Open Access. Powered by Scholars. Published by Universities.®
Reproductive and Urinary Physiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Adolescent (1)
- Biopsy (1)
- Cell Cycle Proteins (1)
- Child, Preschool (1)
- Cyclin A (1)
-
- Cyclin D (1)
- Cyclin-Dependent Kinase Inhibitor p21 (1)
- Cyclin-Dependent Kinase Inhibitor p27 (1)
- Cyclin-Dependent Kinase Inhibitor p57 (1)
- Cyclins (1)
- Female (1)
- G1 Phase (1)
- Glomerulosclerosis, Focal Segmental (1)
- Humans (1)
- Immunohistochemistry (1)
- Male (1)
- Nephrosis, Lipoid (1)
- Podocytes (1)
- S Phase (1)
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Reproductive and Urinary Physiology
An In Vitro Model Of Ovarian Cancer: Studying The Effects Of Talc And Pycnogenol®, Amber Renée Buz'zard
An In Vitro Model Of Ovarian Cancer: Studying The Effects Of Talc And Pycnogenol®, Amber Renée Buz'zard
Loma Linda University Electronic Theses, Dissertations & Projects
Ovarian cancer is the sixth most common cancer and accounts for more deaths than any other cancer of the female reproductive system. The American Cancer Society has suggested that poor diet, talc and industrial pollutants may increase the risk of developing ovarian cancer. Talc is ubiquitous and concern is raised about its safety, role as a possible carcinogen and known ability to cause irritation and inflammation. Due to the silent nature of ovarian cancer, chemoprevention is a high priority. The most useful chemopreventive compounds will inhibit, delay or reverse carcinogenesis, and can be taken for long periods of time with …
Cell-Cycle Regulatory Proteins In The Podocyte In Collapsing Glomerulopathy In Children., Tarak Srivastava, Robert E. Garola, H K. Singh
Cell-Cycle Regulatory Proteins In The Podocyte In Collapsing Glomerulopathy In Children., Tarak Srivastava, Robert E. Garola, H K. Singh
Manuscripts, Articles, Book Chapters and Other Papers
Podocyte is a terminally committed cell in G1 arrest of cell cycle, and is unable to overcome G1/S transition phase in children with minimal change disease (MCD) and classic focal segmental glomerulosclerosis (FSGS), in contrast to dysregulated proliferative phenotype of idiopathic collapsing glomerulopathy (CGN) in adults. Forty-two kidney biopsies, MCD (14), FSGS (12), CGN (4), and normal (CON) (12), were evaluated by immunohistochemistry using dual staining for expression of p27, p21, and p57, and cyclins D and A, in podocytes of children with CGN. On light microscopy, all podocytes expressed p27, whereas p21 and p57 expression was seen in a …