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Thermo-Responsive Antibiotic-Eluting Coatings For Treating Infection Near Orthopedic Implants, Jan Chung Kwan
Thermo-Responsive Antibiotic-Eluting Coatings For Treating Infection Near Orthopedic Implants, Jan Chung Kwan
Electronic Thesis and Dissertation Repository
The clinical effectiveness of orthopedic devices to restore the function of joints has been well established yet there is a lack of development in associated infections. As the demand for orthopedic surgeries continues to rise, infection remains a growing problem and one of the main reasons for revision surgeries. Bacterial contamination of the surgical site followed by adhesion of bacteria onto the surface of orthopedic devices leads to the formation of a biofilm which is a common initiator for infection. As a result, infection in the orthopedic field is commonly defined as orthopedic device-related infections (ODRI). There are limited options …
The Role Of Coagulase-Negative Staphylococcal Secreted Products On Staphylococcus Aureus And Staphylococcus Lugdunensis Infections, Denny Chin
Electronic Thesis and Dissertation Repository
The Staphylococcus genus is comprised of over 40 bacterial species. The most well-studied species in this genus is the notorious human pathogen Staphylococcus aureus, a bacterium that produces coagulase among many other virulence factors. Since S. aureus is a major health burden and causes a plethora of diseases in humans, it has received significant attention and much research has been done to understand its biology to treat diseases caused by this pathogen. However, the coagulase-negative staphylococci (CoNS) make up most of the staphylococcal species and have received less attention since they are thought to have a lesser impact on …