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2018

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Articles 541 - 570 of 662

Full-Text Articles in Mental and Social Health

Healthcare Providers’ Perceptions Of Pregnant Women, Allison Goderwis Jan 2018

Healthcare Providers’ Perceptions Of Pregnant Women, Allison Goderwis

Theses and Dissertations--Family Sciences

Health care providers’ (N = 421) implicit perceptions of pregnant women based on age, race or ethnicity, marital status, and socioeconomic status are assessed through a true-experiment design. Ordinal and binary regression analyses revealed that respondents felt more pity for an unmarried than married pregnant woman and more anger toward an unemployed pregnant woman without health insurance compared to a pregnant woman who was employed with health insurance. Male, Asian, and Hispanic respondents were less likely to help the pregnant woman, Black and protestant respondents were more likely to express some degree of anger toward the pregnant woman, and …


Development And Validation Of The College Mental Health Perceived Competency Scale, Michael T. Kalkbrenner, Christopher A. Sink Jan 2018

Development And Validation Of The College Mental Health Perceived Competency Scale, Michael T. Kalkbrenner, Christopher A. Sink

Counseling & Human Services Faculty Publications

College counselors provide training to their campus constituents on various mental health issues, including the identification of warning signs and the referral of students to appropriate resources. Though extensive information on these topics is available in the counseling literature, college counselors lack a psychometrically sound screening instrument to support some of these educational efforts. To meet this need, the present researchers developed and validated the College Mental Health Perceived Competency Scale (CMHPCS). Based largely on self-determination theory, the measure appraises college student and faculty members’ perceived competence for supporting student mental health. Reliability and construct validity of the CMHPCS are …


Evaluation Of A Peer Mentor Program On Adult Heroin Overdose Patients In The Emergency Department, Christina Schipper Jan 2018

Evaluation Of A Peer Mentor Program On Adult Heroin Overdose Patients In The Emergency Department, Christina Schipper

DNP Projects

Abstract

PURPOSE: According to the Centers for Disease Control and Prevention (CDC), the rate of heroin use and heroin overdoses has greatly increased in the last decade, regardless of sex, age, race or income. The emergency department (ED) is a common place heroin users present, often as an overdose or due to a complication from their drug use. To address the current opioid epidemic, the CDC calls for increased access to substance abuse treatment services. Peer Mentors placed in the ED serve as a link for the patient to recovery services. The purpose of this study is to evaluate the …


Education And Prevention Of Stress And Ptsd In Prehospital Care Providers, Adriana Goad Jan 2018

Education And Prevention Of Stress And Ptsd In Prehospital Care Providers, Adriana Goad

A with Honors Projects

The field of prehospital emergency care is one full of unpredictability, high physical demand, and mental stress. EMTs and Paramedics are called to the unknown to treat whatever they come upon with the limited supplies and equipment that can be found in their trauma bag and ambulances. Some calls may be rewarding as they save the life of a patient, or they can be run of the mill as they get a call for a person not feeling well. Some calls, though, do not end in a relaxed drop off at the ED and back to the station for the …


Efforts To Reduce Concomitant Opioid And Benzodiazepine Prescribing At The Lexington Veterans Affairs Medical Center, Kaitlyn A. Staton Jan 2018

Efforts To Reduce Concomitant Opioid And Benzodiazepine Prescribing At The Lexington Veterans Affairs Medical Center, Kaitlyn A. Staton

MPA/MPP/MPFM Capstone Projects

The United States is in the throes of an opioid epidemic. Any person who uses an opioid medication may experience an intentional or unintentional overdose. An overdose is more likely to occur when an individual ingests an opioid in combination with certain classes of medications, such as benzodiazepines or nonbenzodiazepines (Z-drugs). These medications are more likely to cause sedation and respiratory depression when taken together. Veterans, due to their unique mental and physical health challenges, are more likely to experience an overdose when they receive a combination of opioid therapy with benzodiazepine or Z-drug therapy as opposed to a single …


Cocaine Choice: A Novel Procedure For Investigating Neuronal Activation Mediating Cocaine Preference, Jonathan Jenn-Sheng Chow Jan 2018

Cocaine Choice: A Novel Procedure For Investigating Neuronal Activation Mediating Cocaine Preference, Jonathan Jenn-Sheng Chow

Theses and Dissertations--Psychology

Cocaine use disorder is a significant health problem, negatively impacting individuals afflicted. While preclinical self-administration research has provided invaluable insight into the neurobehavioral mechanisms that underlie cocaine abuse, cocaine use outside of the laboratory occurs within an environment where other goods are also available ubiquitously. Although there is an ever-increasing literature investigating drug vs. non-drug choice in rodent models and how alternative goods can compete with the subjective value of cocaine, the neurobiological mechanisms that are associated with cocaine preference remains largely unknown. Additionally, current drug vs. non-drug choice studies use procedures that confound preference with intake, such that preference …


Comparing Daily Drivers Of Problem Drinking Among Older And Younger Adults: An Electronic Daily Diary Study Using Smartphones, Alexis Kuerbis, Hayley Treloar Padovano, Sijing Shao, Jessica Houser, Frederick Muench, Jon Morgenstern Jan 2018

Comparing Daily Drivers Of Problem Drinking Among Older And Younger Adults: An Electronic Daily Diary Study Using Smartphones, Alexis Kuerbis, Hayley Treloar Padovano, Sijing Shao, Jessica Houser, Frederick Muench, Jon Morgenstern

Publications and Research

Background—By 2030, numbers and proportions of older adults with substance-use problems are expected to increase. While risk factors for problem drinking in late life have been identified, it remains unknown whether these factors drive daily drinking among older problem drinkers. This study examined the daily drivers of drinking among problem drinkers, moderated by age, utilizing ecological momentary assessment (EMA). Method—Participants (N=139), ages 20–73, received daily EMA online surveys completed via a smartphone prior to initiation of treatment. Multilevel modeling tested the moderating impact of age on within- and between-person relationships between drinking and focal predictors (mood, loneliness, boredom, stress, poor …


Criminological Self-Efficacy: Increased Or Hindered From Crime Tv Shows, Dorothy Moore Jan 2018

Criminological Self-Efficacy: Increased Or Hindered From Crime Tv Shows, Dorothy Moore

All Master's Theses

There is an age-old question that surrounds whether or not media have an effect on its viewers. There is substantial evidence that supports the claim that violent content in media may increase relational, physical, and/or overall aggression levels. The aim of the current study is to explore the relationship between several factors that may be related to one’s belief in one’s ability (self-efficacy) to commit and get away with murder. These factors are the amount of crime TV a person watches, aggressive tendency, recklessness tendency, and potential protective factors. It is hypothesized that the more crime TV watched, the higher …


Trauma, Depression, And Burnout In The Human Rights Field: Identifying Barriers And Pathways To Resilient Advocacy, Sarah Knuckey, Margaret Satterthwaite, Adam Brown Jan 2018

Trauma, Depression, And Burnout In The Human Rights Field: Identifying Barriers And Pathways To Resilient Advocacy, Sarah Knuckey, Margaret Satterthwaite, Adam Brown

Faculty Scholarship

Human rights advocates often confront trauma and stress in their work. They are exposed to testimony about heinous abuses; work in insecure locations; visit physical sites of abuse; review forensic, photographic, and video evidence; directly witness abuses; experience threats; and can also suffer detention, be attacked, or be tortured themselves. Such exposure risks adversely impacting the wellbeing and mental health of advocates. While the human rights field is diverse and work varies widely, most – if not all – advocates are likely directly or indirectly exposed to potentially traumatic events or material in the course of their work. The degree …


Childhood Trauma: An Analysis Of Associated Co-Morbidities And Various Psychotherapies, Brittney L. Benson Jan 2018

Childhood Trauma: An Analysis Of Associated Co-Morbidities And Various Psychotherapies, Brittney L. Benson

Physician Assistant Scholarly Project Posters

American and European studies suggest that anywhere from 14 to 67% of children have experienced at least one traumatic event throughout their life. Furthermore, about 13.4% of them go on to develop post-traumatic stress disorder (PTSD) or symptoms (Diehle, J., Opmeer, B.C., Boer, F., Mannarino, A.P., & Lindauer, R.J., 2015). One study suggests that as many as 63.9% of adults suffer from ACEs (Adverse Childhood Experiences) (CDC, 2016). The 4th Edition of the Diagnostic and Statistical Manual (DSM-IV) states that PTSD is the most common Axis I disorder in children that are victims of abuse with statistics ranging from 20% …


Treating Peri And Postnatal Depression & Anxiety, Emily M. Stevenson Jan 2018

Treating Peri And Postnatal Depression & Anxiety, Emily M. Stevenson

Physician Assistant Scholarly Project Posters

- The objective of this research is to evaluate the commonly prescribed treatment methods for prenatal and postnatal depression, focusing on the efficacy of antidepressant medications and nonpharmacologic treatments while evaluating the effects these medications have on the fetus/breastfeeding infant.

- The method of research included 15 studies completed within the past ten years on women who were pregnant or who had delivered a baby within the past 12 months. One study did evaluate long-term effects on offspring, which included a participant number of 3,342 children who were exposed to antidepressants during pregnancy. The total number of participants in the …


Exercise In The Treatment Of Major Depressive Disorder, Larissa Ann Haug Jan 2018

Exercise In The Treatment Of Major Depressive Disorder, Larissa Ann Haug

Physician Assistant Scholarly Project Posters

Objective

The purpose of this systematic literature review is to determine how exercise can be incorporated into the treatment of major depressive disorder (MDD) and its efficacy.

Methods

In this review, four databases were searched including SportDiscus, Pubmed, Cochrane Database of Systematic Reviews, and PsycInfofrom October 1 to January 5, 2018. A variety of key terms were used when searching. Works chosen for review were published after the year 2000, were peer reviewed, and included randomized control trials (RCTs), pilot studies, systematic reviews, and meta-analyses. Sources that were excluded included those published prior to the year 2000, had poor study …


Scope Of Advance Practice Providers' Role In Transition To Adulthood Care, Cathy Cartwright, Teresa Hickam Jan 2018

Scope Of Advance Practice Providers' Role In Transition To Adulthood Care, Cathy Cartwright, Teresa Hickam

Posters

Advance Practice Providers adopting formal transition planning provided a wider scope of responsibilities supporting transition to adult care than those who did not.


Intensive Referral To Mutual-Help Groups: A Field Trial Of Adaptations For Rural Veterans, Kathleen M. Grant, Lance Brendan Young, Kimberly A. Tyler, Jamie L. Simpson, R. Dario Pulido, Christine Timko Jan 2018

Intensive Referral To Mutual-Help Groups: A Field Trial Of Adaptations For Rural Veterans, Kathleen M. Grant, Lance Brendan Young, Kimberly A. Tyler, Jamie L. Simpson, R. Dario Pulido, Christine Timko

Department of Sociology: Faculty Publications

Objective: A multisite field trial testing whether improved outcomes associated with intensive referral to mutual help groups (MHGs) could be maintained after the intervention was adapted for the circumstances and needs of rural veterans in treatment for substance use disorder (SUD). Methods: In three Veterans Affairs treatment programs in the Midwest, patients (N = 195) received standard referral (SR) or rural-adapted intensive referral (RAIR) and were measured at baseline and 6-month follow-up. Results: Both groups reported significant improvement at 6 months but no significant differences between SR and RAIR groups in MHG participation, substance use, addiction severity, and posttraumatic stress …


Diagnostic Performance Of Blood Inflammatory Markers For Tuberculosis Screening In People Living With Hiv, Katherine Farr, Resmi Ravindran, Luke Strnad, Emily Chang, Leah H. Chaisson, Christina Yoon, William Worodria, Alfred Andama, Irene Ayakaka, Priscilla Bbosa Nalwanga, Multiple Additional Authors Jan 2018

Diagnostic Performance Of Blood Inflammatory Markers For Tuberculosis Screening In People Living With Hiv, Katherine Farr, Resmi Ravindran, Luke Strnad, Emily Chang, Leah H. Chaisson, Christina Yoon, William Worodria, Alfred Andama, Irene Ayakaka, Priscilla Bbosa Nalwanga, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background

Approaches to screening for active tuberculosis (TB) among people living with HIV are inadequate, leading to missed diagnoses and poor implementation of preventive therapy.

Methods

Consecutive HIV-infected adults hospitalized at Mulago Hospital (Kampala, Uganda) between June 2011 and July 2013 with a cough ≥ 2 weeks were enrolled. Patients underwent extensive evaluation for pulmonary TB. Concentrations of 43 cytokines/chemokines were measured at the same time point as C-reactive protein (CRP) in banked plasma samples using commercially-available multiplex kits. Advanced classification algorithms were used to rank cytokines/chemokines for their ability to identify TB, and to model the specificity of the …


The Effect Of A Single-Session Group Songwriting Intervention On Grief Processing In Hospice Clinicians, Melissa Deaton Jan 2018

The Effect Of A Single-Session Group Songwriting Intervention On Grief Processing In Hospice Clinicians, Melissa Deaton

Theses and Dissertations--Music

The purpose of this study was to determine the effect of a single-session group music therapy songwriting session on grief processing in hospice clinicians. The study design was quasi-experimental. Participants were cluster randomized into a control group and a treatment group. The researcher led a 50-minute songwriting session focused on sharing and processing experiences of grief-related stress and burnout in hospice work. Grief processing was measured using a self-report survey for n=25. Overall differences between control and treatment groups were not found to be statistically significant. Significant differences were also not found in treatment score differences for type of …


Rigor And Reproducibility In Research With Transcranial Electrical Stimulation: An Nimh-Sponsored Workshop, Marom Bikson, Andre Brunoni, Leigh Charvet, Vincent Clark, Leonardo Cohen, Zhi-De Deng, Jacek Dmochowski, Dylan Edwards, Flavio Frohlich, Emily Kappenman, Kelvin Lim, Colleen Loo, Antonio Mantovani, David Mcmullen, Lucas Parra, Michele Pearson, Jessica Richardson, Judith Rumsey, Pejman Sehatpour, David Sommers, Gozde Unal, Eric Wassermann, Adam Woods, Sarah Lisanby Jan 2018

Rigor And Reproducibility In Research With Transcranial Electrical Stimulation: An Nimh-Sponsored Workshop, Marom Bikson, Andre Brunoni, Leigh Charvet, Vincent Clark, Leonardo Cohen, Zhi-De Deng, Jacek Dmochowski, Dylan Edwards, Flavio Frohlich, Emily Kappenman, Kelvin Lim, Colleen Loo, Antonio Mantovani, David Mcmullen, Lucas Parra, Michele Pearson, Jessica Richardson, Judith Rumsey, Pejman Sehatpour, David Sommers, Gozde Unal, Eric Wassermann, Adam Woods, Sarah Lisanby

Research outputs 2014 to 2021

Background

Neuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of increasing interest given their potential for manipulating circuits directly. Low intensity transcranial electrical stimulation (tES) with direct currents (transcranial direct current stimulation, tDCS) or alternating currents (transcranial alternating current stimulation, tACS) represent novel, safe, well-tolerated, and relatively inexpensive putative treatment modalities.

Objective

This report seeks to promote the science, technology and effective clinical applications of these modalities, identify research challenges, and suggest approaches for addressing these …


Aging Well: How Subjective Age, Playfulness, And Depression Influence Quality Of Life Among Older Adults, Yvette Saliba El Habre Jan 2018

Aging Well: How Subjective Age, Playfulness, And Depression Influence Quality Of Life Among Older Adults, Yvette Saliba El Habre

Electronic Theses and Dissertations

Given the growing population of aging adults, there is a need for research examining factors that enhance quality of life for older adults (QoL; Colby & Ortman, 2014). Changes in health, relationships, support systems, and social identity are inevitable throughout the lifespan. Therefore, research focused on lessening the negative effects of changes due to aging while also improving QoL is warranted. As such, the aim of the current research study was to examine the extent to which subjective age (SA; how old or young an individual feels), playfulness (PF; "the ability to frame or reframe everyday situations to experience them …


Alcohol Policy Initiatives Of Post-Secondary Institutions In The State Of Kentucky: An Evaluation Of Best Practice Strategies To Reduce Binge Drinking, Deniece Bell Jan 2018

Alcohol Policy Initiatives Of Post-Secondary Institutions In The State Of Kentucky: An Evaluation Of Best Practice Strategies To Reduce Binge Drinking, Deniece Bell

Online Theses and Dissertations

Binge drinking has become a matter of public health. The legal drinking age is 21 in the United States; however, binge drinking by underage college students is prevalent, alarming, and consequential (Malloy & Goldman, 2002). This polarizing topic has caused great concern among policy makers, legal experts, constituents and organizations alike, and as a result they have acted with a sense of urgency to implement policies and evidence-based recommendations for prevention and treatment (U. S. Department of Health and Human Services Alcohol and Health, 1990).

The purpose of this study was to examine the current alcohol policy initiatives among four …


The Effect Of Breastfeeding And Rooming-In Care On Neonatal Abstinence Syndrome, Rachel Boyer, Lindsay Gal, Mahaylie Cline Jan 2018

The Effect Of Breastfeeding And Rooming-In Care On Neonatal Abstinence Syndrome, Rachel Boyer, Lindsay Gal, Mahaylie Cline

Williams Honors College, Honors Research Projects

Concurrent with a rise in opioid abuse during pregnancy is an increase in the number of babies born with Neonatal Abstinence Syndrome (NAS). Despite this crisis, no single treatment has been identified for NAS. This paper sought to analyze and synthesize research evaluating the effectiveness of breastfeeding and rooming-in care on the need and length of pharmacologic treatment and length of hospital stay for neonates with NAS. Twenty-six peer reviewed research articles published between 2006 and 2017 were selected from PubMed and CINAHL for analysis. The studies focused on neonates with NAS born to mothers addicted to opioids or undergoing …


Calling Attention To The Growing Heroin Epidemic And How To Fight It, Kendal Rozaieski Jan 2018

Calling Attention To The Growing Heroin Epidemic And How To Fight It, Kendal Rozaieski

Williams Honors College, Honors Research Projects

The purpose of this study was to explore the experience of creating a grassroots heroin awareness organization on a university campus through qualitative research. Various meeting types were attended as the grassroots efforts began: a student organization dedicated to the cause, the campus Alcohol and Other Drug Board, a local community treatment center agency, multiple University of Akron faculty members, and other heroin awareness groups in the community. Through observation and journaling of these meetings, I am sharing my experience based off analyzed field notes. After analyzation of these notes, common themes related to the formation of this kind of …


Anxious?: Re-Designing Women’S Jewelry To Help Manage Symptoms Of Anxiety Disorders, Nourbanu Feras Hijazi Jan 2018

Anxious?: Re-Designing Women’S Jewelry To Help Manage Symptoms Of Anxiety Disorders, Nourbanu Feras Hijazi

Theses and Dissertations

Anxiety is a common and often stigmatized condition. Destigmatizing mental disorders can positively impact people’s interaction and communication with others and can prompt conversations in which people share their experiences with mental health, leading to improved societal understanding and perception.

My design solution tackles behavioral symptoms of anxiety, specifically two conditions that fall under obsessive-compulsive behavior: Dermatillomania and Trichotillomania. By redesigning women’s jewelry to specialized accessories, my intention is for these objects to help destigmatize these conditions and relieve symptoms of maladaptive behaviors and hurtful impulses. By redirecting these irresistible urges to an external artifact, the objects are designed to …


A Sensory-Based Program To Enhance Occupational Performance For Dementia, Naomi Grace Wong, Jacob Joseph Gantan, Ivy Annahi Torres-Flores, Heather Anne August Jan 2018

A Sensory-Based Program To Enhance Occupational Performance For Dementia, Naomi Grace Wong, Jacob Joseph Gantan, Ivy Annahi Torres-Flores, Heather Anne August

Student Research Posters

Dementia is a neurological disease, causing behavioral and cognitive symptoms, that progressively impairs an individual’s ability to engage in meaningful activities. Progressive deterioration associated with dementia impacts occupational performance and independence and quality of life. Sensory based interventions, such as drumming groups, have been hypothesized to be a non-pharmacological intervention for individuals with dementia. The purpose of this study was to analyze the effects of a sensory based intervention program, in this case participation in a drumming group, on functional engagement during self-feeding for individuals with dementia. Researchers gathered data over the course of two days using the Functional Behavior …


Veterans Court: Examining The Effectiveness Of Veteran-Specific Rehabilitation, Rochelle Sundeen Diconti Jan 2018

Veterans Court: Examining The Effectiveness Of Veteran-Specific Rehabilitation, Rochelle Sundeen Diconti

EWU Masters Thesis Collection

Due to the growing percentage of mental health illnesses related to combat trauma and traumatic brain injuries, the rates of incarceration, suicide, and substance use disorders are skyrocketing in the returning veteran population. The Veterans Court program directs veterans with certain criminal issues into a program designed to treat veterans in need, as opposed to incarcerating them. The purpose of this study is to conduct an initial examination of the effectiveness of this program by measuring four specific factors directly linked to veteran trauma and mental health. I included measures of problematic-anger, shame, thriving, and veteran-specific reintegration issues. Data was …


Day-Level Associations Between Substance Use And Hiv Risk Behavior Among A Diverse Sample Of Transgender Women, Brett M. Millar, Devin English, Raymond L. Moody, H. Jonathon Rendina, Demetria Cain, Nadav Antebi-Gruszka, Joseph A. Carter, Jeffrey T. Parsons Jan 2018

Day-Level Associations Between Substance Use And Hiv Risk Behavior Among A Diverse Sample Of Transgender Women, Brett M. Millar, Devin English, Raymond L. Moody, H. Jonathon Rendina, Demetria Cain, Nadav Antebi-Gruszka, Joseph A. Carter, Jeffrey T. Parsons

Publications and Research

Purpose: Transgender women in the United States face elevated rates of HIV and of substance use. Studies measuring overall or aggregate levels of substance use have linked use to increased HIV transmission risk behavior (TRB). Although intensive longitudinal studies in other populations have found day-level links between substance use and TRB, no study has yet explored such links among transgender women. This study aimed to fill this gap in the literature.

Methods: Utilizing survey and 60-day timeline follow-back interview data from a sample of 214 transgender women in New York City, we tested whether day-level heavy drinking, marijuana use, and/or …


The Impact Of Schizophrenia On Copd Readmission Rate Among Hospitalized South Carolinians, Emilienne Y. Watonsi Jan 2018

The Impact Of Schizophrenia On Copd Readmission Rate Among Hospitalized South Carolinians, Emilienne Y. Watonsi

DNP Research Projects

Due to elevated readmission costs, the Affordable Care Act established the Hospital Readmission Reduction Program in 2012 to curb the 30-day readmission rates. COPD and schizophrenia are two very expensive diseases, COPD national medical costs is projected to be $49.0 billion in 2020; the cost of schizophrenia was 155.7 billion in 2013. The main objective of this study was to determine if schizophrenia is a significant predictor of 30-day readmission following hospitalization for acute exacerbation of COPD after adjusting for age, gender, anxiety, smoking status, T2DM, chronic ischemic heart disease, and GERD. Methods: A retrospective cohort design was used to …


The Lived Experiences Of Opioid Withdrawal: A Phenomenological Study, Eliza Mall Jan 2018

The Lived Experiences Of Opioid Withdrawal: A Phenomenological Study, Eliza Mall

DNP Research Projects

The United States is in the midst of an opioid overdose epidemic resulting to 40,000 accidental drug overdose deaths. In 2016, the number of deaths related to opioid overdose increased to 116 people per day resulting to $504 billion in economic costs. This research study explored the lived experiences of drug addicts having experienced opioid withdrawal symptoms. Phenomenology is useful in discovering the narrative lived experiences that cannot be obtained in quantitative approach. Six themes emerged to describe the lived experiences of opioid addicts who have undergone withdrawal: (a) Increasing desires that are hard to resist (b) Helplessness and hopelessness …


Penalized Mixed-Effects Ordinal Response Models For High-Dimensional Genomic Data In Twins And Families, Amanda E. Gentry Jan 2018

Penalized Mixed-Effects Ordinal Response Models For High-Dimensional Genomic Data In Twins And Families, Amanda E. Gentry

Theses and Dissertations

The Brisbane Longitudinal Twin Study (BLTS) was being conducted in Australia and was funded by the US National Institute on Drug Abuse (NIDA). Adolescent twins were sampled as a part of this study and surveyed about their substance use as part of the Pathways to Cannabis Use, Abuse and Dependence project. The methods developed in this dissertation were designed for the purpose of analyzing a subset of the Pathways data that includes demographics, cannabis use metrics, personality measures, and imputed genotypes (SNPs) for 493 complete twin pairs (986 subjects.) The primary goal was to determine what combination of SNPs and …


Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers Jan 2018

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …


5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala Jan 2018

5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala

Theses and Dissertations

5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens …