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Articles 1 - 2 of 2
Full-Text Articles in Medical Specialties
Prediction Of Advanced Fibrosis In Nonalcoholic Fatty Liver Disease: An Enhanced Model Of Bard Score., Tae Hoon Lee, Seung Hye Han, Ju Dong Yang, Donghee Kim, Monjur Ahmed
Prediction Of Advanced Fibrosis In Nonalcoholic Fatty Liver Disease: An Enhanced Model Of Bard Score., Tae Hoon Lee, Seung Hye Han, Ju Dong Yang, Donghee Kim, Monjur Ahmed
Department of Medicine Faculty Papers
UNLABELLED: BACKGROUNDAIMS: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score.
METHODS: One hundred seven patients with biopsy-proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve.
RESULTS: In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate …
Smooth Muscle Fascicular Reorientation Is Required For Esophageal Morphogenesis And Dependent On Cdo., Anthony I Romer, Jagmohan Singh, Satish Rattan, Robert S Krauss
Smooth Muscle Fascicular Reorientation Is Required For Esophageal Morphogenesis And Dependent On Cdo., Anthony I Romer, Jagmohan Singh, Satish Rattan, Robert S Krauss
Department of Medicine Faculty Papers
Postnatal maturation of esophageal musculature involves proximal-to-distal replacement of smooth muscle with skeletal muscle by elusive mechanisms. We report that this process is impaired in mice lacking the cell surface receptor Cdo and identify the underlying developmental mechanism. A myogenic transition zone containing proliferative skeletal muscle precursor cells migrated in a proximal-distal direction, leaving differentiated myofibers in its wake. Distal to the transition zone, smooth muscle fascicles underwent a morphogenetic process whereby they changed their orientation relative to each other and to the lumen. Consequently, a path was cleared for the transition zone, and smooth muscle ultimately occupied only the …