Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Nanomedicine (13)
- Life Sciences (5)
- Physical Sciences and Mathematics (5)
- Chemistry (3)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (2)
-
- Biochemistry (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Chemicals and Drugs (2)
- Other Medicine and Health Sciences (2)
- Bioethics and Medical Ethics (1)
- Biological Factors (1)
- Biology and Biomimetic Materials (1)
- Clinical Epidemiology (1)
- Diseases (1)
- Earth Sciences (1)
- Engineering (1)
- Environmental Health (1)
- Food Science (1)
- Law (1)
- Materials Science and Engineering (1)
- Medical Microbiology (1)
- Medical Sciences (1)
- Microbiology (1)
- Nucleic Acids, Nucleotides, and Nucleosides (1)
- Other Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physical Chemistry (1)
- Keyword
-
- Cytotoxicity (4)
- Cancer (2)
- Gastric cancer (2)
- Genotoxicity (2)
- Gold nanoparticle; fungi; nanoparticle shape; nanoparticle size; nanotoxicology (2)
-
- Gold nanoparticles (2)
- Graphene (2)
- Nanomaterials (2)
- Nanoparticles (2)
- Nanotoxicology (2)
- Protein corona (2)
- Theranostics (2)
- 49 Growth Process (1)
- Ablation (1)
- Accumulation in rat fetus (1)
- Amniotic membrane (1)
- Anti-bacterial mechanisms of NPs (1)
- Antibody conjugates; biosensing; bioreporter; lateral flow devices; nanoparticles aggregation; pH (1)
- Apoptotic (1)
- Arsenic contamination (1)
- Atmospheric cold plasma (1)
- Background correction (1)
- Bacteria (1)
- Biocompatibility (1)
- Biomedical applications (1)
- Cancer; Nanotechnology (1)
- Casein (1)
- Caspase-3 Apoptosis (1)
- Cellular internalisation (1)
- Colloidal stability (1)
Articles 31 - 31 of 31
Full-Text Articles in Nanotechnology
Impaired Clearance And Enhanced Pulmonary Inflammatory/Fibrotic Response To Carbon Nanotubes In Myeloperoxidase-Deficient Mice, Aidan Meade, Anna Shvedova, Alexandr Kapralov, Wei Hong Feng, Elena Kisin, Ashley Murray, Robert Mercer, Claudette St. Croix, Megan Lang, Simon Watkins, Nagarjun Konduru, Brett Allen, Jennifer Conroy, Gregg Kotchey, Bashir Mohamed, Yuri Volkov, Alexander Star, Bengt Fadeel, Valerian Kagan
Impaired Clearance And Enhanced Pulmonary Inflammatory/Fibrotic Response To Carbon Nanotubes In Myeloperoxidase-Deficient Mice, Aidan Meade, Anna Shvedova, Alexandr Kapralov, Wei Hong Feng, Elena Kisin, Ashley Murray, Robert Mercer, Claudette St. Croix, Megan Lang, Simon Watkins, Nagarjun Konduru, Brett Allen, Jennifer Conroy, Gregg Kotchey, Bashir Mohamed, Yuri Volkov, Alexander Star, Bengt Fadeel, Valerian Kagan
Articles
Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and proinflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO – one of the key-orchestrators of inflammatory response – in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of …