Medical Specialties Commons^™

The Association Of The G8 Questionnaire With Treatment Side Effects And Unscheduled Care Among Older Breast Cancer Patients: A Retrospective Cohort Study, Sameh Gomaa, Louis Cappelli, Kristine Swartz, Tingting Zhan, Andrew Chapman, Ana Maria Lopez, Joseph Lombardo, Kuang-Yi Wen

Department of Medical Oncology Posters

Introduction

• Nearly half of the patients diagnosed with breast cancer are ≥ 65 years.
• Older patients with breast cancer are at higher risk for experiencing treatment side effects and unplanned health care.
• This can compromise treatment outcomes and increase the cost of care.
• The G8 is among the most sensitive screening tools for frailty and mortality.
• The aim of this study is to evaluate the association of the G8 questionnaire with treatment side effects and unscheduled care in older breast cancer women.

Smoking And Other Determinants Of Covid Severity Among Cancer Patients, Sameh Gomaa, Lindsay Wilde, Md, Tara Rakiewicz, Kuang-Yi Wen

Department of Medical Oncology Posters

Introduction

• Cancer patients might be more susceptible to COVID-19 infection.
• With a higher incidence of acute complications, severe disease and higher mortality rates.
• Identifying factors contributing to severe disease remains essential to avoid the risk of severe and often fatal COVID-19 exposure.
• We report on the predisposing factors for severe COVID-19 and increased hospitalization burden in cancer patients at the Sidney Kimmel Cancer Center (SKCC) in Philadelphia.

Racial Disparities In Diabetes Mellitus Prevalence In Prostate Cancer Patients On Androgen Deprivation Therapy, Sameh Gomaa, William Kelly, Do, Grace Lu-Yao, Phd, Edith Mitchell, Md, Tingting Zhan, Phd, Kuang-Yi Wen, Phd

Department of Medical Oncology Posters

Intro/Background

• Androgen deprivation therapy (ADT) is successfully used in patients with advanced prostate cancer.
• ADT has show to prolong survival.
• The use of ADT is associated with many side effects, most notably an increase in diabetes incidence for patients on ADT.
• African American men have higher prevalence and mortality rates from prostate cancer than White men.
• It is unclear how prostate cancer treatment such as ADT affects these disparities.
• This study examines racial differences in the prevalence of diabetes mellitus in prostate cancer patients based on their ADT status in the US.

The Write Stuff - Summer 2022 (Vol. 19, No. 3), Research Medical Library

Write Stuff 2022

• Next steps after grant rejection
• Resources on new NIH policy for data management and sharing
• What should you include as supplemental material?
• Tips for collaborating with manuscript authors online
• Unusual terms used in scientific writing and publishing: Overlay journal

Evaluating The Impact Of Software Distortion Correction On Target Doses In Cranial Stereotactic Radiosurgery, Sharjil Shamim, Zachary Seymour

Posters

INTRODUCTION
Brainlab’s Elements suite proposed a novel MR distortion correction method based on CT imaging. This involves registration of sub-volumes from MR imaging to generate single continuous deformation field maps, creating a corrected MR image set. No literature currently exists studying the impact of software correction on target dose for cranial stereotactic radiosurgery. In this study, we aim to evaluate the impact of Brainlab distortion correction on radiation target dose compared to original treatment plans without distortion correction.

Development Of A Deep Neural Network For Synthesis Of Non-Contrast Cranial T1-Weighted Magnetic Resonance Imaging, Agueda M. Taylor, Evan Porter, Thomas Guerrero

Posters

INTRODUCTION
Although 122 out of 1000 people in the US have MRI’s done each year, there are over 4 million with contraindications that subsequently forgo the diagnostic benefits. Studies in recent years have implemented artificial intelligence (AI) algorithms such as deep neural networks (DNN) for production of synthetic medical imaging. The goals of this project are to develop a DNN, specifically a Generative Adversarial Network (GAN) that will predict synthetic Cranial T1 Weighted MRI from non-contrast CT, and to evaluate the model quality.

Fluoroscopic Demonstration Of Thoracic Tumor Immobilization With High Frequency Percussive Ventilation, Cristian Solano, Ina M. Sala, Beverly Maurer, Ronald Levitin, Thomas M. Guerrero

Posters

INTRODUCTION
High frequency percussive ventilation (HFPV) is a novel immobilization technique that utilizes high frequency low tidal volume ventilation to produce endotracheal percussion. In a previous departmental study of chest wall motion immobilization, it was found that volunteers were able to tolerate HFPV for varying lengths of time – from a few to tens of minutes. By investigating a novel process to immobilize the chest wall, and thus thoracic tumors, it can allow for more localized radiation delivery and reduction of healthy tissue irradiation.

Dietary Supplement Use Among Brca1/2 Mutation Carriers, Ryan Rogers, Tara Ramgarajan, Virginia Uhley, Kristina Ivan, Dana Zakalik

Posters

INTRODUCTION
Women who carry BRCA1/2 mutations are at significantly increased risk of breast, ovarian, pancreatic and other cancer. Little is known regarding the use of dietary supplements among women harboring BRCA1/2 mutations. This study aims to characterize the utilization of and attitudes toward dietary supplement use in women who carry BRCA1/2 mutations.

The Prognostic Significance Of Glucose-6-Phosphate Dehydrogenase As A Biomarker In Head And Neck Squamous Cell Carcinomas Treated With Conventional Chemoradiation, Kenneth H. Barker, Barbara L. Pruetz, Jessica D. Arden, Thomas J. Quinn, George D. Wilson

Posters

INTRODUCTION
The prognosis of patients with head and neck squamous cell carcinoma (HNSCC) treated with chemoradiation can be predicted using p16 as a surrogate biomarker of Human Papilloma Virus (HPV) status, but a subset of patients continues to do poorly despite a positive or negative p16 status. This project attempted to identify another biomarker, glucose-6-phosphate dehydrogenase (G6PD) as a marker for prognosis in HNSCC patients. Radiation induces oxidative damage to destroy tumor cells, and G6PD is a key enzyme involved in protecting cells from oxidative damage. The goal of this project was to identify a prognostic biomarker that would aid …

Functional Lung Segmentation From Computed Tomography Images Using Deep Learning, Duyen M. Quach, Evan Porter, Thomas M. Guerrero

Posters

INTRODUCTION
Functional avoidance treatment planning allows radiation oncologists to intentionally minimize radiation dose to higher-functioning lung areas while favoring radiation dose towards lower-functioning regions. This treatment planning method has been shown to reduce pulmonary toxicity for patients receiving radiation therapy. Functional lung information, traditionally ventilation or perfusion SPECT scans, is required to plan for functional avoidance.

Treatment Of Recurrent Wilms Tumor With Irinotecan/Temozolomide, Meagan Vacek, Terrie Flatt

Posters

Background: Despite improvement in relapse free survival (RFS) in recurrent Wilms tumor, the 4-year RFS rate for patients treated with vincristine/dactinomycin/doxorubicin is approximately 40%. Ifosfamide, carboplatin and etoposide are commonly used in relapsed solid tumors, but have significant toxicities and require hospital admission for administration. Our patient focused on quality of life, and this led to exploration of other treatment options. Objective: Describe a case of multiply relapsed Wilms tumor with management on oral irinotecan/temozolomide for improved quality of life and remission for almost 1 year. Design/Method: Case Report Results: The patient is an 11-year-old female diagnosed with Wilms tumor …

Memory T Cell Populations In Human Leukemia, Sara Mcelroy, Fang Tao, John Szarejko, John M. Perry

Posters

Background Incorporating the immune system into cancer management is an area of robust research. Treatment modalities aimed at activating cytotoxic T cells against malignancies include immune checkpoint inhibitors, bispecific T-cell engagers, and chimeric antigen receptor (CAR) tumor-specific T cells. Most anti-cancer T cell research is narrowly focused, but knowledge about the nature of diverse sub-populations of T cells in cancer, particularly memory T cells, is vital prior to potential incorporation into therapies. T memory stem cells (Tscm) are of interest due to their longevity and powerful abilities of self-renewal and creating the full spectrum of memory CD8+ T cells, including …

Applying Mci-062, A Novel Pan-Ras Inhibitor, To Treat Kras-Mutant Lung Cancer., Richard Fu

Poster Presentations

Honors thesis poster presentation.

RAS, one of the most prevalent oncogenes, is mutated in 27% of human cancers. Gainof- function RAS mutations activate multiple downstream pathways, including the RASRAF- MEK-ERK and PI3K/AKT/mTOR pathways, which are critical in tumorigenesis and cancer cell proliferation. The RAS proteins KRAS, HRAS, and NRAS along with their downstream effectors are attractive targets for cancer therapy since they act as frequent drivers in lung, colorectal, and pancreatic cancers. However, RAS proteins have relatively smooth surfaces that lack traditional binding pockets, making inhibitors specific to RAS difficult to create. Recently, a novel small molecule pan-RAS inhibitor named …

Analysis Of Role Changes For Women With Breast Cancer Related Lymphedema To Return To Work, Soraya Martinez, Pam Kasyan-Howe, Kristin Domville, Lisa Schubert

Spring 2022 Virtual OTD Capstone Symposium

Breast Cancer survivors diagnosed with secondary lymphedema have decreased quality of life and experience greater challenges when attempting to return to work compared to survivors who do not have secondary lymphedema. Limited research is available in understanding the impact breast cancer-related lymphedema has on survivors transitioning from traditional medical care to return to work. Occupational therapists specializing in Lymphedema therapy have the unique training skills and knowledge to address the challenges this population faces, as well as the tools needed to educate patients and their family members on how to manage returning to work, and make any adaptations to their …

Prostate Cancer Screening Behaviors Among U.S. Immigrants: A Cross-Sectional Analysis Using The Nhis Database, Joshua Linscott, Mathew Hayn, Jesse Sammon, Stephen Ryan

Costas T. Lambrew Research Retreat 2022

Background • The health of immigrants is affected by barriers that challenge all underserved groups, but immigrant-specific factors such as language proficiency and access to physician services are unique and modifiable obstacles that can impede access to quality healthcare. • Immigrants are less likely than the U.S.-born populations to receive screening for breast, cervical, and colorectal cancers. • Patients with limited English proficiency (LEP) are more likely to be diagnosed with advanced stage cancer. • LEP patients with male genitourinary (GU) cancers are 2.58x more likely to be diagnosed at an advanced stage. • Research suggests physicians often do not …

The Write Stuff - Spring 2022 (Vol. 19, No. 2), Research Medical Library

Write Stuff 2022

• New PRISMA guidelines for systematic reviews
• Top tips for writing article titles
• Key points from NIH seminar: “Including diverse populations in NIH-funded clinical research”
• Unusual terms used in scientific writing and publishing: NISO

The Write Stuff - Winter 2022 (Vol. 19, No. 1), Research Medical Library

Write Stuff 2022

• NIH allows flexibility for applicants affected by the COVID-19 pandemic
• Whom to contact for help with your NIH grant applications
• How to write a peer review
• Council of Science Editors launches new podcast
• Unusual terms used in scientific writing and publishing: QWERTY, AZERTY, and Dvorak

The Write Stuff - Autumn 2022 (Vol. 19, No. 4), Research Medical Library

Write Stuff 2022

• Updated guidelines on reporting race and ethnicity in the AMA Manual of Style
• ARRIVE 2.0 and MDAR Framework guide methods reporting for animal research and other life sciences research
• SciScore: A tool to measure reproducibility
• Tips for using figures effectively in grant proposals
• Unusual terms used in scientific writing and publishing: Format-free submission

Psychometric Characteristics And Validity Of The Promis Cancer Function Brief 3d Profile, Sean R. Smith, Mary Vargo, David S Zucker, Samman Shahpar, Lynn Gerber, Maryanne Henderson, Gina Jay, Minji Lee, Andrea Cheville

All Poster Presentations

Purpose: To develop an item response theory (IRT)-calibrated patient-reported outcome measure (PRO) that assesses cancer patient physical function, fatigue and social participation.

Problem Statement: The subspecialty of cancer rehabilitation medicine (CRM) has to date lacked a psychometrically validated patient-reported outcome measure that assesses patients’ physical function, fatigue, and social participation. A significant proportion of the 16.9 million US cancer survivors will experience, or have already experienced, impairments that compromise function, a predictable consequence of their disease and treatment. While each disease site and line of treatment may be associated with unique impairments, there are some that cut across several cancers …

Cancer Care Annual Report 2020-2021, Children's Mercy Kansas City

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Kansas City, a pediatric medical center. This year’s report focuses on Hodgkin Lymphoma.

Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila R. Kunuthuru, Laura Graham, Harry D. Bear Md, Phd

Undergraduate Research Posters

Breast cancer has the highest incidence rate of all cancers globally in women, and those of African descent, especially West African females, face higher rates of triple-negative breast cancer (TNBC), a more aggressive form of breast cancer. Immunotherapy for breast cancer is a relatively new treatment option, and research is ongoing to identify the best combination treatments for increasing survival of those diagnosed with TNBC. Eganelisib (IPI-549: a PI3K-gamma inhibitor that works to shift M2 macrophages to M1 to augment T cell function) with other combinatory treatments has shown promising results in reducing tumor growth and increasing survival in mice. …

Modified Ysk12-Mend-Sirna In Dendritic Cells For Cancer Immunotherapy, Syed S. Alam

Undergraduate Research Posters

Tumors may induce tolerogenesis through signaling dendritic cells to produce tolerogenic molecules, such as indoleamine 2, 3-dioxygenase 1 (IDO1). Tumor-associated immunosuppression is associated with higher mortality in patients. Small interfering RNA (siRNA) has been shown to silence specific target genes in the target cell. The siRNA associated with these genes could support a gene knockdown of these immunosuppressors and reduce mortality. Delivery of these therapeutic nucleic acids is difficult in vivo because siRNA is easily broken down inside the cell and the bloodstream through present nucleases. Use of liposome polymers has been reviewed extensively in literature. YSK12-C4, a lipid nanoparticle …