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Full-Text Articles in Medical Specialties
Evaluation Of Etoricoxib In Patients Undergoing Total Knee Replacement Surgery In A Double-Blind, Randomized Controlled Trial., Narinder Rawal, Eugene R. Viscusi, Paul M Peloso, Harold S Minkowitz, Liang Chen, Sandhya Shah, Anish Mehta, Denesh K Chitkara, Sean P Curtis, Dimitris A Papanicolaou
Evaluation Of Etoricoxib In Patients Undergoing Total Knee Replacement Surgery In A Double-Blind, Randomized Controlled Trial., Narinder Rawal, Eugene R. Viscusi, Paul M Peloso, Harold S Minkowitz, Liang Chen, Sandhya Shah, Anish Mehta, Denesh K Chitkara, Sean P Curtis, Dimitris A Papanicolaou
Department of Anesthesiology Faculty Papers
BACKGROUND: Optimal postoperative pain management is important to ensure patient comfort and early mobilization.
METHODS: In this double-blind, placebo- and active-controlled, randomized clinical trial, we evaluated postoperative pain following knee replacement in patients receiving placebo, etoricoxib (90 or 120 mg), or ibuprofen 1800 mg daily for 7 days. Patients >=18 years of age who had pain at rest >=5 (0--10 Numerical Rating Scale [NRS]) after unilateral total knee replacement were randomly assigned to placebo (N = 98), etoricoxib 90 mg (N = 224), etoricoxib 120 mg (N = 230), or ibuprofen 1800 mg (N = 224) postoperatively. Co-primary endpoints included …