Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Animals (1)
- Antigen Presentation (1)
- Bacteria (1)
- Beta-Glucans (1)
- CD4-Positive T-Lymphocytes (1)
-
- Cytokines (1)
- Dendritic Cells (1)
- Dendritic cells (1)
- Extracellular (1)
- Foodborne infection (1)
- Fungal infection (1)
- Gene Expression Regulation (1)
- Histocompatibility Antigens Class II (1)
- Listeria monocytogenes (1)
- Lung defense (1)
- Lymphocyte Activation (1)
- Mesenteric lymph nodes (1)
- Mice (1)
- Monocytes (1)
- Pathogen-Associated Molecular Pattern Molecules (1)
- Pneumocystis (1)
- Pneumonia, Pneumocystis (1)
- T cells (1)
- Transcription Factors (1)
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Organisms
The Trophic Life Cycle Stage Of The Opportunistic Fungal Pathogen Pneumocystis Murina Hinders The Ability Of Dendritic Cells To Stimulate Cd4+ T Cell Responses, Heather M. Evans, Andrew Simpson, Shu Shen, Arnold J. Stromberg, Carol L. Pickett, Beth A. Garvy
The Trophic Life Cycle Stage Of The Opportunistic Fungal Pathogen Pneumocystis Murina Hinders The Ability Of Dendritic Cells To Stimulate Cd4+ T Cell Responses, Heather M. Evans, Andrew Simpson, Shu Shen, Arnold J. Stromberg, Carol L. Pickett, Beth A. Garvy
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The life cycle of the opportunistic fungal pathogen Pneumocystis murina consists of a trophic stage and an ascus-like cystic stage. Infection with the cyst stage induces proinflammatory immune responses, while trophic forms suppress the cytokine response to multiple pathogen-associated molecular patterns (PAMPs), including β-glucan. A targeted gene expression assay was used to evaluate the dendritic cell response following stimulation with trophic forms alone, with a normal mixture of trophic forms and cysts, or with β-glucan. We demonstrate that stimulation with trophic forms downregulated the expression of multiple genes normally associated with the response to infection, including genes encoding …
Role Of Intracellular Growth During The Gastrointestinal Stage Of Listeria Monocytogenes Infection, Grant Steven Jones
Role Of Intracellular Growth During The Gastrointestinal Stage Of Listeria Monocytogenes Infection, Grant Steven Jones
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Listeria monocytogenes is a facultative intracellular bacterium that causes foodborne disease in humans. L. monocytogenes invade the gut mucosa and then disseminate, causing systemic infections associated with high mortality rates in immunocompromised individuals. It is unknown how L. monocytogenes traffic to the mesenteric lymph nodes, which represent an important bottleneck for systemic spread. In addition, little is known about the gastrointestinal stage of infection due to the general resistance of mice to oral infection with L. monocytogenes. Our laboratory developed a novel foodborne mouse model of listeriosis utilizing a murinized strain of L. monocytogenes to investigate the gastrointestinal stage …