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Investigating The Regulation Of A Fatty Acid Efflux Pump In Methicillin Resistant Staphylococcus Aureus, James Et Schneider
Investigating The Regulation Of A Fatty Acid Efflux Pump In Methicillin Resistant Staphylococcus Aureus, James Et Schneider
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Community acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strain USA300 has rapidly achieved pandemic status in the community setting. To persist on human hosts, USA300 requires mechanisms to overcome innate immune defenses of the skin, which include antimicrobial unsaturated free fatty acids (uFFAs). This study evaluated efflux mediated mechanisms of resistance to uFFA. tet38 encoding an efflux pump that was previously implicated in resistance to palmitoleic acid, was found to have no role in resistance to uFFA. Conversely, the farE encoded efflux pump conferred resistance to linoleic and arachidonic acid, but not palmitoleic acid. farE expression was induced by uFFA, but …