Organisms Commons^™

The Impact Of A 20% Vs. A 40% Caloric Restrictive Diet On Bone Mineral Density During The Growth Period In Male Rats, Kassandra Lee

Student Scholar Symposium Abstracts and Posters

Purpose: The purpose of this study was to determine the impact of a 20% and a 40% caloric restrictive diet on bone mineral density (BMD) and bone strength in male rats during the growth period. Methods: 32 male rats were randomly divided into: control groups (C20, n=8 and C40, n=8), a group fed the 20% caloric restrictive diet (D20, n=8), and a group fed the 40% caloric restrictive diet (D40, n=8). An animal in the caloric restrictive diet group was matched and pair fed with an animal in the control group for 6 weeks. Each caloric restrictive diet contained additional …

Hepatic Disposition Of Cyclosporine A In Isolated Perfused Rat Livers, Reza Mehvar, Anjaneya Chimalakonda

Pharmacy Faculty Articles and Research

PURPOSE. To develop an isolated perfused rat liver model to study the hepatic disposition of cyclosporine A (CyA) in both sexes.

METHODS. Livers were isolated from male (n = 6) and female (n = 7) rats and perfused with a physiological buffer in a single-pass manner. A bolus 1-mg dose of CyA was injected into the inlet catheter and periodical samples (0-15 min) were collected from the outlet perfusate. The concentrations of CyA in the outlet perfusate, collected bile (0-15 min), and liver tissue (at the end of perfusion) were quantitated by HPLC and subjected to statistical moment analysis. …