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Development Of Periapical Lesions In Immunosuppressed Rats, Phillip A. Waterman Jr.
Development Of Periapical Lesions In Immunosuppressed Rats, Phillip A. Waterman Jr.
Loma Linda University Electronic Theses, Dissertations & Projects
The pathogenesis of periapical lesions is the interaction of the oral flora with the existing host defenses. The role of bacteria has been established in endodontic disease but the contribution of the host defenses in periapical lesion formation is less clear. The purpose of this study was to compare periapical lesion development in immunosuppressed rats with that in normal rats. Thirty-five, eight-week old Sprague-Dawley rats were equally divided into seven groups. Groups 1, 2, and 3 were given weekly injections of Cytoxan, an immunosuppressive agent. Groups 4, 5, and 6 received no immunosuppressive therapy. Group 7 served as a control, …