Psychiatric and Mental Health Commons^™

Positive Allosteric Modulator Of Gabab Receptor Alters Behavioral Effects But Not Afterdischarge Progression Induced By Partial Hippocampal Kindling., L Stan Leung, Miao Jin, Liangwei Chu, Jingyi Ma

Physiology and Pharmacology Publications

Hippocampal seizures decreased the function of GABAB receptors, which may further increase seizure susceptibility and contribute to development of schizophrenia-like behaviors. Recent literature indicates that GABAB receptor agonist may normalize schizophrenia-like behaviors and prevent drug-induced behavioral sensitization. We hypothesized that positive modulation of GABAB receptor function during seizure induction will reduce seizure-induced schizophrenia-like behaviors. Using a partial hippocampal kindling model, afterdischarges were induced after injection of saline or dimethyl sulfoxide (vehicle-kindled rats), or a GABAB receptor positive allosteric modulator CGP7930, at 1 mg/kg i.p. (CGP1-kindled) or 5 mg/kg i.p. (CGP5-kindled). The increase in the primary afterdischarge duration during kindling was …

Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad

Electronic Thesis and Dissertation Repository

PDZ (PSD95/Disc Large/Zona Occludens) domain-containing proteins are scaffolding proteins that play important roles in regulating the activity of G protein-coupled receptors. Corticotropin Releasing Factor Receptor 1 (CRFR1) and Serotonin 2A Receptor (5-HT_2AR) are two GPCRs that are commonly associated with mental disorders. Both receptors also contain a class I PDZ-binding motif at the carboxyl terminal tail. In the first chapter, we investigate the effects of CAL (CFTR-associated ligand) on regulating the trafficking and signaling of CRFR1. We demonstrate a role for CAL in inhibiting CRFR1 endocytosis, cell surface expression, and CRF-mediated ERK1/2 signaling via the CRFR1 PDZ-binding motif. …

Organisational Improvement Plan: System Of Care, Derek Haime

Electronic Thesis and Dissertation Repository

This organizational improvement plan (OIP) describes a way to develop and implement a system of care philosophy within a district school board with the intent of spreading this philosophy throughout the district, province, and country in the future. It is intended to be used as a tool to guide other district school boards interested in implementing a system of care. More specifically, the problem of practice this OIP is intended to address is as follows: “The current model of care for JK-8 students with mental health needs must improve. The service delivery system and pathways to treatment for child and …

Organisational Improvement Plan: System Of Care, Derek Haime

The Dissertation in Practice at Western University

This organizational improvement plan (OIP) describes a way to develop and implement a system of care philosophy within a district school board with the intent of spreading this philosophy throughout the district, province, and country in the future. It is intended to be used as a tool to guide other district school boards interested in implementing a system of care. More specifically, the problem of practice this OIP is intended to address is as follows: “The current model of care for JK-8 students with mental health needs must improve. The service delivery system and pathways to treatment for child and …

Exploring The Mobile Phone Digital Divide Among Individuals Experiencing Mental Illness: A Secondary Analysis, Jefferey R. Reed

Electronic Thesis and Dissertation Repository

ABSTRACT

Aim: To test van Dijk’s (2005) Framework for Understanding the Digital Divide. This framework examines social inequalities that influence the phenomenon of the digital divide and the implications it has upon social participation for individuals with mental illness.

Background: Mental illness is the second leading cause of disability and premature death, and constitutes more than 15% of the burden of disease in Canada (Centre for Addiction and Mental Health, 2012). Mobile phones may be useful in promoting health and social wellness among this population. It is unclear whether these individuals face disparities in the access to and use of …

Access To Care And The Impact Of Inequality Among Individuals With A History Of Mental Illness, Heather Atyeo

Electronic Thesis and Dissertation Repository

Using an Intersectionality framework, a secondary analysis of pre-existing data from the CURA2 Poverty and Social Inclusion study (Forchuk et al., 2010-2015) was used to explore the relationship between experiences of oppression and self-rated health among a cross-section of 293 community dwelling participants with a mental illness. Binary logistic regression was used to estimate the association between self-rated health and social identity (gender, ethnicity, education, homelessness, employment, disability); health care access was tested for both mediating and moderating effects. The final model explained between 18.9-25.2% of the variance in self-rated health; four independent variables made unique statistically significant contributions to …