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University of Tennessee Health Science Center
Anchorage Independent Survival; Anoikis; Beta-Catenin; Metastasis; MUC13; YAP1
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Muc13 Enhances Colorectal Cancer Metastasis, Kyle Doxtater
Muc13 Enhances Colorectal Cancer Metastasis, Kyle Doxtater
Theses and Dissertations (ETD)
Colorectal cancer (CRC) is one of the most prevalent cancer worldwide with a 5% lifetime incidence in developed countries. It is third most common cause of cancer related death in the United States and the second deadliest when men and women are combined. Encouragingly due to changes in dietary lifestyle, screening colonoscopy, and advancement in treatments the mortality has decreased in recent years. Most sporadic CRCs develop from polyploid adenomas and are preceded by intramucosal carcinomas (stage 0), which can progress into more malignant forms. This developmental process is known as the adenoma-carcinoma sequence. Early detection and endoscopic removal are …