Medical Specialties Commons^™

Differential Microrna Expression In Glioblastoma As A Therapeutic Target Or Potential Biomarker, Drew Hines, Levi Marcum, Aubrey Strong, Ryan Wade

Channels: Where Disciplines Meet

MicroRNA (miRNA) is an epigenetic factor that plays an important role in the post-transcriptional regulation of gene and protein expression. Recent research has shown that in many types of cancer, differentially expressed levels of certain types of miRNA are significantly correlated with the transformation of and ongoing issues caused by cancer cells. Specifically, in Glioblastoma, one of the most lethal and aggressive human cancers, differential levels of miRNAs contribute to the cell’s lack of pro-apoptotic gene presence and its high resistance to current treatments. Results from current studies could provide information about which microRNAs are differentially expressed in glioblastoma when …

Seventy Million Voices, Makenzie Cochran

The Idea of an Essay

No abstract provided.

The Effects Of Music Therapy On Individuals Suffering From Psychiatric Disorders: A Literature Review And Look Into Future Prospects, Zachary J. Krauss

B.A. in Music Senior Capstone Projects

Music therapy is a field of psychology and psychotherapy that exists under the broad field of study known as expressive arts therapy. This form of therapy is experiential in nature, and it gives participants vehicles through which they can tell their stories and share their emotions while actively exploring their thoughts. Music therapy can be used as a treatment for a myriad of psychological disorders. Anxiety, depression, bipolar disorder, PTSD, and schizophrenia are just a few of the disease states treated with these therapies, and music therapy has been proven to be effective as a treatment for each. In order …

Quality Of Life Among Breast Cancer Survivors: A Review Of Literature, Autumn Sue Hankins, Kaitlyn Elizabeth Pees, Mikalyn Marie Heidish

The Research and Scholarship Symposium (2013-2019)

Background: Each year 124.9 per 100,000 women are diagnosed with breast cancer worldwide (National Cancer Institute, n.d.). While it is a serious diagnosis, with modern screening and early detection, survivorship is higher than ever before. The current five-year survival rate for women diagnosed with cancer worldwide is 89.7% (National Cancer Institute, n.d.). The emphasis of this literature review is to address the perceived quality of life of this population. Purpose: The purpose of this literature review was to determine how women who have survived a diagnosis of breast cancer perceive their quality of life (QOL). Methods: This review examined research …

Mental Illness And The Grace Of God, Laura K. Sjoquist

Bioethics in Faith and Practice

This paper will attempt to address God's grace towards those with mental illnesses. It also attempts to provide direction in response to historical church views towards this population. Through scripture, this paper seeks to emphasize the importance of seeing a person as more than what they physically appear capable of - seeing people through God's eyes.

The Effects Of Square-Stepping Exercise On Risk Of Falling And Balance In Senior Adults, Grace A. Miorelli, Michaela Nelson, Elizabeth A. Sled, Benjamin T. Massa, Mackenzi J. Clemens, Hope E. Mccoll, April D. Crommett

The Research and Scholarship Symposium (2013-2019)

As people age, their body systems gradually deteriorate. Muscle function and the vestibular system slowly deteriorate leading to lower body instability. Older adults who struggle with dizziness and imbalance are more prone to falling. Dizziness and imbalance cause falls, and falls are the leading cause of hospitalization and accidental death in older adults (Shinichi & Tatsuya, 2015). It is possible to prevent and reduce the risk of falls through balance training. It is crucial that older adults take the steps needed to improve their balance and therefore reduce their risk of falling. PURPOSE: To evaluate the effect of a 10-week …

Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, Matthew D. Stryker, Michael Kane, Robert Busch

Excerpts in Pharmacy Research Journal

The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and gain-of-function mutations were first described in 2003. The gain-of-function mutations observed were associated with low-density lipoprotein-cholesterol (LDL-C) levels in the 400’s, in addition to premature cardiovascular disease. Subsequent loss-of-function experiments conducted in mice demonstrated marked reductions in plasma cholesterol levels in the absence of PCSK9. Physiologically, PCSK9 serves as a chaperone protein and functions to reduce low-density lipoprotein (LDL) receptor recycling; consequently, less LDL-C is removed from circulation and serum lipid concentrations become elevated. Inhibition of PCSK9 prevents LDL receptor degradation and preserves receptor recycling to the hepatocyte surface; this in …

The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson

The Research and Scholarship Symposium (2013-2019)

Glioblastoma multiforme (GBM) is widely recognized as the most common and lethal of the malignant gliomas. Few effective therapeutic treatments are available as five-year survival rates of diagnosed individuals are less than five percent. Luteolin, a common flavonoid found in a variety of fruits and vegetables, has demonstrated significant promise in combating cancers of the breast, colon, liver, lung, and bone. In this study, we investigated the effects of luteolin on glioblastoma multiforme cell lines U-251, U-87, and U-1242. Cell viability was assessed using cell count with trypan blue exclusion and MTT assays. Results revealed that luteolin reduces GBM cell …

Effects Of High-Fidelity Simulation On Student Perceptions Of Interprofessional Education, Trevor Stump, Mckenzie Shenk, Karissa C. Chow, Becky Brown

The Research and Scholarship Symposium (2013-2019)

Background: Interprofessional education is gaining momentum in healthcare education through the accreditation standards for various health professions and requirements from government initiatives like the Affordable Care Act. The role of high-fidelity simulation in healthcare education is growing and serves as a mechanism to implement interprofessional education.

Purpose: Assess the change in healthcare students’ perceptions of interprofessional education following a high-fidelity emergency medicine simulation.

Methods: Students from a medical, nursing, and pharmacy school participated in a high fidelity simulation event. There was first a brief presentation on interdisciplinary teamwork. The Student Perceptions of Interprofessional Clinical Education-Revised 2 (SPICE-R 2) was administered …

Validation Of Humanized Mouse Antibodies, Meiling G. Norfolk, Rocco J. Rotello

The Research and Scholarship Symposium (2013-2019)

Antibody therapy is being developed and tested as one of the most promising agents for treatment of various human diseases. As of March 2016, 350 antibody candidates are in clinical trials. Many of these antibodies have been taken from animals and “humanized” by genetic modification. Our experiment tests monoclonal antibodies that have been harvested from mouse hybridoma (spleen-derived) cells and cloned until the heavy and light chains of the antibody can be recognized by human cells. Because of this “humanization” procedure, basic antibody assays are needed to demonstrate that the binding, specificity and functional parameters of the antibodies are not …

Chiropractic Physicians' Knowledge Of Pediatric Concussions, Rachel A. Lamb, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Recent legislation in the state of Ohio now allows chiropractic physicians who possess certain credentials to both diagnose and clear young patients who have sustained concussions. Unfortunately, little if any existing research examines the knowledge and abilities of chiropractic physicians regarding the management of this condition. Therefore, the purpose of this study was to provide a general overview of chiropractic physicians’ knowledge regarding the diagnosis and management of pediatric concussions. A survey was emailed to 1,344 chiropractors in the state of Ohio. Of those who were contacted, 71 completed the survey. The survey included questions regarding demographics, patient scenarios, and …

Factors Contributing To Professional Self-Efficacy Levels In Recently Graduated Certified Athletic Trainers, Matthew Kuo, Hannah L. Stedge, Michael S. Weller

The Research and Scholarship Symposium (2013-2019)

Self-efficacy is an important factor for job success, but it has been cited as a missing factor in new athletic training graduates. Therefore, the objective of this study was to find what factors affect the development of self-efficacy in the recently graduated certified athletic trainer. A qualitative survey method was utilized that involved questions aimed to extract as much personal opinion and experiences as possible. Online surveys were sent out electronically to 1,000 prospective participants. A total of 64 survey responses were received but only 52 surveys were qualified for inclusion into the study. Data was collected via the online …

Predictive Value Of The Functional Movement Screen As It Relates To Anterior Cruciate Ligament Injury, Daniel A. Herring, Kyle D. Cherry, Hannah L. Stedge

The Research and Scholarship Symposium (2013-2019)

Introduction: Anterior cruciate ligament injuries occur over 200,000 times annually in the United States alone (Brophy, et al. 2009). This injury strains the healthcare system and affects the players, teams, parents, and the organization they are a part of. There have been, however, clinically researched risk factors that predispose athletes to ACL injury (Gignac, et al. 2015; Laible, et al. 2014). As a result, there is a clinical need for an effective screening tool to identify those athletes at risk for ACL injury. The Functional Movement Screen has been shown to be an effective screening tool for detecting athletes who …

Reducing Perineal Tears: The Effect Of Pushing Methods And Length Of 2nd Stage Of Labor, Kristen A. Mohre, Jessica A. Wall, Chien-Yueh Lee

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Objective: To evaluate the current literature evidence for the effects of either instructed or spontaneous pushing on perineal laceration incidence during delivery and the duration of second stage of labor.

Background: Lacerations (tears) of the perineum are common among women during delivery, increasing pain, infection risk, and other problems for women. Furthermore, prolonged second stage of labor has been shown a risk factor for lacerations. Pushing methods could have an effect on the incidence of lacerations and duration of second stage of labor.

Methods: Thorough search of online databases for the highest levels of evidence relating to the topic within …

Smoking Cessation During Pregnancy: An Evidence Based Practice Protocol, Katherine J. Ruhlman

Master of Science in Nursing Evidence-Based Practice Projects

Intrauterine exposure to nicotine is one of the largest modifiable risk factors for infant morbidity and mortality. Previous progress toward decreasing the number impacted by intrauterine nicotine exposure has recently plateaued. While guidelines for assisting pregnant women to stop smoking are available, few providers have a formalized protocol in place. This project will evaluate most current research evidence regarding smoking cessation during pregnancy in order to develop a formalized protocol for implementation in an obstetric clinic in Southwest Ohio. Reviewed literature was summarized and level of evidence was established. Recommendations were made and categorized as strong, moderate, and weak. The …

Impact Of An Aging Simulation Game On Pharmacy Students’ Empathy For Older Adults, Aleda M.H. Chen, Mary E. Kiersma, Karen S. Yehle, Kimberly S. Plake

Pharmacy Practice Faculty Publications

Objective. To evaluate changes in empathy and perceptions as well as game experiences among student pharmacists participating in an aging simulation game.

Methods. First-year student pharmacists participated in an aging simulation game. Changes were measured pre/post-activity using the Kiersma-Chen Empathy Scale (KCES) and Jefferson Scale of Empathy – Health Professions Scale (JSE-HPS) for empathy and the Aging Simulation Experience Survey (ASES) for perceptions of older adults’ experiences and game experiences. Wilcoxon signed rank tests were used to determine changes.

Results. One hundred fifty-six student pharmacists completed the instruments. Empathy using the KCES and JSE-HPS improved significantly. Of the 13 items …

The Right To A Safe And Healthy Birth, Rebecca D. Neff, Liz C. Widman, Leslie A. Lopez, Brittany M. Cowart, Rebecca L. Aviles

The Research and Scholarship Symposium (2013-2019)

The right to a safe and healthy birth is included in the declaration of human rights- the intrinsic allowances that humans are obligated to be protected by on a global scale. These rights, however, for some pregnant women have been submersed by lack of transportation, education and skilled birth attendants. Financial constraints and difficulty in obtaining adequate healthcare are also issues of concern. A review of literature pertaining to three different countries, the United States, China and India will be examined in light of safe and healthy birthing techniques for women worldwide. These countries were chosen due to their diverse …

Asthma Knowledge, Control, And Administration Techniques In Hispanic Caregivers Of Pediatrics, Kelly J. Wright, Joshua Arnold, Rachel Culp, Kyle Hultz, Benjamin Robertson, Jon Wilkie, Amy Wuobio

The Research and Scholarship Symposium (2013-2019)

Objectives: The objectives of this study were to (1) describe asthma knowledge, control, and administration techniques in Hispanic caregivers of pediatric asthma patients in primary care clinics and (2) determine the association between asthma knowledge and control.

Methods: A pilot, cross-sectional study was conducted by administering a survey to Spanish-speaking primary caregivers of children under 12 years old with a current diagnosis of asthma. The survey contained: demographic questions (8 items), a modified version of the Asthma Control Test (ACT, 5 self-assessment items, 5-point, Likert-type scale), knowledge (21 items, correct/incorrect response), and inhaler use (1 item, rank ordering steps for …

Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens

Martha McMillan Research Papers

No abstract provided.

Influenza And Asthma: Evaluation Of The Effectiveness Of An Evidenced-Based Intervention Bundle On The Influenza Vaccination Rates Among Asthmatic Children Age Six Months To 18 Years, Benjamin D. Malcolm

Master of Science in Nursing Theses

The American Academy of Pediatrics has begun an initiative called Accelerating Improved Care for Children with Asthma Program Chapter Quality Network Asthma Project, Phase 3 (CQN3). This project is a conscious effort to enhance the quality of life in asthmatics. One important initiative included in this project is to achieve 90% or greater influenza vaccination rates in children age six months and older with asthma. This is because children with asthma who contract influenza have increased morbidity and mortality rates than do their non-asthmatic counterparts. Studies have shown vaccination rates for these children are typically between 9 to 26%, and …

Natural Products As Therapeutic Agents In Cancer Treatment, Trevor Stump, Lauren P. Williams, Brittany Santee, Chelsae Ward, Rachel Kunze, Denise S. Simpson, Samson Amos

The Research and Scholarship Symposium (2013-2019)

Cancer accounts for 25% of deaths in the United States, and brain tumors greatly contribute to this percentage. However, relative to other types of cancers, brain tumors prove difficult to treat because they are heterogeneous, highly proliferative, highly invasive, and resistant to the traditional cancer treatments of chemotherapy and radiotherapy. Past studies have shown that flavonoids and curcuminoids, two classes of compounds derived from natural sources, are effective in inhibiting the development and metastasis of breast and lung cancer cells. Research has also indicated that these compounds have potential for treating brain tumors.

The purpose of this research is to …

Skin Preparation For Preventing Infection Following Cesarean Section, Levi Fenton, Alexandra Barford, Adrienne Barnett, Meghan Becker

The Research and Scholarship Symposium (2013-2019)

Abstract

Cesarean section (c-section) is becoming a popular option with 32.8% of the population choosing a surgical procedure over a vaginal delivery. Due to the increase of c-sections, infection rates have risen to a rate of 5.4 infections per 100 c-section operations. Surgical site infections are a large risk for any person having an invasive procedure. In our review of literature, we searched for the most advanced methods to reduce the risk of surgical site infections. We searched for various articles comparing iodine and chlorhexidine and found 14 articles that fit our inclusion criteria. The inclusion criteria consisted of any …

Adherence To Clean Intermittent Catheterization Treatment In Pediatric Patients: A Comprehensive Review Of Literature, Amanda J. Miller, Ashley R. Thompson

The Research and Scholarship Symposium (2013-2019)

No abstract provided.

Health Literacy Influences Heart Failure Knowledge Attainment But Not Self-Efficacy For Self-Care Or Adherence To Self-Care Over Time, Aleda M.H. Chen, Karen S. Yehle, Nancy M. Albert, Kenneth F. Ferraro, Holly L. Mason, Matthew M. Murawski, Kimberly S. Plake

Pharmacy Practice Faculty Publications

Background. Inadequate health literacy may be a barrier to gaining knowledge about heart failure (HF) self-care expectations, strengthening self-efficacy for self-care behaviors, and adhering to self-care behaviors over time. Objective. To examine if health literacy is associated with HF knowledge, self-efficacy, and self-care adherence longitudinally. Methods. Prior to education, newly referred patients at three HF clinics (, age: years) completed assessments of health literacy, HF knowledge, self-efficacy, and adherence to self-care at baseline, 2, and 4 months. Repeated measures analysis of variance with Bonferroni-adjusted alpha levels was used to test longitudinal outcomes. Results. Health literacy was associated with HF knowledge …

Prevention Of Infection In Pin Sites, Sarah Pelletier, Audrey Stearns, Victoria Smith

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

External fixation is a term describing skeletal apparatuses that attach to wire or pins that penetrate the bone, used for complex fractures and limb deformity. 11-100% of patients with external fixation develop some sort of infection. The purpose of this study is to determine whether the measures taken to prevent infection are effective.

Prevention Of Postpartum Depression Related To Mode Of Birth Delivery, Ashley Palumbo, Andrea Vanmeter

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Postpartum depression (PPD) is moderate to severe depression in women after birth. It may occur up to one year after birth, most often in first three months, and affects 10-20% of mothers. Our purpose for reviewing the literature is to identify a potential link between PPD and mode of delivery and to inform the postpartum woman of any increased risk she may have to the development of postpartum depression.

Non-Pharmacological Pain Management Techniques In Neonates, Emily Hudson, Ricky Voetberg, Stephanie Swanson

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Research based evidence supports non-pharmacological techniques for pain management in neonates. Hospitalized neonates undergo multiple painful procedures, and poorly treated pain leads to negative effects in neonates. Pharmacological techniques have many adverse effects. The benefits of non-pharmacological techniques include fewer adverse effects, ease of implementation, and less cost. The purpose of this study is to determine the most effective non-pharmacological technique for reducing procedural pain in neonates.

Effects Of Early Ambulation In Prevention And Treatment Of Vte, Megan Bernstein, Sarah Dolce, Brittany Smith

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

There is a discrepancy in the methods of prevention and treatment of VTE (venous thromboembolism). VTE is a first event in approximately 100 out of 100,000 people. VTE is the synthesis of DVT (deep vein thrombosis), which can ultimately lead to pulmonary embolism, and occurs when a clot forms in the peripheral veins, possibly dislodging and journeying to the lungs. PE (pulmonary embolism) is a blockage in an artery of the lungs and causes permanent tissue damage. 1 in 5 individuals with PE die almost immediately and a further 40% die within three months. PE can develop 3-7 days after …

A Review Comparing The Most Beneficial Regimens Of Cleansing An Umbilical Cord Before Detachment, Caitlyn Seegers, Mary Burkholder, Ellen Moore

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

This review was conducted because an umbilical cord infection is one of the leading causes of death in neonates. “Newborn cord care practices may directly contribute to infections, which account for a large proportion of the four million annual global neonatal deaths (Alam).” Previous studies have shown that there are multiple ways to care for an umbilical cord stub before detachment. Chemical and natural regimens have been proven to be significant in decreasing omphalitis in neonates. One of the most susceptible areas to bacterial colonization for a neonate is the umbilicus. The purpose of this study is to determine the …

The Effectiveness Of Music Therapy In The Pediatric Population, Megan Brewer, Jaclyn Lewis

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Music therapy (MT) is defined as, “the systematic use of music or musical elements-along with the resulting interpersonal relationship with a trained music therapist to achieve optimal health outcomes…” (The Effectiveness, 2010). Nurses are able to implement music therapy in care. Decreasing fear, anxiety, and ultimately pain will enhance the patient’s experience at the hospital and will lessen the burden of performing care on the patient, decrease stress on caregivers, and ease the provision of care on health professionals.