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Full-Text Articles in Medical Specialties

The Alpha-Adrenergic Stimulation Of Atrial Natriuretic Factor Expression In Cardiac Myocytes Requires Calcium Influx, Protein Kinase C, And Calmodulin-Regulated Pathways, C A. Sei, C E. Irons, A B. Sprenkle, P M. Mcdonough, J H. Brown, C C. Glembotski Aug 1991

The Alpha-Adrenergic Stimulation Of Atrial Natriuretic Factor Expression In Cardiac Myocytes Requires Calcium Influx, Protein Kinase C, And Calmodulin-Regulated Pathways, C A. Sei, C E. Irons, A B. Sprenkle, P M. Mcdonough, J H. Brown, C C. Glembotski

Amy Sprenkle

It has been shown recently that a-adrenergic agonists can stimulate atrial natriuretic factor (ANF) expression in ventricular cardiac myocytes; however, little is known about the intracellular signals mediating this activation. The present study focused on the potential roles of calcium-regulated kinases and calcium influx in the a-adrenergic stimulation of ANF gene expression in ventricular myocardial cell cultures. Myocardial cells maintained for 48 h in serumfree medium supplemented with phenylephrine (PE) possessed up to 15-fold higher levels of ANF peptide and ANF mRNA than control cells. The removal of PE, or the addition of nifedipine, resulted in a rapid decline in …


The Palmer Philosophy Of Chiropractic – An Historical Perspective., Dennis M. Richards Jan 1991

The Palmer Philosophy Of Chiropractic – An Historical Perspective., Dennis M. Richards

Dennis M Richards

This paper presents the Palmer philosophy of chiropractic from an historical viewpoint. It examines how influences in the life of DD Palmer, such as spiritualism, theosophy and magnetic healing helped to shape the chiropractic philosophy expressed by him. It also oulines the philosophy of BJ Palmer, explaining how it may have been influenced by legal challenges to the early pioneers of chiropractic. Contemporary expression of the Palmer philosophy, as articulated by Strang, is also noted.