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Efficacy And Safety Of Checkpoint Inhibitors In Clear Cell Renal Cell Carcinoma: A Systematic Review Of Clinical Trials, Muhammad Ashar Ali
Efficacy And Safety Of Checkpoint Inhibitors In Clear Cell Renal Cell Carcinoma: A Systematic Review Of Clinical Trials, Muhammad Ashar Ali
Hematology/Oncology and Stem Cell Therapy
Renal cell carcinoma (RCC) is the most common kidney cancer in adults (approximately 90%), and clear cell RCC (ccRCC) is the most frequent histologic subtype (approximately 75%). We reviewed the safety and efficacy of checkpoint inhibitors (CPIs) in ccRCC, identifying 5927 articles in PubMed, Embase, Cochrane, and Web of Science. Ten randomized control (N ¼ 7765) and 10 non-randomized (N ¼ 572) studies were included. Overall, 4819 patients treated with CPI combinations were compared with everolimus, sunitinib, or placebo. Overall response rates (ORR) were 9e25% with nivolumab (niv), 42% with niv þ ipilimumab (ipi), 55.7% with niv þ cabozantinib, 56% …