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Full-Text Articles in Organisms
Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration., Michael M. Moran, Madhuri Kango-Singh, Amit Singh
Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration., Michael M. Moran, Madhuri Kango-Singh, Amit Singh
Amit Singh
Background: Alzheimer's disease (AD) is a debilitating age related progressive neurodegenerative disorder characterized by the loss of cognition, and eventual death of the affected individual. One of the major causes of AD is the accumulation of Amyloid-beta 42 (Aβ42) polypeptides formed by the improper cleavage of amyloid precursor protein (APP) in the brain. These plaques disrupt normal cellular processes through oxidative stress and aberrant signaling resulting in the loss of synaptic activity and death of the neurons. However, the detailed genetic mechanism(s) responsible for this neurodegeneration still remain elusive. Methodology/ Principle Findings: We have generated a transgenic Drosophila eye model …
Adverse Health Consequences Following Aerial Spraying With Bacillus Thuringiensis (Var. Kursraki) (Btk) To Control The Gypsy Moth: Flaws In Government Risk Assessments And In Public Health Officials' Attitudes, Richard B. Philp
Richard B. Philp
The soil bacterium Bacillus thuringiensis is noteworthy for its ability to infect fatally the digestive tract of moths, butterflies and other insects, making it an attractive biological agent to control insects that can damage crops and trees. One subspecies B. thuringiensis (var. kurstaki) is used in commercial preparations such as Foray 48B that can be applied as a spray on the ground or from aircraft. The latter approach is especially appealing as large areas can be sprayed at relatively low cost. The use of such spraying in populated, urban areas often results in reports of illnesses such as nausea, vomiting, …