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Full-Text Articles in Organisms
Global Evolutionary Dynamics And Resistome Analysis Of Clostridioides Difficile Ribotype 017, Korakrit Imwattana, Papanin Putsathit, Deirdre A. Collins, Teera Leepattarakit, Pattarachai Kiratisin, Thomas V. Riley, Daniel R. Knight
Global Evolutionary Dynamics And Resistome Analysis Of Clostridioides Difficile Ribotype 017, Korakrit Imwattana, Papanin Putsathit, Deirdre A. Collins, Teera Leepattarakit, Pattarachai Kiratisin, Thomas V. Riley, Daniel R. Knight
Research outputs 2022 to 2026
Clostridioides difficile PCR ribotype (RT) 017 ranks among the most successful strains of C. difficile in the world. In the past three decades, it has caused outbreaks on four continents, more than other ‘epidemic’ strains, but our understanding of the genomic epidemiology underpinning the spread of C. difficile RT 017 is limited. Here, we performed high-resolution phylogenomic and Bayesian evolutionary analyses on an updated and more representative dataset of 282 non-clonal C. difficile RT 017 isolates collected worldwide between 1981 and 2019. These analyses place an estimated time of global dissemination between 1953 and 1983 and identified the acquisition of …