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Articles 301 - 330 of 480
Full-Text Articles in Mental and Social Health
Acceptability Of Telepsychiatry In A Rural Kentucky Community Mental Health Clinic, Leslie Brauner
Acceptability Of Telepsychiatry In A Rural Kentucky Community Mental Health Clinic, Leslie Brauner
Doctor of Nursing Practice Projects
While telepsychiatry has been championed as a method to improve access to care and health care delivery to remote regions, the willingness of rural patients to receive psychiatric treatment via telehealth technology remains uncertain (Rohland, Saleh, Rohrer, & Romitti, 2000). Published studies concerning general patient satisfaction with telemedicine are available; however, there is little focus on satisfaction of specialized telepsychiatric care to rural mentally ill adults. A capstone project was conducted to examine the acceptability and satisfaction of telepsychiatry in a rural Kentucky mental health clinic. Patient satisfaction with the modality was assessed using the Telemedicine Satisfaction and Usefulness Questionnaire …
Chhs January 2015 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services
Chhs January 2015 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services
College of Health & Human Services Publications
No abstract provided.
Default Mode Network Segregation And Social Deficits In Autism Spectrum Disorder: Evidence From Non-Medicated Children., Benjamin E Yerys, Evan M Gordon, Danielle N Abrams, Theodore D Satterthwaite, Rachel Weinblatt, Kathryn F Jankowski, John Strang, Lauren Kenworthy, William D. Gaillard, Chandan J Vaidya
Default Mode Network Segregation And Social Deficits In Autism Spectrum Disorder: Evidence From Non-Medicated Children., Benjamin E Yerys, Evan M Gordon, Danielle N Abrams, Theodore D Satterthwaite, Rachel Weinblatt, Kathryn F Jankowski, John Strang, Lauren Kenworthy, William D. Gaillard, Chandan J Vaidya
Psychiatry and Behavioral Sciences Faculty Publications
Functional pathology of the default mode network is posited to be central to social-cognitive impairment in autism spectrum disorders (ASD). Altered functional connectivity of the default mode network's midline core may be a potential endophenotype for social deficits in ASD. Generalizability from prior studies is limited by inclusion of medicated participants and by methods favoring restricted examination of network function. This study measured resting-state functional connectivity in 22 8-13 year-old non-medicated children with ASD and 22 typically developing controls using seed-based and network segregation functional connectivity methods. Relative to controls the ASD group showed both under- and over-functional connectivity within …
Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice
Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice
Computational Modeling & Simulation Engineering Faculty Publications
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at …
Using Interpersonal Process Recall (Ipr) To Examine The Effects Of Equine Assisted Activities On The Personal And Professional Development Of Student Therapists, Dianna Isabel Giraldez
Using Interpersonal Process Recall (Ipr) To Examine The Effects Of Equine Assisted Activities On The Personal And Professional Development Of Student Therapists, Dianna Isabel Giraldez
Department of Family Therapy Dissertations and Applied Clinical Projects
The Introduction to Equine Assisted Family Therapy course offered at Nova Southeastern University (NSU) provides Master’s and Doctoral level student therapists the opportunity to learn how to conduct an equine session and how to utilize horses as part of the therapeutic process. Students learn about the underlying theories and framework behind the equine activities and methodology, as well as participate in the equine activities themselves. For the purpose of this study, classroom discussions centered around processing the students’ experiences and were further enriched by viewing photographs and videos that had been taken of the students conducting the equine activities. The …
Hope-Focused Solutions: A Relational Hope Focus Of The Solution-Building Stages In Solution-Focused Brief Therapy, Jenna A. Wilson
Hope-Focused Solutions: A Relational Hope Focus Of The Solution-Building Stages In Solution-Focused Brief Therapy, Jenna A. Wilson
Department of Family Therapy Dissertations and Applied Clinical Projects
The positive psychotherapy focused on for this study is Solution-Focused Brief Therapy (SFBT). Insoo Kim Berg and Yvonne Dolan (2001) once described the essence of Solution-Focused Brief Therapy (SFBT) as the “pragmatics of hope and respect” (p. 1) and despite Berg and Dolan’s declaration of hope’s importance in SFBT, little process research has been published looking at the “pragmatics” of hope in SFBT practice. Hope is seen as a common factor in psychotherapy since the human relationship, also known as the therapeutic alliance, is a foundation of psychotherapy. Hope plays a significant role in every human interaction and it is …
Attachment, Anxiety, And Depression: A Study Of Women In Residential Treatment With Their Children At The Susan B. Anthony Recovery Center (Sbarc) (1995-2010), Gary Miles Forrest
Attachment, Anxiety, And Depression: A Study Of Women In Residential Treatment With Their Children At The Susan B. Anthony Recovery Center (Sbarc) (1995-2010), Gary Miles Forrest
Department of Family Therapy Dissertations and Applied Clinical Projects
The Susan B. Anthony Recovery Center (SBARC) in Pembroke Pines, Florida is a residential center where women live with their children while receiving treatment for a variety of co-occurring substance abuse and mental health issues and while participating in mandatory parenting classes. Unlike most women's residential treatment centers, which address only the woman and her problems, SBARC treats the mother-infant/child dyad. I designed and created a database to examine the data previously available only in the paper client records of over 800 women who received treatment at SBARC from 1995 through 2010 in a previous project. This nonexperimental, retrospective explanatory …
Screening And Brief Intervention For Alcohol Misuse In Older Adults: Training Outcomes Among Physicians And Other Healthcare Practitioners In Community-Based Settings, Constance L. Coogle, Myra G. Owens
Screening And Brief Intervention For Alcohol Misuse In Older Adults: Training Outcomes Among Physicians And Other Healthcare Practitioners In Community-Based Settings, Constance L. Coogle, Myra G. Owens
Forensic Science Publications
Screening and brief intervention (SBI) is increasingly available to older adults who engage in at-risk drinking. This study examined the extent to which SBI training influenced the willingness of healthcare providers in a community-based hospital and other clinical settings to promote the implementation of SBI. Ninety-three healthcare practitioners (primarily physicians, nurses, and social workers) who attended SBI training were asked about their intentions to apply the information in their professional practice, as well as their enthusiasm about recommending the training to others in their profession. Although there were no differences among the professions in terms of commitment to apply the …
The Caregiver–Child Relationship, Youth Mental Health, And Placement Stability In A Child Welfare Sample, Laura A. Rindlaub
The Caregiver–Child Relationship, Youth Mental Health, And Placement Stability In A Child Welfare Sample, Laura A. Rindlaub
Electronic Theses and Dissertations
Objective: Healthy relationships between adolescents and their caregivers have been robustly associated with better youth outcomes in a variety of domains. Youth in contact with the child welfare system are at higher risk for worse outcomes including mental health problems and home placement instability. A growing body of literature points to youth mental health problems as both a predictor and a consequence of home placement instability in this population; the present study aimed to expand our understanding of these phenomena by examining the interplay among the caregiver-child relationship, youth mental health symptoms, and placement change over time. Method: The sample …
Experiences Of Parents Caring For Infants With Rare Scalp Mass As Identified Through A Disease-Specific Blog, Miranda Worthen, Tara Leonard, Thomas Blair, Nalin Gupta
Experiences Of Parents Caring For Infants With Rare Scalp Mass As Identified Through A Disease-Specific Blog, Miranda Worthen, Tara Leonard, Thomas Blair, Nalin Gupta
Faculty Publications
Background: Delayed subaponeurotic fluid collection (DSFC) is a self-limited disorder of unknown etiology characterized by a benign, fluid-filled mass in the subaponeurotic layer of an infant's scalp. While a few case series describe DSFC, the experiences of families whose infants develop this condition have not previously been reported.Methods: We used a disease-specific blog to evaluate the experiences of 69 families affected by DSFC. We identified self-reported clinical features of DSFC and qualitatively analyzed the families' experiences with obtaining a diagnosis and care for their infants.Results: Infants presented in several clinical settings, and multiple diagnostic procedures were administered, including ultrasound (46%), …
Treatment Of Resistant Depression, Brittany Michels
Treatment Of Resistant Depression, Brittany Michels
Physician Assistant Scholarly Project Posters
• Depression is a common and debilitating disease complicated by comorbidities, medication side effects, limited alternative treatment options, and poor patient adherence.
• Currently, clinical practice guidelines are available outlining the indications and treatment options for depression.
• Discussion will involve pathophysiology of the disease process and possible treatments, such as pharmacotherapy, cognitive behavioral therapy and somatic therapy, including electroconvulsive therapy (ECT).
• ECT is widely accepted as an effective treatment for severe refractory depression, but has a negative social stigma despite its effectiveness.
• This paper has shown ECT remains the most effective treatment of severe refractory depression in …
Adverse Cardiovascular Function Secondary To Inappropriate Exogenous Androgenic Anabolic Steroid Usage In Young Adult Males, Nicholle Rothengass
Adverse Cardiovascular Function Secondary To Inappropriate Exogenous Androgenic Anabolic Steroid Usage In Young Adult Males, Nicholle Rothengass
Physician Assistant Scholarly Project Posters
• In today’s society body image and athletic performance are emphasized and influenced by peers’ perception. The inappropriate use of AAS in young males has steadily increased over the past few decades. The purpose of this study is to determine the long-term effects AAS have upon the cardiovascular system. The review of literature will explore studies that identify long-term abuse of injected AAS, which are used by adult male athletes’ ages 18-40 compared to those equivalent male athletes who have never used any form of drugs or steroids and their effects on the cardiovascular system. The researcher plans to analyze …
Use Of Prescription Drugs And Future Delinquency Among Adolescent Offenders, Tess K. Drazdowski, Lena Jäggi, Alicia Borre, Wendy L. Kliewer
Use Of Prescription Drugs And Future Delinquency Among Adolescent Offenders, Tess K. Drazdowski, Lena Jäggi, Alicia Borre, Wendy L. Kliewer
Psychology Publications
Non-medical use of prescription drugs (NMUPD) by adolescents is a significant public health concern. The present study investigated the profile of NMUPD in 1349 adolescent offenders from the Pathways to Desistance project, and whether NMUPD predicted future delinquency using longitudinal data. Results indicated that increased frequency and recency of NMUPD in adolescent offenders are related to some demographic factors, as well as increased risk for violence exposure, mental health diagnoses, other drug use, and previous delinquency, suggesting that severity of NMUPD is important to consider. However, ANCOVA analyses found that NMUPD was not a significant predictor of drug-related, non-aggressive, or …
How Do Perceived Gender Roles Influence The Number Of Attempted Medical Interventions Of Infertile Couples?, Erin Aiello
How Do Perceived Gender Roles Influence The Number Of Attempted Medical Interventions Of Infertile Couples?, Erin Aiello
Theses and Dissertations--Family Sciences
Infertility affects 1 in 8 couples and the literature discusses the emotional effects infertility has on an individual. One option for infertility is to attempt medical interventions and the literature in the field does not explain why some people attempt more interventions than others. Using data from the 2002 National Survey of Family Growth (NSFG), Cycle 6, this quantitative study aims to understand the relationship between traditional gender roles and values and the attempted number of medical interventions by individuals within a relationship experiencing infertility. The results from this study indicate that both males and females that are in relationship …
From Ideas To Efficacy: The Orbit Model For Developing Behavioral Treatments For Chronic Diseases, Susan M. Czajkowski, Lynda H. Powell, Nancy Adler, Sylvie Naar-King, Kim D. Reynolds, Christine M. Hunter, Barbara Laraia, Deborah H. Olster, Frank M. Perna, Janey C. Peterson, Elissa Epel, Josephine E. Boyington, Mary Charlson
From Ideas To Efficacy: The Orbit Model For Developing Behavioral Treatments For Chronic Diseases, Susan M. Czajkowski, Lynda H. Powell, Nancy Adler, Sylvie Naar-King, Kim D. Reynolds, Christine M. Hunter, Barbara Laraia, Deborah H. Olster, Frank M. Perna, Janey C. Peterson, Elissa Epel, Josephine E. Boyington, Mary Charlson
CGU Faculty Publications and Research
Objective: Given the critical role of behavior in preventing and treating chronic diseases, it is important to accelerate the development of behavioral treatments that can improve chronic disease prevention and outcomes. Findings from basic behavioral and social sciences research hold great promise for addressing behaviorally based clinical health problems, yet there is currently no established pathway for translating fundamental behavioral science discoveries into health-related treatments ready for Phase III efficacy testing. This article provides a systematic framework for developing behavioral treatments for preventing and treating chronic diseases. Method: The Obesity-Related Behavioral Intervention Trials (ORBIT) model for behavioral treatment development features …
The Association Between Self-Rated Mental Health Status And Total Health Care Expenditure: A Cross-Sectional Analysis Of A Nationally Representative Sample, Muoi T. Nguyen, Winnie Y. Chan, Courtney Keeler
The Association Between Self-Rated Mental Health Status And Total Health Care Expenditure: A Cross-Sectional Analysis Of A Nationally Representative Sample, Muoi T. Nguyen, Winnie Y. Chan, Courtney Keeler
Nursing and Health Professions Faculty Research and Publications
Both clinical diagnoses and self-rated measures of mental illness are associated with a variety of outcomes, including physical well-being, health utilization, and expenditure. However, much of current literature primarily utilizes clinically diagnosed data.
This cross-sectional study explores the impact of mental illness and health care expenditure using 2 self-rated measures: self-rated measured of perceived mental health status (SRMH) and Kessler Screening Scale for Psychological Distress (K6).
Data from the 2011 Medical Expenditure Panel Survey Household Component, a nationally representative sample of noninstitutionalized individuals (n = 18,295), were analyzed using bivariate χ2 tests and a 2-part model (logistics regression and …
2015 Annual Report, Center For Applied Research On Substance Use And Health Disparities
2015 Annual Report, Center For Applied Research On Substance Use And Health Disparities
Center for Applied Research on Substance Use and Health Disparities Annual Reports
No abstract provided.
No Safe3 Haven Here: Mental Health Assessment Of Women And Children Held In U.S. Immigration Detention, Kathleen A. O'Connor, Claire Thomas-Duckwitz, Guillermina Gina Nuñez
No Safe3 Haven Here: Mental Health Assessment Of Women And Children Held In U.S. Immigration Detention, Kathleen A. O'Connor, Claire Thomas-Duckwitz, Guillermina Gina Nuñez
Departmental Papers (S&A)
No abstract provided.
The Perceived Effects Of Dance For Individuals With Parkinson’S Disease And Healthy Amateurs, Taylor Marie Mastin
The Perceived Effects Of Dance For Individuals With Parkinson’S Disease And Healthy Amateurs, Taylor Marie Mastin
Electronic Theses and Dissertations
The objective of the present study was to compare the effects of dance participation on physical and psychological functioning as perceived by two distinct groups of dancers: dancers with Parkinson's disease (PD) and healthy amateur (HA) dancers. Dancers in the Parkinson's sample group were gathered from participants in the Dance for PD® program, while healthy amateur dancers were recruited from university dance departments and through social media. Both groups were administered measures related to affect, self-efficacy, quality of life, and which aspects of dance classes were most helpful and/or challenging. Several open-ended questions for both groups were included, along with …
Ua68/10/1 Potter College Of Arts & Letters Sociology Publications, Wku Archives
Ua68/10/1 Potter College Of Arts & Letters Sociology Publications, Wku Archives
WKU Archives Collection Inventories
Publications created by and about Sociology. Including Sociology, Anthropology & Social Work while a part of Potter College.
Promoting First Nations, Metis, And Inuit Youth Wellbeing Through Culturally-Relevant Programming: The Role Of Cultural Connectedness And Identity, Claire Crooks, Dawn V. Burleigh, Ashley Sisco
Promoting First Nations, Metis, And Inuit Youth Wellbeing Through Culturally-Relevant Programming: The Role Of Cultural Connectedness And Identity, Claire Crooks, Dawn V. Burleigh, Ashley Sisco
Journal Articles
Objectives: Although culturally relevant programming has been identified as a promising practice for promoting resiliency among First Nations, Métis, and Inuit (FNMI) youth, the specific ways in which these programs contribute to wellbeing are unclear. The Fourth R: Uniting Our Nations programs include an array of strengths-based culturally relevant programs for FNMI youth that have been found to increase wellbeing. The purpose of this study was to explore how culturally relevant programming provides a forum for intrapersonal and interpersonal growth.
Methods: In-depth interviews were conducted with 12 adult FNMI community and education stakeholders who have had extensive involvement with the …
Visual Voices Approved Consent Form, Collyn Baeder, Zoe Hull, Rebecca Masterjohn, Virginia Sedarski, Adrian Jung, Michaela A. Hoffman, Nicole O'Brien
Visual Voices Approved Consent Form, Collyn Baeder, Zoe Hull, Rebecca Masterjohn, Virginia Sedarski, Adrian Jung, Michaela A. Hoffman, Nicole O'Brien
Visual Voices: An Arts-Based Assessment of the Perceived Identity of Aging Maine Residents
Approved project consent form for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents, designed to investigate the topics of perception, identity, and aging.
Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.
This form documents the scope of the project …
Visual Voices Weekly Session Scripts, Collyn Baeder, Zoe Hull, Rebecca Masterjohn, Virginia Sedarski, Adrian Jung, Michaela A. Hoffman, Nicole O'Brien
Visual Voices Weekly Session Scripts, Collyn Baeder, Zoe Hull, Rebecca Masterjohn, Virginia Sedarski, Adrian Jung, Michaela A. Hoffman, Nicole O'Brien
Visual Voices: An Arts-Based Assessment of the Perceived Identity of Aging Maine Residents
Eleven weekly session scripts for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents. This project was designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.
Resilience: A Psychobiological Construct For Pathway Of Suicidality, Amresh Srivastava, Corelee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt
Resilience: A Psychobiological Construct For Pathway Of Suicidality, Amresh Srivastava, Corelee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt
Data and Test Instruments
Absttract: Background and objective Resilience which is a neurobiological and behavioral construct may modulate psychopathological trajectory as a ‘final common pathway’ for suicide behavior. Since it allows people to adapt to adversity and bounce back to normalcy, treatments based upon modifcation of resilience may be a possibility. Objective of this prospective, cross-sectional study was to examine association of resilience and suicidality in individuals with psychiatric disorders attending Regional RMHC, St. Thomas and London. Method We measured level of resilience by using Connor-Davidson scale (CD-RISC, cut-off 60), suicidality by Scale for Impact of Suicidality Management, Assessment and Planning of Care brief …
Evidence Of Distinctive Structural Alterations That Differentiate Adhd Boys With And Without A Comorbid Reading Disability, Dhruman Dilip Goradia
Evidence Of Distinctive Structural Alterations That Differentiate Adhd Boys With And Without A Comorbid Reading Disability, Dhruman Dilip Goradia
Wayne State University Dissertations
Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) are neurodevelopmental disorders that often co-occur. Children with ADHD and co-occurring RD (ADHD/+RD) tend to show greater cognitive deficits than children with ADHD alone (ADHD/-RD). However, the extents to which comorbid RD impact structural alteration in children with ADHD have never been investigated. The overall goal of this study was to assess structural alterations in the subcortical, cortical and white matter that may differentiate ADHD/-RD from ADHD/+RD. The general hypothesis was that ADHD/+RD would show extensive alterations in regions implicated in ADHD than ADHD/-RD as well as show additional abnormalities in …
Building On Social Capital To Improve Health: The Interactional Approach To Community Development, Matthew Charles Tomlin Mr
Building On Social Capital To Improve Health: The Interactional Approach To Community Development, Matthew Charles Tomlin Mr
Student Research – Stevenson Center
Since political scientist, Robert Putnam, (1995) brought the concept of social capital into popular discourse, there has been a surge in debate over its definition, causes, and consequences in a range of social science disciplines. While social capital has been found to support self-rated overall health at the state level (Kawachi et al, 1999), there is still a dearth of data and research on localities in different regions of the country. This study analyzes survey data collected in the United Way of McLean County’s 2014 Community Assessment to better understand the dynamic between social capital and health in one Central …
Understanding Distinctive Beliefs And Perceptions About Depression Among Haitian Men, Darlyne Richardson
Understanding Distinctive Beliefs And Perceptions About Depression Among Haitian Men, Darlyne Richardson
2010-2016 Archived Posters
This is a quantitative analysis exploring the relationship between levels of depression in Haitian men as related to restrictive emotionality, self-reliance, subjective masculine stress, spiritual well-being, and length of time in the United States. The data were obtained from demographic questionnaires and surveys among 90 Haitian men residing in the United States.
Fear Of Fatherhood, Deborah Weatherspoon, Wendy Sponsler, Christopher Weatherspoon, Dorothy Campbell
Fear Of Fatherhood, Deborah Weatherspoon, Wendy Sponsler, Christopher Weatherspoon, Dorothy Campbell
Walden Faculty and Staff Publications
The fatherhood role is influenced by culture, religion, social factors, and economic norms. In Jamaica pregnancy is often treated as a female only event. Women are left to visit their clinics alone and have support from female family members. The man’s focus is providing financial support. In the past fathers were subjected to migrant labor and left their families for long periods. This tradition remained even when they were not working. Today, men are taking on more of the role of fatherhood, becoming involved and supportive and experiencing the privilege of pregnancy though of a secondary nature through their partner’s …
Aids-Related Stigma And Mental Disorders Among People Living With Hiv: A Cross-Sectional Study In Cambodia, Siyan Yi, Pheak Chhoun, Samedy Suong, Carinne M. Brody, Sovannary Tuot
Aids-Related Stigma And Mental Disorders Among People Living With Hiv: A Cross-Sectional Study In Cambodia, Siyan Yi, Pheak Chhoun, Samedy Suong, Carinne M. Brody, Sovannary Tuot
Background: AIDS-related stigma and mental disorders are the most common conditions in people living with HIV (PLHIV). We therefore conducted this study to examine the association of AIDS-related stigma and discrimination with mental disorders among PLHIV in Cambodia.
Methods: A two-stage cluster sampling method was used to select 1,003 adult PLHIV from six provinces. The People Living with HIV Stigma Index was used to measure stigma and discrimination, and a short version of general health questionnaire (GHQ-12) was used to measure mental disorders. Multivariate logistic regression analysis was conducted.
Results: The reported experiences of discrimination in communities …
Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment, Kelly Marie Mcgregor
Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment, Kelly Marie Mcgregor
Wayne State University Dissertations
Antidepressant drugs are widely used but their mechanism of action remains only partially understood. One leading hypothesis holds that a key effect of chronic treatment with a Selective Serotonin Reuptake Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to assess the effects of the classic SSRI fluoxetine on 5-HT1A receptor-mediated autoinhibition. We conducted these experiments in mice expressing the light-sensitive ion channel Channelrhodopsin (ChR) in 5-HT neurons to facilitate their …