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The Effect Of Illicit Drugs On The Cardiovascular And Hormonal Responses In Pregnant Rabbits, Andrea Alana Chambliss

Biological Sciences Theses & Dissertations

The purpose of this study is to determine the effect of acute administration of heroin and ecgonine methyl ester (EME) on renin and atrial natriuretic peptide (ANP) secretion in time dated New Zealand White rabbits. Thirteen rabbits were studied. Arterial blood pressure and pCOz, increased significantly from a control value of 80 ± 8 mmHg and 30 ± 2 mmHg respectively to 93 ± 18 mmHg and 31 ± 1 mmHg. pO₂ decreased from 99 ± 8 mmHg to 90 ± 11 mmHg 10 minutes after heroin administration. EME caused arterial blood pressure to significantly increase from a control …

Potential Associations Among Genetic Markers In The Serotonergic System And The Antisocial Alcoholism Subtype, E. M. Hill, S. F. Stoltenberg, M. Burmeister, M. Closser, R. A. Zucker

Department of Psychology: Faculty Publications

Alcoholism is transmitted in families. The complexity and heterogeneity of this disorder has made it difficult to identify specific genetic correlates. One design with the potential to do so is the family-based association study, in which the frequencies of genetic polymorphisms are compared between affected and nonaffected members. Reduced central serotonin neurotransmission is associated with features of an antisocial subtype of alcoholism, although a primary deficit has not been traced to a particular component. Genetic markers related to the serotonergic system have been identified, located, and cloned. If associations can be discovered, the development process for pharmacotherapy could be facilitated. …

Effect Of Disulfiram On The Urinary Excretion Of 5-Hydroxytryptophol And 5-Hydroxyindoleacetic Acid In Subjects Consuming Serotonin Rich Foods, Amy G. Tordecilla

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of disulfiram and/or serotonin rich foods (SRF) on the urinary excretion of 5-hydroxytryptophol (5-HTOL) and 5-hydroxyindoleacetic acid (5-HIAA) in normal male subjects was investigated. Urine collections were obtained on 1) regular serotonin free diet, 2) SRF, 3) serotonin free diet with disulfiram, and 4) SRF with disulfiram. Urinary excretion of 5-HTOL in ug/gm creatinine during disulfiram administration was 112.0 ± 24.1. Five HTOL (ug/gm creatinine) with disulfiram and SRF increased to 1532 ± 352.0 (p < 0.001). Five-HIAA (mg/g creatinine) before and after SRF was 3.4 ± .44 and 33.1 ± 6.1 respectively, p < 0.001. With disulfiram and SRF the excretion of was 24.2 ± 3.2 mg/g creatinine which was significantly greater than when on the regular diet (p < 0.001) than the excretion on SRF alone (p < 0.05)

Key words: Disulfiram, serotonin, 5-hydroxytryptophol, 5-hydroxyindoleacetic acid, urinary excretion, high performance liquid chromatography, alcoholism

U.S. Women And Hiv Infection, P. Clay Stephens

New England Journal of Public Policy

Women are inadequately provided with HIV services and education and are differentially denied access to these. Divisions of race, ethnicity, economic class, and religion, among others, are compounded by sexual discrimination within each of these categories.

Review of current data on women with AIDS reveals that the reporting methods used convey a false impression that women are not at significant risk. Moreover, the persons indirectly affected by AIDS are predominantly women — mothers, sisters, partners, family members, teachers, and human service workers. Thus, AIDS is more of a women's issue than the statistics imply.

Women, as a gender-defined class, face …

Human Immunodeficiency Virus In Intravenous Drug Users: Epidemiology, Issues, And Controversies, Donald E. Craven

New England Journal of Public Policy

Intravenous drug users are the second most common risk group for acquired immunodeficiency syndrome (AIDS) in the United States, and they account for approximately 25 percent of the cases. Drug users may spread human immunodeficiency virus (HIV) by sharing contaminated drug injection paraphernalia and through sexual contact; women who use drugs can transmit the virus to their children. The rapid spread of HIV in this risk group and the fact that intravenous drug users are a source for heterosexual and perinatal transmission underscore the need for immediate intervention. In addition, many drug addicts are poor, have limited career possibilities, and …

Effect Of Disulfiram On The Urinary Excretion Of The Serotonin Metabolites 5-Hydroxytryptophol And 5-Hydroxyindoleacetic Acid In Problem Drinkers, Mark D. Harding

Loma Linda University Electronic Theses, Dissertations & Projects

Problem drinkers (N=7) were given 500mg disulfiram daily for one week. Urine was collected before and after disulfiram intake. 5-Hydroxytryptophol (5-HTOL) was determined by a modification of the method of Davis et al. and adapted to high-performance liquid chromatography (HPLC) with an electrochemical detector setting of 0.75V. 5-Hydroxy-indoleacetic acid (5- HIAA) was determined using the HPLC method of Shihabi et al. (1980). Urinary excretion of 5-HTOL in ug/gm creatinine before and after disulfiram was 25.4± 3.3 and 110.5± 27.1 respectively, p < 0.02. 5-HIAA in mg/gm creatinine before and after disulfiram was 4.9±0.9 and 3.6±0.8 respectively, p > 0.16. The data shows that disulfiram administration alters serotonin metabolism resulting in increased 5-HTOL which is known to increase …

Acute Effects Of Phenytoin And Thioridazine, Alone And Combination, Upon Water Intake And Body Weight Changes In Rats, Miriana Witzig-Krstic

Masters Theses

Concommitant medication of anticonvulsants and psychotropics appears to be predominant among mentally retarded, geriatric, and psychiatric in- and out-patient populations. Despite suggested interaction and toxicity resulting from such combination treatment, substantial data remains unavailable. This study was designed to explore effects of dual treatment of thioridazine

The Effects Of Maternal Administration Of Methadone On Beta-Endorphin Content In The Brain And Pituitary Of The Rat Progeny, Randall L. Braun

Loma Linda University Electronic Theses, Dissertations & Projects

Methadone is often used in the maintenance and detoxification of opioid-dependent pregnant women. This use of methadone during pregnancy is known to be associated with teratogenic effects observed in the progeny. The present study is an attempt to gain insight into possible pathophysiologic mechanism(s) responsible for these teratogenic effects: specifically, a relationship between maternal methadone administration and the content of the endogenous opioid peptide, beta-endorphin, in the brain and pituitary of the rat progeny.

In brief, nulliparous mature female Sprague-Dawley rats received daily injections (5 mg./kg.) of methadone hydrochloride (methadone-treated) or a similar volume of physiological saline (controls), treatment started …

Comparative Effects Of Two Avoidance Paradigms Upon Ethanol Self-Selection, Richard O. Shellenberger Ii

Masters Theses

Twelve adult male rats were given free access to a two bottle free-selection of tap water or a 10% ethanol/tap water solution in the home cage for a period of 140 consecutive days with the alcohol consumption data in the form of mg absolute ETOH/g subject weight collected daily. This study incorporated three stages. Phase I was a 40 day period of alcohol acclimation with alcohol consumption during the second 20 days constituting the baseline consumption rate. Mean baseline alcohol consumption was used to block subjects into three groups. The second phase of the study consisted of an 80 day …

Cortical And Subcortical Interhemispheric Interrelation In The Visual System, George C. Wagner

Masters Theses

No abstract provided.

The Relationship Of Alcohol Consumption In Rats To Morphine And Codeine Intake And The Metabolism Of Dopamine, Hsiu Fen Liu

Loma Linda University Electronic Theses, Dissertations & Projects

The effects of morphine and codeine free-choice alcohol consumption in male Sprague-Dawley rats were studied. Intakes of a 10% alcohol solution in milliliters per 100 gm. of body weight were on recorded weekly. No difference was found in the alcohol intake of rats given either a morphine-supplemented diet (0.01% of the diet) or daily injection of morphine sulfate (2 mg./kg.); however, there was a significant lower intake of water (p < .05) in those rats fed the diet with morphine. Total fluid consumption of both groups given the morphine-supplemented diet and daily injection of morphine sulfate was decreased (p < .05). It was found that morphine did not affect the percentage of total fluid consumed as alcohol or the weight gain.

Two levels of codeine phosphate (10 mg./kg. and 20 mg./kg.) were injected subcutaneously into rats twice a day. It was observed that the codeine significantly decreased alcohol intake in rats …

Effects Of Cocaine, Nicotine And Diet On Voluntary Alcohol Consumption In Rats, Zaida Raquel Cordero Loayza

Loma Linda University Electronic Theses, Dissertations & Projects

The consumption of alcohol is a problem not only in this country (U.S.), but also in many other places in the world. Thus we find the Indians in Peru, Bolivia and other neighboring countries (Ecuador and northern part of Argentina) consuming alcohol to the point that they become alcoholics, in addition to this they also chew coca leaves, plant from which cocaine is extracted.

In an effort to establish the cause for this behavior, we put Sprague-Dawley albino rats on either a poor or good basal diet. Once every other day the rats were injected with a solution of cocaine. …

The Dietary Intake Of Preschool Children Attending The Public Health Clinics In San Bernardino, California, Glendover V. Brown

Loma Linda University Electronic Theses, Dissertations & Projects

Preschool children attending Well Baby Clinics directed by the Public Health Department of San Bernardino, California, were the sub jects in this study. The purpose of the study was (1) to compare the eating pattern and habits of the preschool children attending the San Bernardino Public Health Clinics, (2) to assess any differences in the dietary intake of the three major ethnic groups, namely, Mexican- Americans, Whites, and Blacks, and (3) to determine the adequacy of the dietary intake of the preschool children attending the San Bernardino Clinics. One hundred and seventy-seven subjects in this study included 51 Mexican-Americans, 74 …

Effects Of Dietary Factors And Morphine Administration On Voluntary Alcohol Consumption And Dopamine Metabolism In Rats, Claudia Smithson

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of diet and dietary additives on voluntary alcohol consumption in male Sprague-Dawley rats was studied. Alcohol intake measured weekly and reported as ml of a 10% solution ingested per 100 grams body weight. A four week pre-experimental period was designed to determine individual tendencies to drink and thus to eliminate the high and low drinkers from the study. No difference was found in alcohol intake with either starch or sugar as the carbohydrate source; however, there was a greater weight gain ( p < .025) in those animals consuming sugar-based diets. Rats on poor-quality diets containing minimal amounts of vitamins and minerals continued to gradually increase alcohol consumption during the study. This diet, supplemented with coffee, caused the greatest significant increase in alcohol intake and the lowest weight gains. Addition of coffee to the diets significantly increased alcohol consumption (p< .005) but decreased growth rate (p < .0005) . However, when the poor quality diets were supplemented with vitamins and minerals, alcohol consumption was reduced by about 50% (p < .005) and weight gain was significantly increased (p < .0005).

The daily intraperitoneal administration of morphine sulfate significantly decreased alcohol intake (p < .02) and the per cent of total fluid consumed as alcohol (p < .02) but did not effect water consumption.

An attempt was …

Effects Of Poor Quality Diets With Various Dietary Factors Added And Exposure To Cigarette Smoke On The Voluntary Alcohol Intakes Of Albino Rats, Bonnie Emmerson

Loma Linda University Electronic Theses, Dissertations & Projects

Studies were conducted utilizing albino rats to determine the relationship of voluntary alcohol consumption with various dietary additives and exposure to cigarette smoke in combination with poor quality diets. Male, Sprague-Dawley rats, from weanling age to 100 grams, were given the various experimental diets and a free fluid choice of ten per cent ethanol or tap water. Fluid intakes were recorded and analyzed statistically. Individual variation was common with a generally low level of alcohol consumption when rats were fed a poor quality diet of common United States foods. The addition of caffeinated beverages and/or spices and relish caused increases …

A Review Of Drug Addiction And A Study Of Its Relation To Carbohydrate Metabolism, Eppie Chung Hartsuiker

Loma Linda University Electronic Theses, Dissertations & Projects

The specter of addiction eventually involves everyone of the community. It is a three-fold problem of socio-economic, psychological, and physiological factors. The least understood is the physiological or biochemical aspect of addiction.

It has been postulated that an upset in carbohydrate metabolism may be a biochemical cause of addiction. Several avenues were employed to investigate this possible cause of addiction.

1. A diet survey was conducted and revealed a greater consumption of refined carbohydrates, confections and alcoholic beverages in addicts.

2. Five-hour oral glucose tolerance tests were performed on 7 addicts and 12 non-addicts. These tests revealed that there were decreased glucose …

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Presenting The Diagnosis Of Functional Illness, E. J. Alexander

Henry Ford Hospital Medical Journal

No abstract provided.

Psychotherapy, C. B. Farrar

Henry Ford Hospital Medical Journal

No abstract provided.