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Full-Text Articles in Organisms
Can Large Dsdna-Containing Viruses Provide Information About The Minimal Genome Size Required To Support Life?, James L. Van Etten
Can Large Dsdna-Containing Viruses Provide Information About The Minimal Genome Size Required To Support Life?, James L. Van Etten
James Van Etten Publications
The genomes of a few viruses, such as Bacillus megaterium phage G (670 kb) and the chlorella viruses (330 to 380 kb), are larger than the predicted minimal genome size required to support life (ca. 320 kb). A comparison of the 256 proteins predicted to be required for life with the putative 376 proteins encoded by chlorella virus PBCV-1, as well as those encoded by other large viruses, indicates that viruses lack many of these “essential” genes. Consequently, it is unlikely that viruses will aid in determining the minimal number and types of genes required for life. However, viruses may …
An Endophytic Fungus As A Source Of New Antifungal Compounds, Lisa Marie Jungbauer
An Endophytic Fungus As A Source Of New Antifungal Compounds, Lisa Marie Jungbauer
Honors Theses, 1963-2015
Medical advances in society such as organ transplants, prolonged chemotherapy, and those that lengthen the lives of AIDS patients and the elderly increase the number of immunocompromised individuals(1). When the immune system is compromised, opportunistic fungi can flourish and become fatal. Current antifungal treatments are limited and often toxic(2,3). In addition, strains of fungi resistant to available antifungals are emerging(4,5). Fungi were selected as the source of potential new antifungal agents because fungal antagonism has been reported in most fungal ecosystems(6). Endophytic fungi, which inhabit the spaces between plant cells, are known producers of natural products and that assist plants …