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Full-Text Articles in Organisms
Assessment Of Daf-19 Related Behavioral Defects, Loraina A. Stinson
Assessment Of Daf-19 Related Behavioral Defects, Loraina A. Stinson
Lawrence University Honors Projects
The daf-19 gene encodes the only RFX transcription factors in C. elegans, producing at least four related protein isoforms, one of which, DAF-19C, is responsible for ciliogenesis. Previous work by Senti and Swoboda (2008) demonstrated that adult worms deficient in all four DAF-19 proteins have extremely aberrant dwelling and roaming behavior on bacterial food. Most intriguingly, the addition of cDNA encoding the DAF-19C isoform restores cilia formation, but does not fully restore wild-type dwelling and roaming behavior. We are suggesting that additional neuron functions are needed to properly execute behaviors and these neuron functions require the activity of other …
Neurotoxicity Of Two Related Organophosphates On Caenorhabditis Elegans, Collin M. Brown
Neurotoxicity Of Two Related Organophosphates On Caenorhabditis Elegans, Collin M. Brown
Honors Program Projects
Organophosphates are a class of toxicants that act by inhibiting the activity of acetylcholinesterase, an enzyme vital to normal neuronal activity. Dimethoate and omethoate are two organophosphates that are chemical "cousins" of one another. Omethoate is a metabolite, or byproduct of dimethoate decomposition, and is more toxicologically active than dimethoate. Both toxicants were applied to cultures of Caenorhabditis elegans to determine two qualities of the organophosphates: their relative toxicity and their cumulative effects. The toxicity of omethoate was found to be significantly higher than that of dimethoate. Omethoate was found to have a 144.4% more lethal toxicity than dimethoate, and …