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Full-Text Articles in Medical Specialties
Methylphenidate, Bupropion, And Ssri Triple Therapy, William Bobo M.D.
Methylphenidate, Bupropion, And Ssri Triple Therapy, William Bobo M.D.
Jefferson Journal of Psychiatry
Methylphenidate and bupropion have been demonstrated as being effective adjuncts to serotonin reuptake inhibitors in the treatment of depression (1,2). The use of these medications in case of a depressed patient whose condition was resistant to several forms of monotherapy, monotherapy with "standard" augmentation and ECT. After only a partial response to fluoxetine and methylphenidate, bupropion was added, resulting in full, sustained remission.
Severe Generalized Edema Associated With Phenelzine, William Bobo M.D., Cheryl A. Hemme M.D.
Severe Generalized Edema Associated With Phenelzine, William Bobo M.D., Cheryl A. Hemme M.D.
Jefferson Journal of Psychiatry
Rabkin, et al. describes a 4% incidence of phenelzine-induced edema, which appears to be due to increased capillary permeability (1,2). This adverse effect is not further characterized in the literature and is not readily mentioned as one of the many drug effects that could result in severe physical morbidity. We present the case of a depressed patient who developed a generalized edema severe enough to deserve an extensive medical workup. Once the drug was tapered, the edema and its associated symptoms rapidly resolved.