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Full-Text Articles in Organisms
The Effect Of Alcaligenes Faecalis On Inhibition Of Candida Albicans Biofilm And Planktonic Growth, Nausheen A. Siddiqui
The Effect Of Alcaligenes Faecalis On Inhibition Of Candida Albicans Biofilm And Planktonic Growth, Nausheen A. Siddiqui
Undergraduate Honors Theses
Candida albicans is a fungal microorganism found on the human body and in the environment. An opportunistic pathogen causing local and systemic infection, this fungus is one of the leading causes of nosocomial infections. More alarming is its growing resistance against the limited number of antifungals we have for treatment Candida infections. An area of current research, termed polymicrobial interactions, focuses on how different microorganisms interact with each other for limited space, nutrients, and survival. The current study focuses on attempting to inhibit planktonic and biofilm growth stages by using the benign bacterium Alcaligenes faecalis, previously shown in our …
Novel Small Molecule Antifungals For Invasive Fungal Infections, Emily Dennis
Novel Small Molecule Antifungals For Invasive Fungal Infections, Emily Dennis
Theses and Dissertations--Pharmacy
Human fungal pathogens cause a range of diseases from benign skin conditions (i.e., ringworm) to thrush, mucosal membrane infections, and life-threatening systemic infections including bloodstream infections (i.e., aspergillosis and candidiasis) and Cryptococcal meningitis. These systemic infections occur most often in immunocompromised individuals and have high mortality rates. Current antifungal agents used in the clinic belong to three main classes: the polyenes (e.g., amphotericin B (AmB)), the echinocandins (e.g., caspofungin (CFG)), and the azoles (e.g., fluconazole (FLC)). In addition, the antimetabolite pyrimidine analogue flucytosine is used in combination with AmB. The …