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Novel Mammalian Models For Understanding And Treating Spinal Cord Injury, Michael B. Orr
Novel Mammalian Models For Understanding And Treating Spinal Cord Injury, Michael B. Orr
Theses and Dissertations--Physiology
Spinal cord injury (SCI) is devastating and often leaves the injured individual with persistent dysfunction. The injury persists because humans have poor wound repair and there are no pharmacologic treatments to induce wound repair after SCI. The continued efforts to discover therapeutic targets and develop treatments heavily relies on animal models. The purpose of this project is to develop and study novel mammalian models of SCI to provide insights for the development and effective implementation of SCI therapies.
Lab mice (Mus musculus) are a powerful tool for recapitulating the progression and persistent damage evident in human SCI, but …