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Full-Text Articles in Other Medicine and Health Sciences
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Hormesis And Ginseng: Ginseng Mixtures And Individual Constituents Commonly Display Hormesis Dose Responses, Especially For Neuroprotective Effects, Edward Calabrese Ph.D.
Environmental Health Sciences Faculty Publication Series
This paper demonstrates that ginseng mixtures and individual ginseng chemical constituents commonly induce hormetic dose responses in numerous biological models for endpoints of biomedical and clinical relevance, typically providing a mechanistic framework. The principal focus of ginseng hormesis-related research has been directed toward enhancing neuroprotection against conditions such as Alzheimer’s and Parkinson’s Diseases, stroke damage, as well as enhancing spinal cord and peripheral neuronal damage repair and reducing pain. Ginseng was also shown to reduce symptoms of diabetes, prevent cardiovascular system damage, protect the kidney from toxicities due to immune suppressant drugs, and prevent corneal damage, amongst other examples. These …
Hormesis: Path And Progression To Significance, Edward J. Calabrese
Hormesis: Path And Progression To Significance, Edward J. Calabrese
Environmental Health Sciences Faculty Publication Series
This paper tells the story of how hormesis became recognized as a fundamental concept in biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas related to enhancing biological performance. This paper assesses how hormesis enhances resilience to normal aging and protects against a broad spectrum of neurodegenerative, cardiovascular, and other diseases, as well as trauma and other threats to health and well-being. This paper also explains the application of hormesis to several neurodegenerative diseases such as Parkinson’s and Huntington’s disease, macrophage polarization and its systematic adaptive protections, and the role of hormesis in enhancing stem cell functioning and …
The Emergence Of The Dose–Response Concept In Biology And Medicine, Edward J. Calabrese
The Emergence Of The Dose–Response Concept In Biology And Medicine, Edward J. Calabrese
Environmental Health Sciences Faculty Publication Series
A historical assessment of the origin of the dose–response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose–response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.