Pharmacy and Pharmaceutical Sciences Commons^™

Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, Matthew D. Stryker, Michael Kane, Robert Busch

Excerpts in Pharmacy Research Journal

The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and gain-of-function mutations were first described in 2003. The gain-of-function mutations observed were associated with low-density lipoprotein-cholesterol (LDL-C) levels in the 400’s, in addition to premature cardiovascular disease. Subsequent loss-of-function experiments conducted in mice demonstrated marked reductions in plasma cholesterol levels in the absence of PCSK9. Physiologically, PCSK9 serves as a chaperone protein and functions to reduce low-density lipoprotein (LDL) receptor recycling; consequently, less LDL-C is removed from circulation and serum lipid concentrations become elevated. Inhibition of PCSK9 prevents LDL receptor degradation and preserves receptor recycling to the hepatocyte surface; this in …

Modeling With Medicinal Chemistry: Practical Innovative Technology-Based Activity To Enhance Student’S Learning Through Inter-Departmental Collaboration: Part I, Miriam Ansong, Denise Simpson, Nicole K. Stute

Excerpts in Pharmacy Research Journal

Background: Concepts of formulary management and its applications in clinical practice is a challenge faced by many first professional year pharmacy students. This challenge may be attributed to a lack of foundational knowledge and practical skills at this level. Preparing students for lifelong learning mandates early exposure to practical application of concepts. This warrants the need for students to integrate knowledge, skills, abilities, and attitudes in clinical practice. As a result, a state-of-the-art one stop shopping structure of the day (SOD) activity was created for P1 pharmacy students to enable the authors to assess their skill sets.

Objective: The objective …

Research And Publication Highlights, Miriam Ansong

Excerpts in Pharmacy Research Journal

Bibliography of completed research and book chapters

Protein Analysis Of Human Lacrimal Fluid In Varying Age Groups, Jayson M. Brewin, Daniel C. James, Neil Klinger, Jenna G. Lawhead, Nathaniel J. Luce, Amy Wuobio, Lindsay Florkey, Rocco J. Rotello

Excerpts in Pharmacy Research Journal

Purpose: The objective of this research project was to identify proteins secreted from human lacrimal fluids onto the extra-ocular surface of the eye that could be later used to predict eye health, disease, and age-related changes. The identification of specific lacrimal proteins in relative quantities and patterns in younger versus older patients may reflect both ocular and extra-ocular disease states.

Methods: This observational study collected samples of lacrimal fluid from 20 subjects between the ages of 18 and 25 years and 20 subjects over the age of 50 years with the use of Schirmer strips. The protein composition of these …

Welcome To The Excerpts In Pharmacy Research Journal, Miriam Ansong, Melissa J. Beck, Ginger Cameron, Rocco Rotello

Excerpts in Pharmacy Research Journal

The editorial board at Cedarville University School of Pharmacy welcomes you to the inaugural issue of the Excerpts in Pharmacy Research Journal (ISSN 2374-4693).