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- Keyword
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- ACADM; Inborn error of metabolism; MCAD; Medium-chain acyl-coenzyme A dehydrogenase deficiency; Newborn screening; Octanoylcarnitine (1)
- AMPA; NBQX; myelination; oligodendrocyte; perampanel (1)
- Adolescents (1)
- Allopurinol therapeutic use (1)
- Athletics (1)
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- Autonomic Nervous System Diseases (1)
- Body Mass Index (1)
- Cardiomyopathies (1)
- Childen (1)
- Commander Gene (1)
- Diabetes (1)
- Diabetes Mellitus (1)
- Eating disorders (1)
- Epinepherine (1)
- Fertility (1)
- Gene Commanding Height (1)
- Gene Expression Regulation (1)
- Gene Networks (1)
- Genome (1)
- Genomic Fabric (1)
- Gestational (1)
- Glucose Tolerance Test (1)
- HET0016; antiangiogenic treatments; glioblastoma; magnetic resonance imaging; protein array; vascular parameters (1)
- Heme oxygenase-1 (1)
- Hyaluronan; hyaluronan oligosaccharides; hyaluronidase; microglia; myelination; oligodendrocyte (1)
- Hydration (1)
- Hypoglycemia (1)
- Insulin (1)
- Kidney Cancer (1)
- Nephrectomy (1)
- Publication
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Articles 1 - 12 of 12
Full-Text Articles in Medical Specialties
Rig-I-Like Receptors Direct Inflammatory Macrophage Polarization Against West Nile Virus Infection., Amy E. L. Stone, Richard Green, Courtney Wilkins, Emily A. Hemann, Michael Gale Jr.
Rig-I-Like Receptors Direct Inflammatory Macrophage Polarization Against West Nile Virus Infection., Amy E. L. Stone, Richard Green, Courtney Wilkins, Emily A. Hemann, Michael Gale Jr.
College of Osteopathic Medicine (TUN) Publications and Research
RIG-I-Like Receptors (RLRs) RIG-I, MDA5, and LGP2, are vital pathogen recognition receptors in the defense against RNA viruses. West Nile Virus (WNV) infections continue to grow in the US. Here, we use a systems biology approach to define the contributions of each RLR in the innate immune response to WNV. Genome-wide RNAseq and bioinformatics analyses of macrophages from mice lacking either RLR reveal that the RLRs drive distinct immune gene activation and response polarization to mediate an M1/inflammatory signature while suppressing the M2/wound healing phenotype. While LGP2 functions to modulate inflammatory signaling, RIG-I and MDA5 together are essential for M1 …
Towards A Personalized Cancer Gene Therapy: A Case Of Clear Cell Renal Cell Carcinoma, Dumitru Iacobas, Sanda Iacobas
Towards A Personalized Cancer Gene Therapy: A Case Of Clear Cell Renal Cell Carcinoma, Dumitru Iacobas, Sanda Iacobas
NYMC Faculty Publications
No abstract provided.
Clinical Significance Of A False Positive Glucose Challenge Test In Patients With A High Body Mass Index, A Borja, M Moretti, Nisha Lakhi
Clinical Significance Of A False Positive Glucose Challenge Test In Patients With A High Body Mass Index, A Borja, M Moretti, Nisha Lakhi
NYMC Faculty Publications
OBJECTIVE: To determine if there is an increased maternal or neonatal morbidity in overweight and obese patients with a false positive glucose challenge test (GCT). METHODS: Patients with a body mass index (BMI) >/=25.0 at registration were included in this prospective 36-month study. The study cohort consisted of patients with a false positive (FP) GCT, with two comparison cohorts: those with a (1) screen negative (SN) GCT result and (2) true positive (TP) GCT result. Risks were reported as odd ratios with 95% confidence intervals, with a P/=4000 g in the FP cohort, but this fell short of reaching statistical …
Effect Of Systemic Antioxidant Allopurinol Therapy On Skin Flap Survival, M Ardakani, Kaveh Alizadeh, A Moghadam
Effect Of Systemic Antioxidant Allopurinol Therapy On Skin Flap Survival, M Ardakani, Kaveh Alizadeh, A Moghadam
NYMC Faculty Publications
No abstract provided.
Whole Genome Expression Profiling Associates Activation Of Unfolded Protein Response With Impaired Production And Release Of Epinephrine After Recurrent Hypoglycemia, J Kim, Edmund La Gamma, T Estabrook, N Kudrick, Bistra Nankova
Whole Genome Expression Profiling Associates Activation Of Unfolded Protein Response With Impaired Production And Release Of Epinephrine After Recurrent Hypoglycemia, J Kim, Edmund La Gamma, T Estabrook, N Kudrick, Bistra Nankova
NYMC Faculty Publications
Recurrent hypoglycemia can occur as a major complication of insulin replacement therapy, limiting the long-term health benefits of intense glycemic control in type 1 and advanced type 2 diabetic patients. It impairs the normal counter-regulatory hormonal and behavioral responses to glucose deprivation, a phenomenon known as hypoglycemia associated autonomic failure (HAAF). The molecular mechanisms leading to defective counter-regulation are not completely understood. We hypothesized that both neuronal (excessive cholinergic signaling between the splanchnic nerve fibers and the adrenal medulla) and humoral factors contribute to the impaired epinephrine production and release in HAAF. To gain further insight into the molecular mechanism(s) …
Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, Jiang Liu, Jiang Tian, Muhammad Chaudhry, Nader G. Abraham, Joseph Shapiro
Attenuation Of Na/K-Atpase Mediated Oxidant Amplification With Pnaktide Ameliorates Experimental Uremic Cardiomyopathy, Jiang Liu, Jiang Tian, Muhammad Chaudhry, Nader G. Abraham, Joseph Shapiro
NYMC Faculty Publications
We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic …
221 Newborn-Screened Neonates With Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency: Findings From The Inborn Errors Of Metabolism Collaborative, K Bentler, S Zhai, S Elsbecker, G Arnold, B Burton, J Vockley, C Cameron, S Hiner, M Edick, S Berry, J Thomas, M Dodge, R Singh, S Lakshman, David Kronn, Inborn Errors Of Metabolism Collaborative
221 Newborn-Screened Neonates With Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency: Findings From The Inborn Errors Of Metabolism Collaborative, K Bentler, S Zhai, S Elsbecker, G Arnold, B Burton, J Vockley, C Cameron, S Hiner, M Edick, S Berry, J Thomas, M Dodge, R Singh, S Lakshman, David Kronn, Inborn Errors Of Metabolism Collaborative
NYMC Faculty Publications
Introduction: There is limited understanding of relationships between genotype, phenotype and other conditions contributing to health in neonates with medium-chain acyl-coenzyme A dehydrogenase deficiency (MCADD) identified through newborn screening. Methods: Retrospective analysis of comprehensive data from a cohort of 221 newborn-screened subjects identified as affected with MCADD in the Inborn Errors of Metabolism-Information System (IBEM-IS), a long term follow-up database of the Inborn Errors of Metabolism Collaborative, was performed. Results: The average age at notification of first newborn screen results to primary care or metabolic providers was 7.45 days. The average octanoylcamitine (C8) value on first newborn screen was 11.2 …
Ampa-Kainate Receptor Inhibition Promotes Neurologic Recovery In Premature Rabbits With Intraventricular Hemorrhage, Preeti Dohare, Muhammad T. Zia, Ehsan Ahmed, Asad Ahmed, Vivek Yadala, Praveen Ballabh
Ampa-Kainate Receptor Inhibition Promotes Neurologic Recovery In Premature Rabbits With Intraventricular Hemorrhage, Preeti Dohare, Muhammad T. Zia, Ehsan Ahmed, Asad Ahmed, Vivek Yadala, Praveen Ballabh
NYMC Faculty Publications
Intraventricular hemorrhage (IVH) in preterm infants leads to cerebral inflammation, reduced myelination of the white matter, and neurological deficits. No therapeutic strategy exists against the IVH-induced white matter injury. AMPA-kainate receptor induced excitotoxicity contributes to oligodendrocyte precursor cell (OPC) damage and hypomyelination in both neonatal and adult models of brain injury. Here, we hypothesized that IVH damages white matter via AMPA receptor activation, and that AMPA-kainate receptor inhibition suppresses inflammation and restores OPC maturation, myelination, and neurologic recovery in preterm newborns with IVH. We tested these hypotheses in a rabbit model of glycerol-induced IVH and evaluated the expression of AMPA …
Combination Of Vatalanib And A 20-Hete Synthesis Inhibitor Results In Decreased Tumor Growth In An Animal Model Of Human Glioma, Adarsh Shankar, Asm Iskander, Meenu Jain, Tom Mikkelsen, Austin M. Guo, Ali Arbab
Combination Of Vatalanib And A 20-Hete Synthesis Inhibitor Results In Decreased Tumor Growth In An Animal Model Of Human Glioma, Adarsh Shankar, Asm Iskander, Meenu Jain, Tom Mikkelsen, Austin M. Guo, Ali Arbab
NYMC Faculty Publications
BACKGROUND: Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted effect of vatalanib on GBM growth, we have added a new agent known as N-hydroxy-N'-(4-butyl-2 methylphenyl)formamidine (HET0016), which is a selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis. The aims of the studies were to determine 1) whether the addition of HET0016 can attenuate the unwanted effect of vatalanib on tumor growth and 2) whether the treatment …
Hyaluronidase And Hyaluronan Oligosaccharides Promote Neurological Recovery After Intraventricular Hemorrhage, Govindaiah Vinukonda, Preeti Dohare, Arslan Arshad, Muhammad T. Zia, Sanjeet Panda, Ritesh Korumilli, Praveen Ballabh
Hyaluronidase And Hyaluronan Oligosaccharides Promote Neurological Recovery After Intraventricular Hemorrhage, Govindaiah Vinukonda, Preeti Dohare, Arslan Arshad, Muhammad T. Zia, Sanjeet Panda, Ritesh Korumilli, Praveen Ballabh
NYMC Faculty Publications
Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of the white matter. Hyaluronan (HA) inhibits OPC maturation and complexes with the heavy chain (HC) of glycoprotein inter-α-inhibitor to form pathological HA (HC-HA complex), which exacerbates inflammation. Therefore, we hypothesized that IVH would result in accumulation of HA, and that either degradation of HA by hyaluronidase treatment or elimination of HCs from pathological HA by HA oligosaccharide administration would restore OPC maturation, myelination, and neurological function in survivors with IVH. To test these hypotheses, we used the preterm rabbit model of …
Should Sports Drinks Be Given To Children And Adolescents Engaged In Athletics As An Effective Source Of Hydration?, Zeev W. Rubinson
Should Sports Drinks Be Given To Children And Adolescents Engaged In Athletics As An Effective Source Of Hydration?, Zeev W. Rubinson
The Science Journal of the Lander College of Arts and Sciences
Dehydration in children and adolescents is a major concern for caretakers. Often children are not drinking enough, particularly while participating in physical activity. Utilizing data drawn from pediatricians, nutritionists, and bio-scientists, this paper will examine whether sports drinks are a good source of fluids for the exercising child. The results of the research indicate that the advantages generally associated with sports drinks, to achieve higher body water absorption levels, prevent electrolyte deficits, and maintain proper electrolyte/water concentrations, are reserved for unique circumstances. Sports drink intake should be encouraged only when the child is participating in prolonged physical activity, in intense …
Eating Disorders: The Hidden Hormonal Effect On Fertility, Esther Tessler-Karfunkel
Eating Disorders: The Hidden Hormonal Effect On Fertility, Esther Tessler-Karfunkel
The Science Journal of the Lander College of Arts and Sciences
Women who have a history of eating disorders, specifically anorexia nervosa, are more prone to suffer from infertility. There are several hormones which are the driving force in this system and are therefore responsible for this. Fortunately, there are treatments which can help women with a history of eating disorders to reproduce. Using information found on Pubmed and Touro College’s database, this paper will discuss why the body cannot reproduce when it is lacking proper nutrition, as well as the various dynamics in the human reproductive system which are compromised when the body is not properly nourished.