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Concentration Of Leukotrienes B4 And C4 In Human Periradicular Lesions, Elisabetta Cotti
Concentration Of Leukotrienes B4 And C4 In Human Periradicular Lesions, Elisabetta Cotti
Loma Linda University Electronic Theses, Dissertations & Projects
The 5-lipoxygenase metabolites of arachidonic acid such as leukotrienes (LT) B4 and C4, are potent mediators of inflammation. The purpose of this investigation was to determine the concentrations of LTB4 and LTC4 in human periradicular lesions. Specimens from asymptomatic and symptomatic patients were obtained and immediately frozen in liquid nitrogen. Periradicular tissues from unerupted third molars as well as chronically inflamed gingival tissues were also obtained, frozen and were used as negative and positive controls respectively. The concentrations of LTB4 and LTC4 were determined by the reverse phase high pressure liquid chromatography. Representative …