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Immunologic Mechanisms Involved With Human Endodontic Lesions, Sunita V. Prabhu
Immunologic Mechanisms Involved With Human Endodontic Lesions, Sunita V. Prabhu
Loma Linda University Electronic Theses, Dissertations & Projects
Endodontic or root canal infection results in immunologic changes in periapical region, which causes the destruction of pulpal and periapical tissue. No definitive study has identified a specific organism or a group of organisms as a etiological agents. Past studies have indicated that immunoglobulin E play a significant role in the pathogenesis of periapical lesions. The presence of this factor suggests that some of the endodontic flare-ups may be IgE-mediated hypersensitivity reactions. Antibody levels of IgA have been quantitatively measured by ELISA and IgE by modified RAST assay, against eleven oral bacteria which are routinely isolated from such lesions. The …