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Full-Text Articles in Medical Specialties
The Role Of Urinary Modulators In The Development Of Infectious Kidney Stones, Brendan Wallace
The Role Of Urinary Modulators In The Development Of Infectious Kidney Stones, Brendan Wallace
Electronic Thesis and Dissertation Repository
The pathogenesis of infectious kidney stones is poorly understood, while equally unclear is the role of urinary modulators and bacteria. An experimental model was created and utilized to test a variety of urinary modulators and bacterial strains commonly associated with struvite and calcium phosphate stones to evaluate their potential roles in influencing crystal formation. Modulators such as acids, citrate, and osteopontin had strong inhibitory effects on infectious crystal formation while the remaining modulators had neutral, mixed, or positive effects. Lastly, it was determined that the presence of urease may not directly lead to calcium phosphate and struvite stones in all …
The Role Of Coagulase-Negative Staphylococcal Secreted Products On Staphylococcus Aureus And Staphylococcus Lugdunensis Infections, Denny Chin
Electronic Thesis and Dissertation Repository
The Staphylococcus genus is comprised of over 40 bacterial species. The most well-studied species in this genus is the notorious human pathogen Staphylococcus aureus, a bacterium that produces coagulase among many other virulence factors. Since S. aureus is a major health burden and causes a plethora of diseases in humans, it has received significant attention and much research has been done to understand its biology to treat diseases caused by this pathogen. However, the coagulase-negative staphylococci (CoNS) make up most of the staphylococcal species and have received less attention since they are thought to have a lesser impact on …
Ex Vivo Thrombus Magnetic Resonance Imaging Features And Patient Clinical Data Enable Prediction Of Acute Ischemic Stroke Cause, Spencer D. Christiansen, Junmin Liu, Maria Bres Bullrich, Manas Sharma, Sachin K. Pandey, Melfort Boulton, Sebastian Fridman, Luciano A. Sposato, Maria Drangova
Ex Vivo Thrombus Magnetic Resonance Imaging Features And Patient Clinical Data Enable Prediction Of Acute Ischemic Stroke Cause, Spencer D. Christiansen, Junmin Liu, Maria Bres Bullrich, Manas Sharma, Sachin K. Pandey, Melfort Boulton, Sebastian Fridman, Luciano A. Sposato, Maria Drangova
Robarts Vascular Research Publications
The cause of ischemic stroke often remains elusive even after full stroke workup is completed. Cardioembolic mechanisms in particular are frequently presumed but challenging to definitively diagnose. Quantitative thrombus texture analysis is emerging as a powerful tool for stroke characterization, having shown the ability to predict response to stroke treatment,1 but its ability to predict stroke cause and complement machine learning models built from standard clinical features has not been studied.2, 3 The purpose of this study is to evaluate the ability of radiomics features extracted from quantitative magnetic resonance images of retrieved ischemic stroke thrombi (R2*(=1/T2*), …