Mental and Social Health Commons^™

Design, Synthesis, And Biological Evaluation Of Mu Opioid Receptor Selective Antagonists Bearing Pyrazole And Imidazole Side Chains, Pornprom Klongkumnuankarn

Theses and Dissertations

Opioid Use Disorder (OUD) is one of the major national threats to human health and economic system. Since the opiate substances produce their pharmacological effects mainly at the Mu Opioid Receptor (MOR), the development of potent MOR selective antagonists is imperative. By application of the message-address concept, the novel selective MOR antagonist, NAP was synthesized in our group. The molecular modeling studies of NAP revealed that its MOR selectivity was determined by interactions between the C(6) side chain and the non-conserved residues of the receptor. To enrich our understanding of Structure-Activity Relationship (SAR) of the opioid ligands as well as …

A Qualitative Analysis Of Caregiver Goals For Urban Children With And Without Asthma, Megan M. Carlson

Theses and Dissertations

Pediatric asthma is a major public health concern that disproportionately affects children of color and youth living in low-income, urban areas. The implications for public health, child health, and family functioning necessitates our understanding and addressing experiences by families who are facing barriers within their socio-demographic context in addition to the stressors associated with managing pediatric asthma. The current study applied qualitative methods to interviews with caregivers of children with and without asthma in an effort to more deeply connect with caregivers’ experiences and yield richer information about the intersection of identities as Black caregivers living in an urban setting …

Signaling Mechanism Responsible For 5-Ht2a Receptor Tolerance To Psychedelic Induced Head-Twitch Behavior In Mice, Audrey R. Mcmurtrie

Theses and Dissertations

In recent years, there has been a growing interest in psychedelic compounds stemming from their promising use as therapeutic agents and research tools that can be used to treat and study several neuropsychiatric disorders. Psychedelics have proven useful in a broad range of these diseases - they serve as models for psychosis in schizophrenia but have also had promising results in treating major depressive disorder, anxiety, and other common disorders. Decreased stigmatization surrounding psychedelics has further increased their use in research and clinical settings. In light of these trends and the promising nature of their use, a thorough understanding of …

Can School Be A Source Of Trauma? Assessing Academic Traumatic Stress As A Mechanism Underlying The Health Outcomes Of Black Undergraduate Students, Ebony A. Lambert

Theses and Dissertations

Research examining Black students’ school experiences demonstrates that exposure to oppressive power dynamics in schools may lead to adverse physiological and psychological consequences. Recent conceptualizations in public discourse further posit that traumatic educational experiences, operationalized here as academic trauma or the cumulative toll of adverse and oppressive experiences in academic settings, may influence Black students’ wellbeing even after they have graduated. However, academic trauma has yet to be investigated empirically, and the health contributions of such educational harm remain unstudied. Moreover, little is known about how culturally-relevant personal characteristics (e.g., emotion regulation strategies) influence Black students’ reactivity to academic trauma. …

The Correlation Between Maternal Postpartum Depression And Child Psychopathology, T'Keyah I. Vaughan

Theses and Dissertations

Background: Postpartum depression (PPD) is a phenomenon that affects nearly 10-15% of pregnancies in the US. It is characterized by depressed mood or anhedonia and lasting for more than 2 weeks. PPD changes how moms interact with family members and child-rearing behavior. Depression is a phenomenon that is also known to affect the psychopathology of children. However, the specifics of how postpartum depression impacts children remains controversial. Many studies do not control for major depressive disorder which makes it difficult to disentangle the impact depression has within the first year of life. Furthermore, other PPD risk factors may be confounding …

A Theoretically-Based Mixed Methods Approach To Examining Mental Health Disorders And Help-Seeking Behaviors Among University-Enrolled African American Men, Kofoworola D.A. Williams

Theses and Dissertations

Recent studies show that African American men in college are disproportionately experiencing high levels of psychological distress, increasing their risk of developing mental health symptoms associated with depression and anxiety. Despite being at higher risk for developing mental health symptoms, university-enrolled, African American men are not seeking help even when experiencing high levels of stress and anxiety, impacting their academic performance. The evidence base describing mental health symptom prevalence and evidence-based prevention strategies among university-enrolled, African American men is limited. To that end, this dissertation work utilized a concurrent, mixed methods approach, theoretically-based in the Social Ecological Model (SEM), to …

Black Women And Body Image: Implications Of The Racialized Beauty Aesthetic, Rachel L. Boutte

Theses and Dissertations

Black women have the highest prevalence of overweight and obesity relative to any other demographic group in the United States, however current weight management interventions appear least effective for them. Although several hypotheses have been proposed to explain these outcomes, few studies have collected data to evaluate how well they fit the lived experiences of Black women. In particular, the potential roles of body image and body dissatisfaction in the development and maintenance of overweight and obesity in Black women are not well understood. Extant literature largely reports that Black women are inoculated from body dissatisfaction due to cultural factors, …

What Parents Value Matters: Examining The Association Between Cultural Values, Parenting Styles/Practices, And Child Outcomes, Chen-Yun Wang

Theses and Dissertations

Researchers have identified significant relationships between parenting styles and child outcomes. However, these associations might vary in different cultures because parenting behaviors could link to cultural values. Additionally, understanding the cultural values of parents would help researchers better understand the reasons of parents’ behaviors. Therefore, the purpose of this study was to examine the relationships between parental Asian values, parenting styles, parenting practices, and child outcomes. Parents of preschool-age children (N = 273) from Taiwan completed a series of parenting values and parenting behaviors questionnaires. Teachers rated child prosocial behaviors, modesty, sociability, and impulse control. Results revealed that some domains …

The Mother Domain: A Mediated Model Of Maternal Gatekeepers And Depressed Fathers Among Newlyweds With Children, Clare R. Thomas

Theses and Dissertations

Paternal depression is an understudied topic and research connecting it to maternal gatekeeping is still in its infancy. Research has found that the marriage relationship can be associated with both depression and maternal gatekeeping. This study focuses on how these three areas are related. A subsample of the CREATE project was used including 216 couples, or 432 married parents. Two separate SEM mediational models were tested to examine father depression as a predictor of maternal gatekeeping, with marital instability as the mediator in one model and partner connectedness as the mediator in the other model. Both parent reports were used …

Social Withdrawal And Indices Of Adjustment And Maladjustment In Adolescence: Does Parent Warmth And Extraversion Matter?, Mallory Abigail Millett

Theses and Dissertations

Social withdrawal is often associated with a number of indices of adjustment and maladjustment, but little research exists that attempts to uncover potential protective factors. This study longitudinally examined the moderating role of parent extraversion and parent warmth on the association between two types of social withdrawal (shyness and unsociability) and later indices of adjustment and maladjustment. Participants were 463 families from the flourishing families project. Results showed no longitudinal associations between social withdrawal and later indices of adjustment or maladjustment. However, when parent extraversion was added as a moderator, shyness was positively associated with prosocial behavior for those with …

Coding Rupture Indicators In Couple Therapy (Crict): An Observational Coding Scheme, Annalisa Ward Carr

Theses and Dissertations

The therapeutic alliance, a construct representing agreement and collaboration on therapy goals, therapy tasks, and the emotional bond between client(s) and therapist, is a robust predictor of therapy outcomes in individual, couple, and family therapy. One way to track the therapeutic alliance is through ruptures and repairs. Ruptures are breaks, tensions, or tears in the therapeutic alliance. Ruptures and repairs influence the therapeutic alliance and consequently therapeutic outcomes. Currently, there is a lack of research addressing ruptures and repairs in couple therapy. The first step in researching alliance ruptures is to have a reliable way to assess alliance ruptures. This …

Intrusive Thoughts - Guitar, Voice, & String Quintet, Joseph M. Young

Theses and Dissertations

This four-movement song addresses mental health, specifically that of Obsession Compulsive Disorder and the symptom of intrusive thoughts that are often associated. From the point of view of an individual suffering from OCD, each movement describes the disorder and portrays different stages of dealing with and managing emotions and relationships.

Understanding Structure-Activity Relationship Of Synthetic Cathinones (Bath Salts) Utilizing Methylphenidate, Barkha J. Yadav

Theses and Dissertations

Synthetic cathinones are stimulant drugs of abuse that act at monoamine transporters e.g. the dopamine transporter (DAT) as releasing agents or as reuptake inhibitors. More than >150 new synthetic cathinones have emerged on the clandestine market and have attracted considerable attention from the medical and law enforcement communities.

threo-Methylphenidate (tMP) is an FDA approved drug for the treatment of ADHD and narcolepsy, which also acts as a DAT reuptake inhibitor and is widely abused. tMP and synthetic cathinones share some structural similarities and extensive structure-activity relationship (SAR) studies on tMP have been conducted. However, much less is known about the …

Translational Insights Into The Genetic Etiology Of Mental Health Disorders: Examining Risk Factor Models, Neuroimaging, And Current Dissemination Practices, Jessica L. Bourdon

Theses and Dissertations

Psychiatric genetics is a basic science field that has potential for practical application and effective translation. To date, translational frameworks utilized by this field have been linear (e.g., sequential) in nature, focusing on molecular genetic information. It is proposed that non-linear (e.g., socio-ecological) frameworks are a better way to immediately translate non-molecular genetic information. This dissertation explored the translation of psychiatric genetic information in two ways. First, a survey was sent to academic stakeholders to assess the state of the science regarding the translation of genetic information to the clinical care of mental health disorders. Findings from this indicate a …

Associations Between Ethnic-Racial Identity, Family Factors And Alcohol Problems Among Diverse Emerging Adults, Chloe Walker

Theses and Dissertations

The current study examined how multiple dimensions of ethnic-racial identity (ERI) were associated with alcohol use and alcohol use disorder (AUD) symptoms and how these relations varied by individuals’ ethnic-racial group among 1850 diverse emerging adults (M = 18.46, SD = .38). Further, measurement invariance of the Ethnic Identity Scale-Brief (EIS-B) was tested across Latinx, White, Black, Asian, and Multiracial students. Additionally, alternative models were examined that tested whether family factors (i.e., parent education and family history of alcohol problems) moderated the relations between ERI and alcohol problems to further examine nuances in these relations. Results indicated that the …

Structure-Activity Relationship Studies Of Synthetic Cathinones And Related Agents, Rachel A. Davies

Theses and Dissertations

Synthetic cathinones and related agents represent an international drug abuse problem, and at the same time an important class of clinically useful compounds. Structure-activity relationship studies are needed to elucidate molecular features underlying the pharmacology of these agents. Illicit methcathinone (i.e., MCAT), the prototype of the synthetic cathinone class, exists as a racemic mixture. Though the differences in potency and target selectivity between the positional and optical isomers of synthetic cathinones and related agents have been demonstrated to have important implications for abuse and therapeutic potential, the two MCAT isomers have never been directly compared at their molecular targets: the …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …

Religion In Incarcerated, Jewish, Female Inmates, Marcia Janine Kesner

Theses and Dissertations

This study explored the role religious belief and practice played amongst Jewish, female inmates during their incarceration. A group of ten correctional chaplains who work with Jewish, female, inmates and a comparison group of ten chaplains who work with Protestant, female inmates were interviewed. The study determined the reasons for and benefits of religious observance among these inmates and included assisting in dealing with fear, providing a sense of peace, and deceitful motives for personal gains. Religious practice also assisted inmate populations in healing from trauma, improving self-respect and self-esteem, building support systems, and additionally for Jewish, female inmates constructing …

An Exploration Of The Quality Of Relationship Between Step-Children And Step-Parents Based On Address Term Usage, Sierra R. Payton

Theses and Dissertations

This study aimed to examine address term usage as a communicative component of blended/step-families by examining the address terms that step-children use to address their step-parent and whether address term usage can allude to the quality of relationship reported by step-children within the step-child step-parent relationship. Rowan University undergraduate students (n=67) were recruited to complete questionnaires on address term usage and quality of relationship using the Quality of Relationships Inventory (QRI). Address term usage was the independent variable and was measured using three levels: formal, familiar, and familial. Quality of relationship was the dependent variable and was measured using the …

Stress Of Trying Daily Therapy Interventions, Emily Kathryn Hansen

Theses and Dissertations

This study is focused on clients' daily experiencing of stress, and measures how this stress might affect their implementation of ideas and recommendations from therapy. Typically, clients attend therapy with the intention of making positive changes. Part of the therapeutic process involves clients completing therapeutic work in their daily lives (Conklin, Strunk, Cooper, 2017); however, stressful tasks and other elements often preclude this therapeutic work from occurring (Kazantzis & L'Abate, 2005). In this study we examine which interventions from therapy are most likely to be attempted at home, and the level of stress in making these attempts. A series of …

Difference In Therapeutic Alliance: High-Conflict Co-Parents Vs Regular Couples, Andrea Mae Parady

Theses and Dissertations

The purpose of this research is to explore differences in the therapeutic alliance for High-Conflict Co-Parents (HCC) vs. Regular Couples. Therapeutic alliance refers to the relationship, consisting of a bond, and agreement on the tasks and goals of therapy, between at least two people in the therapeutic relationship. It was hypothesized that HCC clients would have lower therapeutic alliance scores compared to regular couple clients. The results supported this hypothesis. By identifying these differences, more research can be conducted to improve our understanding of how to strengthen the therapeutic alliance with HCC clients, leading to improved treatment of this population.

Therapist Behaviors That Predict The Therapeutic Alliance In Couple Therapy, Bryan C. Kubricht

Theses and Dissertations

Couple therapy is successful in treating relationship distress. However, couple therapy does not benefit everyone. Consequently, it is important to study factors that predict therapeutic success. One such factor is what predicts the development of the therapeutic alliance in couple therapy. The purpose of this study was to code therapist behaviors, therapist warmth, empathy, presence, validation, collaboration, and technique factors (systemically-based techniques and session structure), in the first session of couple therapy to examine their ability to predict two aspects of the therapeutic alliance, between- and within-alliance, after the session for males and females. The hypotheses were tested utilizing multiple …

The Influence Of Therapist-Patient Religious/Spiritual Congruence On Satisfaction With Therapy: A Review Of Research, Tammy E. Henderson

Theses and Dissertations

The goal of this review was to examine the relationship between mental health and religion and/or spirituality. Specifically, it was believed that religion and spiritual congruence had a positive influence on satisfaction with therapy. Indeed, the literature reviewed suggests that therapists should be more open to addressing a patient's religious and/or spiritual beliefs as it could lead to more attuned therapeutic sessions. The importance of congruence between patient and therapist is a factor that can impact the therapeutic alliance, based on the literature, this concept appears to hold true for those that are or are not religiously and/or spiritually inclined.

Cognitive Effects Of Short Duration Short Wavelength Visible Light, Sarah J. Bolton

Theses and Dissertations

This thesis research looks at the effects of short duration, high intensity, short wavelength light with the goal of determining if converting typically white colored lights in breakrooms and bathrooms to blue will cause workers who normally work in a low light environment to be more alert and productive. Sixteen participants were outfitted with Electroencephalography (and Electrooculography (EOG) equipment before being exposed to 200 lux of either 460 nm blue light or D6500 white light for 30 minutes. Afterwards, the light levels were changed to 3.5 lux of D6500 light and the participants were asked to perform six cognitive tests …

Disordered: Conversations About Mental Health And Society, Rachel Brown

Theses and Dissertations

Disordered is a collaborative, participatory street art project designed to destigmatize mental health challenges like depression and anxiety, and reframe health as a societal issue. Through social practice and guerrilla strategies, Disordered intervenes in public spaces, creating conversations, stickers and metal signs to inspire personal, social and political transformations.

Anxious?: Re-Designing Women’S Jewelry To Help Manage Symptoms Of Anxiety Disorders, Nourbanu Feras Hijazi

Theses and Dissertations

Anxiety is a common and often stigmatized condition. Destigmatizing mental disorders can positively impact people’s interaction and communication with others and can prompt conversations in which people share their experiences with mental health, leading to improved societal understanding and perception.

My design solution tackles behavioral symptoms of anxiety, specifically two conditions that fall under obsessive-compulsive behavior: Dermatillomania and Trichotillomania. By redesigning women’s jewelry to specialized accessories, my intention is for these objects to help destigmatize these conditions and relieve symptoms of maladaptive behaviors and hurtful impulses. By redirecting these irresistible urges to an external artifact, the objects are designed to …

Penalized Mixed-Effects Ordinal Response Models For High-Dimensional Genomic Data In Twins And Families, Amanda E. Gentry

Theses and Dissertations

The Brisbane Longitudinal Twin Study (BLTS) was being conducted in Australia and was funded by the US National Institute on Drug Abuse (NIDA). Adolescent twins were sampled as a part of this study and surveyed about their substance use as part of the Pathways to Cannabis Use, Abuse and Dependence project. The methods developed in this dissertation were designed for the purpose of analyzing a subset of the Pathways data that includes demographics, cannabis use metrics, personality measures, and imputed genotypes (SNPs) for 493 complete twin pairs (986 subjects.) The primary goal was to determine what combination of SNPs and …

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …

5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala

Theses and Dissertations

5-HT_2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens …

Longitudinal Relations Between Interparental Conflict And Adolescent Self-Regulation: The Moderating Role Of Attachment To Parents, Lisa Tensmeyer Hansen

Theses and Dissertations

This study used growth curve analysis to investigate associations between interparental conflict, attachment to parents, and adolescent self-regulation outcomes. Using data from 681 families in the Flourishing Families survey obtained in two western U.S. cities, associations between interparental conflict, mother and father attachment, and initial and growth levels of adolescent self-regulation were analyzed across five time points. Adolescent self-regulation showed steady growth across a five-year period during adolescence, suggesting that self-regulation may continue to develop generally throughout adolescence, a finding not revealed in prior research. Adolescent self-regulation increased significantly more in the first city over the five years of the …