would be the most beneficial and safe for patients experiencing shock due to hemorrhage and patients undergoing organ transplant or repair. The choice of crystalloid solutions, such as Lactated Ringer’s solution or Normal Saline is under debate as to which should be used during specific scenarios to achieve safe fluid administration.

2012 White Coat Ceremony Program, School Of Pharmacy, Cedarville University

2012 White Coat Ceremony Documents

No abstract provided.

2012 White Coat Ceremony Invitation, School Of Pharmacy, Cedarville University

2012 White Coat Ceremony Documents

No abstract provided.

Pledge Of Professionalism, School Of Pharmacy, Cedarville University

2012 White Coat Ceremony Documents

No abstract provided.

Class Of 2016, School Of Pharmacy, Cedarville University

2012 White Coat Ceremony Documents

No abstract provided.

A Clinically Significant Interaction Between Tacrolimus And Multiple Proton Pump Inhibitors In A Kidney Transplant Recipient, Michelle Maguire, Thaddeus T. Franz, David S. Hains

Pharmacy Practice Faculty Publications

The shared metabolism of PPIs and tacrolimus through the CYP enzyme system has been associated with clinically significant drug interactions, especially in patients who are classified as CYP 2C19 PMs. However, existing data are conflicting, indicating that a single mechanism does not account for all interactions. A drug interaction between tacrolimus and omeprazole, esomeprazole, but not lansoprazole, occurred in an 18-yr-old female kidney transplant recipient classified as a CYP 2C19 extensive (normal) metabolizer. This case suggests that further research is needed to establish the definitive mechanism of this potentially serious drug–drug interaction. Physicians prescribing PPIs in organ transplant recipients with …

A Humanized Pattern Of Aromatase Expression Is Associated With Mammary Hyperplasia In Mice, Hong Zhao, Elizabeth K. Pearson, David C. Brooks, John S. Coon, Dong Chen, Masashi Demura, Ming Zhang, Charles V. Clevenger, Xia Xu, Timothy D. Veenstra, Robert T. Chatterton, Francesco J. Demayo, Serdar E. Bulun

Pharmaceutical Sciences Faculty Publications

Aromatase is essential for estrogen production and is the target of aromatase inhibitors, the most effective endocrine treatment for postmenopausal breast cancer. Peripheral tissues in women, including the breast, express aromatase via alternative promoters. Female mice lack the promoters that drive aromatase expression in peripheral tissues; thus, we generated a transgenic humanized aromatase (Arom(hum)) mouse line containing a single copy of the human aromatase gene to study the link between aromatase expression in mammary adipose tissue and breast pathology. Arom(hum) mice expressed human aromatase, driven by the proximal human promoters II and I.3 and the distal promoter I.4, in breast …

Hormone-Induced 14-3-3Γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity And Steroid Biosynthesis In Ma-10 Leydig Cells, Yasaman Aghazadeh, Malena B. Rone, Josip Blonder, Xiaoying Ye, Timothy D. Veenstra, D. Buck Hales, Martine Culty, Vassilios Papadopoulos

Pharmaceutical Sciences Faculty Publications

Cholesterol is the sole precursor of steroid hormones in the body. The import of cholesterol to the inner mitochondrial membrane, the rate-limiting step in steroid biosynthesis, relies on the formation of a protein complex that assembles at the outer mitochondrial membrane called the transduceosome. The transduceosome contains several mitochondrial and cytosolic components, including the steroidogenic acute regulatory protein (STAR). Human chorionic gonadotropin (hCG) induces de novo synthesis of STAR, a process shown to parallel maximal steroid production. In the hCG-dependent steroidogenic MA-10 mouse Leydig cell line, the 14-3-3γ protein was identified in native mitochondrial complexes by mass spectrometry and immunoblotting, …

Concentration Of Endogenous Estrogens And Estrogen Metabolites In The Nci-60 Human Tumor Cell Lines, Xia Xu, Timothy D. Veenstra

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Endogenous estrogens and estrogen metabolites play an important role in the pathogenesis and development of human breast, endometrial, and ovarian cancers. Increasing evidence also supports their involvement in the development of certain lung, colon and prostate cancers.

METHODS: In this study we systemically surveyed endogenous estrogen and estrogen metabolite levels in each of the NCI-60 human tumor cell lines, which include human breast, central nerve system, colon, ovarian, prostate, kidney and non-small cell lung cancers, as well as melanomas and leukemia. The absolute abundances of these metabolites were measured using a liquid chromatography-tandem mass spectrometry method that has been …

Metabolomics: The Final Frontier?, Timothy D. Veenstra

Pharmaceutical Sciences Faculty Publications

No abstract provided.

Pressure-Assisted Protein Extraction: A Novel Method For Recovering Proteins From Archival Tissue For Proteomic Analysis, Carol B. Fowler, Timothy J. Waybright, Timothy D. Veenstra, Timothy J. O'Leary, Jeffrey T. Mason

Pharmaceutical Sciences Faculty Publications

Formaldehyde-fixed, paraffin-embedded (FFPE) tissue repositories represent a valuable resource for the retrospective study of disease progression and response to therapy. However, the proteomic analysis of FFPE tissues has been hampered by formaldehyde-induced protein modifications, which reduce protein extraction efficiency and may lead to protein misidentification. Here, we demonstrate the use of heat augmented with high hydrostatic pressure (40,000 psi) as a novel method for the recovery of intact proteins from FFPE mouse liver. When FFPE mouse liver was extracted using heat and elevated pressure, there was a 4-fold increase in protein extraction efficiency, a 3-fold increase in the extraction of …

Survey Of Community Pharmacy Customers’ Medication Storage And Disposal Methods, Ryan Biddinger, Laura K. Farleman, Alex Janssen, Mallory J. Martin, Anna M. Staudt, Chelsea Wamsley, Tracy R. Frame

Pharmacy Practice Faculty Presentations

Many people store medications in bathrooms, which provide a moist, humid environment that speeds up the breakdown process of medications. The proper way to store medicines is in a cool, dry place out of the reach of children. Every year medications are also disposed of improperly presenting a risk to both humans and the environment. About one-third of all sold medications are unused. The most common ways patients dispose of medications in the United States are flushing down the toilet or sink, and throwing them away. Because of this pharmaceuticals have been found in groundwater, and drinking water proving hazardous …

Pharmacy Initiative Positively Impacts Patient Readmissions, Thaddeus T. Franz

Pharmacy Faculty Publications

No abstract provided.

Comparison Of Estrone And 17Β-Estradiol Levels In Commercial Goat And Cow Milk, D. W. Farlow, X. Xu, T. D. Veenstra

Pharmaceutical Sciences Faculty Publications

Increased levels of estrogen metabolites are believed to be associated with cancers of the reproductive system. One potential dietary source of these metabolites that is commonly consumed worldwide is milk. In North America, dairy cows are the most common source of milk; however, goats are the primary source of milk worldwide. In this study, the absolute concentrations of unconjugated and total (unconjugated plus conjugated) estrone (E(1)) and 17β-estradiol (E(2)) were compared in a variety of commercial cow milks (regular and organic) and goat milk. A lower combined concentration of E(1) and E(2) was found in goat milk than in any …

Job Placement Of Pgy1 Ambulatory Care Pharmacy Residents In Ohio, Sarah Anderson, Rachel R. Bull, Ruth Choi, Bethany Gustin, Joshua Knoebel, Courtney Noll, Jessica Taylor, Rebecca Widder, Kelly J. Hiteshew

Pharmacy Practice Faculty Presentations

No abstract provided.

Survey Of Community Pharmacy Customers' Medication Storage And Disposal Methods, Ryan Biddinger, Laura Farleman, Alex Jannsen, Mallory Martin, Anna M. Smith, Chelsea Wamsley, Tracy R. Frame

Pharmacy Practice Faculty Presentations

No abstract provided.

Nurse-Pharmacist Collaboration In The Delivery Of Continuous Renal Replacement Therapy, Jeb Ballentine

Jeb Ballentine, Pharm.D., R.Ph.

No abstract provided.

Nurse-Pharmacist Collaboration In The Delivery Of Continuous Renal Replacement Therapy, Jeb Ballentine

Pharmacy Faculty Presentations

No abstract provided.

Looking Back At Genomic Medicine In 2011, Charles Auffray, Timothy Caulfield, Muin J. Khoury, James R. Lupski, Matthias Schwab, Timothy Veenstra

Pharmaceutical Sciences Faculty Publications

No abstract provided.