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Reproductive and Urinary Physiology Commons™
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- <p>Acetaminophen - Toxicology.</p> <p>Nephrotoxicology.</p> (1)
- Adolescent (1)
- Bottle feeding (1)
- Breast milk (1)
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- Breastfeeding--Economic aspects (1)
- Breastfeeding--Health aspects (1)
- Breastfeeding--Immunological aspects (1)
- Cell Cycle Proteins (1)
- Cell Division (1)
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- Chronic diseases (1)
- Cyclin A (1)
- Cyclin D (1)
- Cyclin-Dependent Kinase Inhibitor p27 (1)
- Cyclin-Dependent Kinase Inhibitor p57 (1)
- Cyclins (1)
- Disease prevention (1)
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- Humans (1)
- Infant feeding (1)
- Kidney Glomerulus (1)
- Male (1)
- Nephrotic Syndrome (1)
- Nuclear Proteins (1)
- Proto-Oncogene Proteins p21(ras) (1)
- Tumor Suppressor Proteins (1)
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Articles 1 - 3 of 3
Full-Text Articles in Reproductive and Urinary Physiology
The Benefits Of Breastfeeding: An Introduction For Health Educators, Sheila G. J. Clark, Timothy J. Bungum
The Benefits Of Breastfeeding: An Introduction For Health Educators, Sheila G. J. Clark, Timothy J. Bungum
Environmental & Occupational Health Faculty Publications
Currently 16% of Americans breastfeed their children for at least 12 months as recommended by the AAP, which is well below the HP 2010 goal of 25%. Breastfed infants receive benefits that can improve their health throughout their lives. The benefits of breastfeeding for children include increased resistance to infectious diseases, such as gastroenteritis, respiratory tract infections, and ear infections. Breastfed children also display lower rates of chronic diseases including diabetes, obesity, asthma, and leukemia. The choice to breastfeed results in economic benefits from lower health care costs and from reduced spending on infant formula. The Healthy People 2010 targets …
Cell-Cycle Regulatory Proteins In Podocyte Cell In Idiopathic Nephrotic Syndrome Of Childhood., Tarak Srivastava, Robert E. Garola, J M. Whiting, Uri S. Alon
Cell-Cycle Regulatory Proteins In Podocyte Cell In Idiopathic Nephrotic Syndrome Of Childhood., Tarak Srivastava, Robert E. Garola, J M. Whiting, Uri S. Alon
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: The podocyte cell is believed to play an important role in idiopathic nephrotic syndrome (INS) of childhood. In adults with cellular and collapsing focal segmental glomerulosclerosis (FSGS), the expression of cell-cycle regulatory proteins such as p27, p57, and cyclin D is decreased and expression of cyclin A, Ki-67, and p21 is observed in podocyte cells suggestive of a dysregulated podocyte phenotype. We investigated for alterations in the expression of cyclin kinase inhibitors, p27, p57, p21, and cyclins D and A in the podocyte cell of children with INS.
METHODS: Forty-two kidney biopsies were investigated; 14 with minimal-change disease (MCD), …
A Mechanistic Study In The Nephrotoxicity Of P-Aminophenol, R. Christopher Harmon
A Mechanistic Study In The Nephrotoxicity Of P-Aminophenol, R. Christopher Harmon
Theses, Dissertations and Capstones
The acetaminophen metabolite, p-aminophenol (PAP), is a known nephrotoxicant. The current study is directed at understanding the mechanism of this nephrotoxicity. Renal cortical slices isolated from F344 rats were incubated with 0 – 0.5 mM PAP with or without pretreatments. Renal slices exposed to PAP showed toxicity as measured by increased lactate dehydrogenase leakage (LDH), decreased pyruvate-stimulated gluconeogenesis, and decreased total adenine nucleotides. There was, however, an increase in ATP as percent of total, implying maintained mitochondrial function. These data show that PAP is directly toxic to renal cortical slices. Pretreatment with EDTA or EGTA provided protection from PAP- induced …