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Regulation Of Glucose Homeostasis By The Phlpp1 Phosphatase, Kara L. Larson
Regulation Of Glucose Homeostasis By The Phlpp1 Phosphatase, Kara L. Larson
Theses and Dissertations--Molecular and Cellular Biochemistry
Type 2 diabetes mellitus is a metabolic disease that affects one in ten people in the United States. It is caused by a combination of genetics and lifestyle factors. Disease progression begins with insulin resistance in peripheral tissues followed by pancreatic beta-cell failure. The mechanisms behind disease progression are not completely understood. PH domain leucine rich repeat protein phosphatase 1 (PHLPP1) is a known regulator of Akt and other members of the AGC kinase family. Akt has been established to play a role in numerous metabolic signaling pathways, including insulin action. It is hypothesized that as a regulator of Akt, …