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Articles 1 - 30 of 52
Full-Text Articles in Medical Specialties
The Diagnostic Performance Of Ultrasonography In The Evaluation Of Extrathyroidal Extension In Papillary Thyroid Carcinoma: A Systematic Review And Meta-Analysis, Peter P. Issa, Aaron L. Albuck, Eslam Hossam, Mohammad Hussein, Mohamed Aboueisha, Abdallah S. Attia, Mahmoud Omar, Seif Abdelrahman, Gehad Naser, Robert D.E. Clark, Eman Toraih, Emad Kandil
The Diagnostic Performance Of Ultrasonography In The Evaluation Of Extrathyroidal Extension In Papillary Thyroid Carcinoma: A Systematic Review And Meta-Analysis, Peter P. Issa, Aaron L. Albuck, Eslam Hossam, Mohammad Hussein, Mohamed Aboueisha, Abdallah S. Attia, Mahmoud Omar, Seif Abdelrahman, Gehad Naser, Robert D.E. Clark, Eman Toraih, Emad Kandil
School of Medicine Faculty Publications
Extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) is an indication of disease progression and can influence treatment aggressiveness. This meta-analysis assesses the diagnostic accuracy of ultrasonography (US) in detecting ETE. A systematic review and meta-analysis were performed by searching PubMed, Embase, and Cochrane for studies published up to April 2022. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. The areas under the curve (AUC) for summary receiver operating curves were compared. A total of 11 studies analyzed ETE in 3795 patients with PTC. The sensitivity of ETE detection was 76% (95%CI = 74–78%). The …
Antibody Epitope Profiling Of The Kshv Lana Protein Using Virscan, Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood
Antibody Epitope Profiling Of The Kshv Lana Protein Using Virscan, Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood
School of Medicine Faculty Publications
The humoral antibody response against Kaposi sarcoma-associated herpesvirus (KSHV) in infected individuals has been characterized demonstrating the latency-associated nuclear antigen (LANA) as the most antigenic KSHV protein. Despite the antigenicity of the protein, specific LANA epitopes have not been systematically characterized. Here, we utilized a bacteriophage T7 library, which displays 56-amino acid KSHV LANA peptides with 28-amino acid overlap (VirScan), to define those epitopes in LANA targeted by antibodies from a cohort of 62 sub-Saharan African Kaposi Sarcoma (KS) patients and 22 KSHV-infected asymptomatic controls. Intra- and inter-patient breadth and magnitude of the anti-LANA responses were quantified at the peptide …
Association Of Brafv600e Mutation With The Aggressive Behavior Of Papillary Thyroid Microcarcinoma: A Meta-Analysis Of 33 Studies, Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil
Association Of Brafv600e Mutation With The Aggressive Behavior Of Papillary Thyroid Microcarcinoma: A Meta-Analysis Of 33 Studies, Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil
School of Medicine Faculty Publications
An association between the BRAFV600E mutation and the clinicopathological progression of papillary thyroid microcarcinoma (PTMC) has been suggested. We aimed to summarize the relevant literature and determine the predictive value of BRAFV600E mutation in predicting clinical outcomes and risk stratification in patients with PTMC. A systematic search using PubMed, Cochrane, and Embase up to February 2020 was performed. A total of 33 studies met the inclusion criteria, resulting in a pool of 8838 patients, of whom 5043 (57.1%) patients were positive for BRAFV600E mutation. Tumors with positive BRAFV600E mutation had a higher tendency for multifocality (RR = 1.09, 95%CI = …
Notch Signaling Pathway: A Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah
Notch Signaling Pathway: A Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf, Sadegh Babashah
School of Medicine Faculty Publications
Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast cancer progression through the abnormal expression of the Notch up-and down-stream effectors. To date, there are only a few patient-centered clinical studies using datasets characterizing the role of Notch signaling pathway regulators in breast cancer; thus, we investigate the role and functionality of these factors in different subtypes using publicly available databases containing records from large studies. High-throughput genomic data and clinical information extracted …
Il-1Β Enhances Cell Viability And Decreases 5-Fu Sensitivity In Novel Colon Cancer Cell Lines Derived From African American Patients, Marzia Spagnardi, Jenny Paredes, Jovanny Zabaleta, Jone Garai, Tiana Reyes, Laura A. Martello, Jennie L. Williams
Il-1Β Enhances Cell Viability And Decreases 5-Fu Sensitivity In Novel Colon Cancer Cell Lines Derived From African American Patients, Marzia Spagnardi, Jenny Paredes, Jovanny Zabaleta, Jone Garai, Tiana Reyes, Laura A. Martello, Jennie L. Williams
School of Medicine Faculty Publications
Background: In the U.S., African Americans (AAs) present with the highest incidence and mortality rates for Colorectal Cancer (CRC). When compared to Caucasian American (CA) patients, AAs also have reduced response to the first line standard of care chemotherapeutic agent 5-Fluorouracil (5-FU). Previously, we observed differential gene expression between the two populations, suggesting that colon tumors from AA patients display a decreased antitumor immune response and an increased expression of genes encoding proteins involved in inflammatory processes, such as Interleukin-1β (IL-1β). Here, we investigate the role of IL-1β in modifying chemotherapeutic response and altering expression of proteins in novel AA …
New Insights Into Avian Infectious Bronchitis Virus In Colombia From Whole-Genome Analysis, Gloria Ramirez-Nieto, Daiana Mir, Diego Almansa-Villa, Geovanna Cordoba-Argotti, Magda Beltran-Leon, Nelida Rodriguez-Osorio, Jone Garai, Jovanny Zabaleta, Arlen P. Gomez
New Insights Into Avian Infectious Bronchitis Virus In Colombia From Whole-Genome Analysis, Gloria Ramirez-Nieto, Daiana Mir, Diego Almansa-Villa, Geovanna Cordoba-Argotti, Magda Beltran-Leon, Nelida Rodriguez-Osorio, Jone Garai, Jovanny Zabaleta, Arlen P. Gomez
School of Medicine Faculty Publications
Infectious Bronchitis (IB) is a respiratory disease caused by a highly variable Gammacoronavirus, which generates a negative impact on poultry health worldwide. GI-11 and GI-16 lineages have been identified in South America based on Infectious Bronchitis virus (IBV) partial S1 sequences. However, full genome sequence information is limited. In this study we report, for the first time, the whole-genome sequence of IBV from Colombia. Seven IBV isolates obtained during 2012 and 2013 from farms with respiratory disease compatible with IB were selected and the complete genome sequence was obtained by NGS. According to S1 sequence phylogenetic analysis, six isolates belong …
Promotion Of A Synthetic Degradation Of Activated Stat6 By Parp-1 Inhibition: Roles Of Poly(Adp-Ribosyl)Ation, Calpains And Autophagy, Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
Promotion Of A Synthetic Degradation Of Activated Stat6 By Parp-1 Inhibition: Roles Of Poly(Adp-Ribosyl)Ation, Calpains And Autophagy, Jeffrey Wang, Mohamed A. Ghonim, Salome V. Ibba, Hanh H. Luu, Yucel Aydin, Peter A. Greer, A. Hamid Boulares
School of Medicine Faculty Publications
Background: We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context of intracellular trafficking and promoter occupancy of the transcription factor on target genes, its integrity in the presence of calpains, and its connection to autophagy. Methods: This study was conducted using primary splenocytes or fibroblasts derived from wild-type or PARP-1−/− mice and Jurkat T cells to mimic Th2 inflammation. Results: We show that the role for PARP-1 in expression of IL-4-induced genes (e.g. gata-3) in splenocytes …
Metabolic Pathways Enriched According To Erg Status Are Associated With Biochemical Recurrence In Hispanic/Latino Patients With Prostate Cancer, Natalia L. Acosta-Vega, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Melody C. Baddoo, Alberto Gómez-Gutiérrez, Silvia J. Serrano-Gómez, Marcela Nuñez Lemus, Martha Lucía Serrano, Jovanny Zabaleta, Alba L. Combita, María Carolina Sanabria-Salas
Metabolic Pathways Enriched According To Erg Status Are Associated With Biochemical Recurrence In Hispanic/Latino Patients With Prostate Cancer, Natalia L. Acosta-Vega, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Melody C. Baddoo, Alberto Gómez-Gutiérrez, Silvia J. Serrano-Gómez, Marcela Nuñez Lemus, Martha Lucía Serrano, Jovanny Zabaleta, Alba L. Combita, María Carolina Sanabria-Salas
School of Medicine Faculty Publications
Background: The role of ERG-status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG-status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients. Methods: RNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA-sequencing. ERGhigh/ERGlow tumor groups were determined based on the 1.5-fold change median expression in non-tumor samples. DEGs with a False Discovery Rate (FDR) < 0.01 and a fold change >2 were identified between ERGhigh and ERGlow tumors and submitted to enrichment analysis in MetaCore. Survival and association analyses were performed …
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle
School of Medicine Faculty Publications
No abstract provided.
Dll3 As An Emerging Target For The Treatment Of Neuroendocrine Neoplasms, James Yao, Emily Bergsland, Rahul Aggarwal, Ana Aparicio, Himisha Beltran, Judy S. Crabtree, Christine L. Hann, Toni Ibrahim, Lauren A. Byers, Hironobu Sasano, John Umejiego, Marianne Pavel
Dll3 As An Emerging Target For The Treatment Of Neuroendocrine Neoplasms, James Yao, Emily Bergsland, Rahul Aggarwal, Ana Aparicio, Himisha Beltran, Judy S. Crabtree, Christine L. Hann, Toni Ibrahim, Lauren A. Byers, Hironobu Sasano, John Umejiego, Marianne Pavel
School of Medicine Faculty Publications
Introduction: Neuroendocrine neoplasms (NEN) are heterogeneous malignancies that can arise at almost any anatomical site and are classified as biologically distinct well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). Current systemic therapies for advanced disease, including targeted therapies, chemotherapy, and immunotherapy, are associated with limited duration of response. New therapeutic targets are needed. One promising target is delta-like ligand 3 (DLL3), an inhibitory ligand of the Notch receptor whose overexpression on the surface of NEN is associated with tumorigenesis. Methods: This article is a narrative review that highlights the role of DLL3 in NEN progression and prognosis, the …
Subtype C Hiv-1 Reservoirs Throughout The Body In Art-Suppressed Individuals, Zhou Liu, Peter Julius, Guobin Kang, John T. West, Charles Wood
Subtype C Hiv-1 Reservoirs Throughout The Body In Art-Suppressed Individuals, Zhou Liu, Peter Julius, Guobin Kang, John T. West, Charles Wood
School of Medicine Faculty Publications
Subtype B HIV-1 reservoirs have been intensively investigated, but reservoirs in other subtypes and how they respond to antiretroviral therapy (ART) is substantially less established. To characterize subtype C HIV-1 reservoirs, we implemented postmortem frozen, as well as formalin fixed paraffin embedded (FFPE) tissue sampling of central nervous system (CNS) and peripheral tissues. HIV-1 LTR, gag, envelope (env) DNA and RNA was quantified using genomic DNA and RNA extracted from frozen tissues. RNAscope was used to localize subtype C HIV-1 DNA and RNA in FFPE tissue. Despite uniform viral load suppression in our cohort, PCR results showed that subtype C …
Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Radiance1: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Rebecca Maitski, Jessica Anderson, Hannah Sibley, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to …
Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano
Predictors Of Equitable Receipt Of Next Generation Sequencing In Endometrial Cancerpatients Receiving Cancer Care In The Deep South, Amber R. Bardarson, Madison A. Keller, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Navya Nair, Andrew Chapple, Tara Castellano
Medical Student Research Poster Symposium
Socioeconomic status remains a predictor of endometrial cancer prognosis and is correlated with advanced disease in patients. Next Generation Sequencing (NGS) provides the ability to prescribe targeted cancer therapies and increases patient survival. Race, ethnicity, and insurance status impact the use of NGS analysis, though the degree of impact remains unclear. An IRB-Approved retrospective research study was performed using data collected of gynecologic cancer patients in a southern healthcare system through use of the electronic medical record (EMR). Baseline clinicopathologic and demographic factors were collected for all endometrial cancer patients. These factors were then tested for significant association on whether …
Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Radiance2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology (GON) referral through adjuvant therapy. A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via means and standard deviations. Categorical covariates were compared across groups using a …
Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart
Nk Cells In Uterine Cancers, Schumann Chang, Vijay Kumar, Caitlin Bauer, John Stewart
Medical Student Research Poster Symposium
Uterine cancer, which includes endometrial cancer (EC) and cervical cancer (CC), is one of the most prevalent gynecologic malignancies amongst women. It is the fourth most common cancer for women in the United States, with more than 90% of uterine cancers occurring in the endometrium. The uterus is a mucosal immune organ that supports embryonic and fetal development. However, its immune microenvironment is continuously altered depending on female sex hormones status, which varies with menstrual cycle and pregnancy. While pregnancy is considered a controlled stage of inflammation, this is not the case in carcinogenesis. This review paper focuses on NK …
Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan
Describing The Prevalence And Unique Demographic And Clinicopathologic Features Of Hpv-Negative Cervical Cancer, Caitlyn C. Gallaspy, Joshua R. Ricks, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia M. Jernigan
Medical Student Research Poster Symposium
HPV-negative cervical cancer (HPV-CC) has been described to represent 10% of cervical cancer cases and to be associated with more advanced presentation and attenuated survival outcomes. The objective of this study was to describe the prevalence of HPV-CC in our region and to compare demographics and clinicopathologic features of HPV-CC to HPV-positive cervical cancer (HPV+CC). A retrospective chart review of patients diagnosed with cervical cancer at a safety-net hospital between January 1, 2015 and December 31, 2020 was conducted. HPV status was determined by HPV testing within 6 months of histologic diagnosis. HPV-CC was defined as a negative HPV test …
Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder
Estrogen, Obesity, And Anticoagulant Protein S Contribute To Thrombosis In Mice, Alaina Guilbeau, Manoj Kumar, Laurent Mosnier, Rinku Majumder
Medical Student Research Poster Symposium
Protein S (PS) is an anticoagulant molecule present in humans and mice. Protein S binds and inhibits coagulation Factor IXa to control thrombin generation1 . Protein S is imperative for normal hemostasis and the prevention of life-threatening thrombotic events, as demonstrated by numerous studies of patients with PS deficiency2,3,4. Pregnant women5 and women who use estrogen-containing birth control pills 6 have lower levels of PS. Thus, it is postulated that estrogen downregulates PS expression in human. Because estrogen is synthesized by aromatase, which is highly expressed in adipose tissue7 , we expected that PS will be downregulated in obese mice …
Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano
Does Mismatch Repair Deficiency Have Similar Prognostic Value For Black Endometrial Cancer Patients Compared To Non-Black Counterparts From The Deep South?, Madison A. Keller, Amber R. Bardarson, Afryea L. Dunbar, Yaseen Khan, Amelia M. Jernigan, Andrew G. Chapple, Navya Nair, Tara Castellano
Medical Student Research Poster Symposium
Introduction: Endometrial cancer (EC) disproportionately affects Black women, but we do not yet know if mismatch repair deficiency (MMRd) has an equal prognostic value in the Black EC population as their White counterparts, due to poor representation of Black patients in scientific studies. We sought to describe the impact of MMRd in a large and racially diverse Southern EC population. Methods: A retrospective cohort study of all EC patients with reported MMR testing receiving care within a large urban healthcare system of both academic and community hospitals was performed from 2018-2022. Chart review was conducted to extract patient demographic, clinicopathologic, …
Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu
Investigating The Role Of Her3 In The Resistance To Egfr Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer, Margaret Larsen, Hui Lyu, Bolin Liu
Medical Student Research Poster Symposium
The majority (80%) of lung cancer patients suffer from non-small cell lung cancer (NSCLC), which has a 5-year survival rate of about 19%. Prior research has shown the importance of studying epidermal growth factor receptor (EGFR) activating mutations to better understand NSCLC. These studies have led to the development of tyrosine kinase inhibitors (TKIs) that target the EGFR mutations to combat tumor growth and metastases. First and secondgeneration EGFR-TKIs are effective in NSCLC patients with the most common EGFR mutations (exon 19 deletion (Del19) and exon 21-point mutation (L858R)); however, resistance in the form of a T790M point mutation has …
Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn
Evaluating Social Vulnerability Impact On Care & Prognosis Of Head & Neck-Nervous System Cancers In The Us, Salim C. Lutfallah, David J. Fel-Zhang, Daniel C. Chelius, Jill N. D'Souza, Jeffery C. Rastatter, Anthony M. Sheyn
Medical Student Research Poster Symposium
Introduction In the current literature, the association between social determinants of health (SDH) and head & neck-nervous system cancer (HNNsC) is limited by the narrow scope of SDH assessed and the broad classifications of HNNsC. Our study utilizes the CDC-Social Vulnerability Index (SVI) to assess both the individual and collective impact of four social determinant themes on various HNNsC in US adults. Methods This retrospective cohort study utilized the SEER database to evaluate 116,373 adult patients from 1975-2017 who presented with various types of HNNsC. Patients were assigned SVI scores based on county-of-residence at the time of diagnosis, encompassing total …
Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Radiance 2: Reducing Delays In Endometrial Cancer Care Gynecologic Oncology Care, Jessica Anderson, Kyla Maupin, Hannah Sibley, Nicole Catalano, Rebecca Maitski, Navya Nair, Tara Castellano, Andrew G. Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: We aimed to identify actionable delays in care that for women with endometrial cancer (EC) from the time of gynecologic oncology referral through adjuvant therapy. Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic, treatment, and survival data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to make a calculation. Categorical covariates were summarized with counts and percentages; continuous variables were summarized via …
Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Radiance: Reducing Delays In Endometrial Cancer Care Symptoms Through Gynecologic Oncology Referral, Hannah Sibley, Jessica Anderson, Rebecca Maitski, Nicole Catalano, Kyla Maupin, Navya Nair, Tara Castellano, Andrew Chapple, Amelia Jernigan
Medical Student Research Poster Symposium
Objective: In this cohort of women seeking care at a university practice in the Gulf South, we aimed to identify specific delays from patient experience of abnormal uterine bleeding (AUB) to referral to gynecologic oncology (GON) with a diagnosis of endometrial cancer (EC). Methods: A multicenter, IRB-approved retrospective chart review was performed. Women diagnosed with Stage I-IV endometrial cancer from 2013 to 2022 were included. Demographic, pathologic and treatment data were collected. Symptom duration and key appointment, procedure, or result dates were recorded. Time frames between key events were calculated. Timed events were censored if there was insufficient data to …
Demographic And Clinical Insight Into The Comorbidities And Mortality Of Patients With Vulvar Cancer Or Dysplasia In Louisiana, Yaseen Khan, Amber R. Bardarson, Afryea L. Dunbar, Madison A. Keller, Amelia Jernigan, Andrew Chapple, Navya Nair, Tara Castellano
Demographic And Clinical Insight Into The Comorbidities And Mortality Of Patients With Vulvar Cancer Or Dysplasia In Louisiana, Yaseen Khan, Amber R. Bardarson, Afryea L. Dunbar, Madison A. Keller, Amelia Jernigan, Andrew Chapple, Navya Nair, Tara Castellano
Medical Student Research Poster Symposium
INTRODUCTION: Studies have shown that vulvar cancer and dysplasia progression is often related to human papillomavirus (HPV) or other conditions. It has been suggested that patients with HPV-related vulvar cancer or dysplasia are likely to have died from a comorbidity rather than from vulvar disease, while patients with vulvar cancer or dysplasia unrelated to HPV often present with more aggressive forms of vulvar disease. The objective of this study was to describe the causes of death in Louisiana patients with vulvar cancer or dysplasia. METHODS: Retrospective analysis of 53 Louisiana patients diagnosed with vulvar cancer or dysplasia between 2013 and …
Racial Disparity In Covid-19 Severity In Prostate Cancer Patients, Austin Noel, Yong Yi, Xiao-Cheng Wu
Racial Disparity In Covid-19 Severity In Prostate Cancer Patients, Austin Noel, Yong Yi, Xiao-Cheng Wu
Medical Student Research Poster Symposium
BACKGROUND: Past research has shown that African American cancer patients with COVID-19 have had higher hospitalization rates when compared to their Caucasian counterparts. Our study focuses on COVID-19 hospitalization rates in patients with prostate cancer. Statistics have shown that African American men are 50% more likely to develop prostate cancer in their lifetime and twice as likely to die from prostate cancer versus Caucasian men. Thus, one speculation is that racial differences in COVID-19 severity among prostate cancer patients are attributable to African American men having a higher prevalence of prostate cancer and greater risk of severe outcome. This study …
Sex Differences In Determinants Of Covid-19 Severe Outcomes – Findings From The National Covid Cohort Collaborative (N3c), Yilin Yoshida, San Chu, Sarah Fox, Yuanhao Zu, Dragana Lovre, Joshua L. Denson, Lucio Miele, Franck Mauvais-Jarvis
Sex Differences In Determinants Of Covid-19 Severe Outcomes – Findings From The National Covid Cohort Collaborative (N3c), Yilin Yoshida, San Chu, Sarah Fox, Yuanhao Zu, Dragana Lovre, Joshua L. Denson, Lucio Miele, Franck Mauvais-Jarvis
School of Medicine Faculty Publications
Objective: The impact of comorbidities and biomarkers on COVID-19 severity vary by sex but have not yet been verified in population-based studies. We examined the association of comorbidities, inflammatory biomarkers, and severe outcomes in men and women hospitalized for COVID-19. Design: This is a retrospective cohort analysis based on the National COVID Cohort Collaborative (N3C). We included 574,391 adult patients admitted for COVID-19 at hospitals or emergency rooms between 01/01/2020 and 12/31/2021. Methods: We defined comorbidities at or before the first admission for COVID-19 by Charlson Comorbidity Index (CCI) and CCI components. We used the averaged lab values taken within …
Employing Respondent Driven Sampling (Rds) To Recruit People Who Inject Drugs (Pwid) And Other Hard-To-Reach Populations During Covid-19: Lessons Learned, Roberto Abadie, Patrick Habecker, Kimberly Gocchi Carrasco, Kathy S. Chiou, Samodha Fernando, Sydney J. Bennett, Aníbal Valentin-Acevedo, Kirk Dombrowski, John T. West, Charles Wood
Employing Respondent Driven Sampling (Rds) To Recruit People Who Inject Drugs (Pwid) And Other Hard-To-Reach Populations During Covid-19: Lessons Learned, Roberto Abadie, Patrick Habecker, Kimberly Gocchi Carrasco, Kathy S. Chiou, Samodha Fernando, Sydney J. Bennett, Aníbal Valentin-Acevedo, Kirk Dombrowski, John T. West, Charles Wood
School of Medicine Faculty Publications
Background: Respondent Driven Sampling (RDS) is an effective sampling strategy to recruit hard-to-reach populations but the impact of the COVID-19 pandemic on the use of this strategy in the collection of data involving human subjects, particularly among marginalized and vulnerable populations, is not known. Based on an ongoing study using RDS to recruit and study the interactions between HIV infection, injection drug use, and the microbiome in Puerto Rico, this paper explores the effectiveness of RDS during the pandemic and provided potential strategies that could improve recruitment and data collection. Results: RDS was employed to evaluate its effectiveness in recruiting …
Ultraviolet Light Exposure Decreases Thyroid Cancer Risk: A National Perspective, Tessa R. Lavorgna, Mohammad Hussein, Peter P. Issa, Eman Toraih, Emad Kandil
Ultraviolet Light Exposure Decreases Thyroid Cancer Risk: A National Perspective, Tessa R. Lavorgna, Mohammad Hussein, Peter P. Issa, Eman Toraih, Emad Kandil
School of Medicine Faculty Publications
Ultraviolet (UV) light has been reported to have both pro-oncogenic and anti-oncogenic effects. Since patient pigmentation can influence the role of UV light exposure, we thought to investigate the recent trends in thyroid cancer incidence and survival with an emphasis on patient race and UV exposure. Patients diagnosed with thyroid cancer from the Surveillance, Epidemiology, and End Results (SEER) database were identified. A total of 284,178 patients were enrolled. Data were stratified according to population sex, race, and state. UV exposure data in Watt-Hours Per Square Meter for the state were obtained from the National Cancer Institute Cancer Atlas. Thyroid …
Radiofrequency Ablation Of Indeterminate Thyroid Nodules: The First North American Comparative Analysis, Peter P. Issa, Mahmoud Omar, Chad P. Issa, Yusef Buti, Mohammad Hussein, Mohamed Aboueisha, Ali Abdelhady, Mohamed Shama, Grace S. Lee, Eman Toraih, Emad Kandil
Radiofrequency Ablation Of Indeterminate Thyroid Nodules: The First North American Comparative Analysis, Peter P. Issa, Mahmoud Omar, Chad P. Issa, Yusef Buti, Mohammad Hussein, Mohamed Aboueisha, Ali Abdelhady, Mohamed Shama, Grace S. Lee, Eman Toraih, Emad Kandil
School of Medicine Faculty Publications
Thyroid nodules can be classified as benign, malignant, or indeterminate, the latter of which make up 10–30% of nodules. Radiofrequency ablation (RFA) has become an attractive and promising therapy for the treatment of benign thyroid nodules. However, few studies have investigated the safety and efficacy of RFA for the management of indeterminate thyroid nodules. In this study, 178 patients with thyroid nodules diagnosed as benign (Bethesda II) or indeterminate (Bethesda III/IV) by preoperative cytopathological analysis were included. Patients in the benign and indeterminate cohorts had similar thyroid nodule volume reduction rates at 65.60% and 64.20%, respectively (p = 0.68). The …
Diagnostic Accuracy Of Ultrasound In Predicting Extrathyroidal Extension And Its Relation To Body Mass Index In A North American Population, Mahmoud Omar, Abdallah S. Attia, Peter P. Issa, Bryce R. Christensen, Kavin Sugumar, Ahmed Alnahla, Deena Hadedeya, Hosam Shalaby, Neel Gupta, Mohamed Shama, Eman Toraih, Emad Kandil
Diagnostic Accuracy Of Ultrasound In Predicting Extrathyroidal Extension And Its Relation To Body Mass Index In A North American Population, Mahmoud Omar, Abdallah S. Attia, Peter P. Issa, Bryce R. Christensen, Kavin Sugumar, Ahmed Alnahla, Deena Hadedeya, Hosam Shalaby, Neel Gupta, Mohamed Shama, Eman Toraih, Emad Kandil
School of Medicine Faculty Publications
Detection of extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) influences treatment plan and surgical aggressiveness. Ultrasound (US) is the long-standing preoperative imaging method of choice. Recent literature from Asia suggests US accuracy to be influenced by patient characteristics, such as body mass index (BMI). Here, we examine the effect of BMI on the accuracy of US at a North American tertiary referral center. A total of 204 PTC-confirmed patients were retrospectively read by a radiologist blinded to surgical pathology findings. The radiologist recorded multiple sonographic features, including ETE, loss of echogenic capsule, nodule vascularity, capsular abutment, and …
Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. Hgould@Lsuhsc.Edu Gould, Dennis Paul
Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. Hgould@Lsuhsc.Edu Gould, Dennis Paul
School of Medicine Faculty Publications
Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are essential for survival. Alterations in the expression of the transmembrane proteins responsible for maintaining ion balance that occur as a result of mutations in the genetic code or in response to iatrogenically induced changes in the extracellular environment is a characteristic feature of oncogenesis and identifies cancer as one of a constellation of diseases known as channelopathies. The classification …