Other Medicine and Health Sciences Commons^™

Defining Patient-Oriented Research For The Average Person (And Potential Research Partner), Dennis J. Baumgardner

Dennis J. Baumgardner, MD

In this introduction to the first issue of 2019, the editor-in-chief of Journal of Patient-Centered Research and Reviews offers additional context to the findings of Kaur and Pluye (p. 7), who methodically formalized an operational definition of patient-oriented research for the purposes of searching bibliographic databases. A possible succinct, lay definition of patient-oriented research for the average “person on the street” is proposed.

Uncertainty And Competing Priorities In Shared Clinical Decision-Making, Dennis J. Baumgardner

Dennis J. Baumgardner, MD

In this issue introduction, the editor-in-chief of Journal of Patient-Centered Research and Reviews observes that a connecting thread among the articles published therein is an element of uncertainty among patients and clinicians. Competing priorities for the patient also may be present. Several approaches to overcoming these prevalent conflicts to delivery of better health care have been proposed, the most important of which may be clinicians embracing a will to practice shared decision-making.

A Rare Association Of Giant Cell Arteritis With Recurrent Corneal Ulcer, Sailaja Bondalapati, Kay Khine, Maya Bitar, David Chesnutt, Richard M. Davis

Maya S. Bitar

We report a rare case of association of temporal arteritis with recurrent central corneal ulcer. A 91-year-old male with a remote history of clinically diagnosed giant cell arteritis (GCA) and penetrating keratoplasty (PK) for corneal edema in 1990’s in the left eye presented with irritation and severe dry eye. He progressively developed central corneal ulcer regardless of treatment with aggressive lubrication and patching. The clinical course, blood tests and temporal artery biopsy results yielded the diagnosis of recurrent GCA. The clinical course improved after starting oral steroids. The case report illustrates the importance of ruling out GCA in patients with …

Developing Hyperpolarized Silicon Particles For In Vivo Mri Targeting Of Ovarian Cancer, Nicholas Whiting, Jingzhe Hu, Niki M. Zacharias, Ganesh L. R. Lokesh, David E. Volk, David G. Menter, Rajesha Rupaimoole, Rebecca Previs, Anil K. Sood, Pratip Bhattacharya

Nicholas Whiting

The Impact Of Alzheimer’S Disease In An Aging Rural Population, Lynne J. Goebel, Vivian M. Minkemeyer, Courtney Wellman

Lynne J. Goebel

West Virginia already has a large elderly population, and it is expected to increase along with the elderly population of the nation as a whole. Since the most important risk factor for Alzheimer’s disease is older age, it is not surprising that the prevalence of Alzheimer’s disease is projected to increase significantly over the next thirty-five years. This paper discusses the prevalence of Alzheimer’s disease in West Virginia, programs available to assist people and caregivers affected by the disease, and the associated economic burden of the disease.

Preventing And Treating Type 2 Diabetes Through A Physically Active Lifestyle, Raymond W. Leung, Jim Kamla, Man-Cheong Lee, Jennifer Y. Mak

Jennifer Y Mak

By the late 1960s, the increasing number of type 2 diabetic cases in children and adolescents rapidly presented a signifi cant public health issue recognized by the American Diabetes Association (2000). Since then, the prevalence of pediatric type 2 diabetes appears to be on the rise not only in the United States but all around the world (Gungor et al., 2005). In the United States, an increase from fewer than four percent to more than 50 percent of new cases of type 2 diabetes in the pediatric population was reported between the years of 1982 and 1998 (American Diabetes Association, …

Absolute And Relative Changes (Delta) In Troponin I For Early Diagnosis Of Myocardial Infarction: Results Of A Prospective Multicenter Trial., Alan B Storrow, Richard M Nowak, Deborah B Diercks, Adam J Singer, Alan H B Wu, Erik Kulstad, Frank Lovecchio, Christian Fromm, Gary Headden, Tracie Potis, Christopher J Hogan, Jon W Schrock, Daniel P Zelinski, Marna Greenberg, Robert H Christenson, James C Ritchie, Janna S Chamberlin, Kurtis R Bray, Daniel W Rhodes, Deirdre Trainor, Paula C Southwick

Marna R Greenberg DO, MPH, FACEP

OBJECTIVES: We investigated absolute and relative cardiac troponin I (TnI) delta changes, optimal sampling protocols, and decision thresholds for early diagnosis of myocardial infarction (MI). Serial cardiac biomarker values demonstrating a rise and/or fall define MI diagnosis; however the magnitude of change, timing, and diagnostic accuracy of absolute versus relative (percentage) deltas remains unsettled. METHODS: We prospectively measured TnI (AccuTnI+3™, Beckman Coulter) at serial time intervals in 1929 subjects with chest pain or equivalent symptoms of acute coronary syndrome at 14 medical centers. Diagnosis was adjudicated by an independent central committee. RESULTS: Elevated TnI above a threshold of 0.03ng/mL demonstrated …

Real-Time Mri-Guided Catheter Tracking Using Hyperpolarized Silicon Particles, Nicholas Whiting, Jingzhe Hu, Jay V. Shah, Maja C. Cassidy, Erik Cressman, Niki Zacharias Millward, David G. Menter, Charles M. Marcus, Pratip K. Bhattacharya

Nicholas Whiting

Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik

Lotti Tajouri

Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME. Methods: The participants in the study comprised 65 (47.2 ± 11.5 years) CFS/ME participants and 21 (45.2 ±9.3 years) non-fatigued controls. Flow cytometry protocols were used to assess NK subsets and NK cytotoxic activity at various time points that …

Welcome To The Journal Of Evolution And Health, Aaron Blaisdell, Paul Jaminet, David C. Pendergrass

Aaron P Blaisdell

Welcome to the first issue of the Journal of Evolution and Health! The Journal of Evolution and Health is the peer-reviewed, open-access journal of the Ancestral Health Society, a community of scientists, healthcare professionals, and laypersons who collaborate to understand health challenges from an evolutionary perspective.

Cytotoxic Lymphocyte Micrornas As Prospective Biomarkers For Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Kevin Ashton, Mieke Van Driel, Donald Staines, Daniel Peterson, Gunn Atkinson, Sonia Marshall-Gradisnika

Kevin Ashton

Background: Immune dysfunction associated with a disease often has a molecular basis. A novel group of molecules known as microRNAs (miRNAs) have been associated with suppression of translational processes involved in cellular development and proliferation, protein secretion, apoptosis, immune function and inflammatory processes. MicroRNAs may be implicated in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), where immune function is impaired. The objective of this study was to determine the association between miRNAs in cytotoxic cells and CFS/ME. Methods: Natural Killer (NK) and CD8+T cells were preferentially isolated from peripheral blood mononuclear cells from all participants (CFS/ME, n = 28; mean age = …

Voluntary Running In Mice Beneficially Modulates Myocardial Ischemic Tolerance, Signaling Kinases, And Gene Expression Patterns, Boris Budiono, Louise See Hoe, Jason Peart, Surendran Sabapathy, Kevin Ashton, Luke Haseler, John Headrick

Kevin Ashton

Exercise triggers hormesis, conditioning hearts against damaging consequences of subsequent ischemia-reperfusion (I/R). We test whether “low-stress” voluntary activity modifies I/R tolerance and molecular determinants of cardiac survival. Male C57BL/6 mice were provided 7-day access to locked (7SED) or rotating (7EX) running-wheels before analysis of cardiac prosurvival (Akt, ERK 1/2) and prodeath (GSK3β) kinases, transcriptomic adaptations, and functional tolerance of isolated hearts to 25-min ischemia/45-min reperfusion. Over 7 days, 7EX mice increased running from 2.1 ± 0.2 to 5.3 ± 0.3 km/day (mean speed 38 ± 2 m/min), with activity improving myocardial I/R tolerance: 7SED hearts recovered 43 ± 3% of …

Longitudinal Investigation Of Natural Killer Cells And Cytokines In Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Ekua Brenu, Mieke Van Driel, Donald Staines, Kevin Ashton, Sharni Hardcastle, James Keane, Lotti Tajouri, Daniel Peterson, Sandra Ramos, Sonya Marshall-Gradisnik

Kevin Ashton

Background: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an etiologically unexplained disorder characterised by irregularities in various aspects of the immunological function. Presently, it is unknown whether these immunological changes remain consistent over time. This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME. Methods: The participants in the study comprised 65 (47.2 ± 11.5 years) CFS/ME participants and 21 (45.2 ±9.3 years) non-fatigued controls. Flow cytometry protocols were used to assess NK subsets and NK cytotoxic activity at various time points that …

Reference Bias: Presentation Of Extreme Health States Prior To Eq-Vas Improves Health-Related Quality Of Life Scores. A Randomised Cross-Over Trial, Steven Mcphail, Elaine Beller, Terry Haines

Elaine Beller

Background - Clinical practice and clinical research has made a concerted effort to move beyond the use of clinical indicators alone and embrace patient focused care through the use of patient reported outcomes such as health-related quality of life. However, unless patients give consistent consideration to the health states that give meaning to measurement scales used to evaluate these constructs, longitudinal comparison of these measures may be invalid. This study aimed to investigate whether patients give consideration to a standard health state rating scale (EQ-VAS) and whether consideration of good and poor health state descriptors immediately changes their self-report.

Methods …

The Palmer Philosophy Of Chiropractic – An Historical Perspective., Dennis M. Richards

Dennis M Richards

This paper presents the Palmer philosophy of chiropractic from an historical viewpoint. It examines how influences in the life of DD Palmer, such as spiritualism, theosophy and magnetic healing helped to shape the chiropractic philosophy expressed by him. It also oulines the philosophy of BJ Palmer, explaining how it may have been influenced by legal challenges to the early pioneers of chiropractic. Contemporary expression of the Palmer philosophy, as articulated by Strang, is also noted.