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Articles 1 - 4 of 4
Full-Text Articles in Psychiatric and Mental Health
Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad
Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad
Electronic Thesis and Dissertation Repository
PDZ (PSD95/Disc Large/Zona Occludens) domain-containing proteins are scaffolding proteins that play important roles in regulating the activity of G protein-coupled receptors. Corticotropin Releasing Factor Receptor 1 (CRFR1) and Serotonin 2A Receptor (5-HT2AR) are two GPCRs that are commonly associated with mental disorders. Both receptors also contain a class I PDZ-binding motif at the carboxyl terminal tail. In the first chapter, we investigate the effects of CAL (CFTR-associated ligand) on regulating the trafficking and signaling of CRFR1. We demonstrate a role for CAL in inhibiting CRFR1 endocytosis, cell surface expression, and CRF-mediated ERK1/2 signaling via the CRFR1 PDZ-binding motif. …
Organisational Improvement Plan: System Of Care, Derek Haime
Organisational Improvement Plan: System Of Care, Derek Haime
Electronic Thesis and Dissertation Repository
This organizational improvement plan (OIP) describes a way to develop and implement a system of care philosophy within a district school board with the intent of spreading this philosophy throughout the district, province, and country in the future. It is intended to be used as a tool to guide other district school boards interested in implementing a system of care. More specifically, the problem of practice this OIP is intended to address is as follows: “The current model of care for JK-8 students with mental health needs must improve. The service delivery system and pathways to treatment for child and …
Exploring The Mobile Phone Digital Divide Among Individuals Experiencing Mental Illness: A Secondary Analysis, Jefferey R. Reed
Exploring The Mobile Phone Digital Divide Among Individuals Experiencing Mental Illness: A Secondary Analysis, Jefferey R. Reed
Electronic Thesis and Dissertation Repository
ABSTRACT
Aim: To test van Dijk’s (2005) Framework for Understanding the Digital Divide. This framework examines social inequalities that influence the phenomenon of the digital divide and the implications it has upon social participation for individuals with mental illness.
Background: Mental illness is the second leading cause of disability and premature death, and constitutes more than 15% of the burden of disease in Canada (Centre for Addiction and Mental Health, 2012). Mobile phones may be useful in promoting health and social wellness among this population. It is unclear whether these individuals face disparities in the access to and use of …
Access To Care And The Impact Of Inequality Among Individuals With A History Of Mental Illness, Heather Atyeo
Access To Care And The Impact Of Inequality Among Individuals With A History Of Mental Illness, Heather Atyeo
Electronic Thesis and Dissertation Repository
Using an Intersectionality framework, a secondary analysis of pre-existing data from the CURA2 Poverty and Social Inclusion study (Forchuk et al., 2010-2015) was used to explore the relationship between experiences of oppression and self-rated health among a cross-section of 293 community dwelling participants with a mental illness. Binary logistic regression was used to estimate the association between self-rated health and social identity (gender, ethnicity, education, homelessness, employment, disability); health care access was tested for both mediating and moderating effects. The final model explained between 18.9-25.2% of the variance in self-rated health; four independent variables made unique statistically significant contributions to …