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Full-Text Articles in Reproductive and Urinary Physiology

Effects Of Dietary Magnesium On Testicular Histology, Steroidogenesis, Spermatogenesis And Oxidative Stress Markers In Adult Rats, Amar K. Chandra, Pallav Sengupta, Haimanti Goswami, Mahitosh Sarkar Dec 2012

Effects Of Dietary Magnesium On Testicular Histology, Steroidogenesis, Spermatogenesis And Oxidative Stress Markers In Adult Rats, Amar K. Chandra, Pallav Sengupta, Haimanti Goswami, Mahitosh Sarkar

Pallav Sengupta, PhD

Magnesium is an essential nutrient that acts as a cofactor in numerous enzymatic reactions including energy metabolism, protein and nucleic acid biosynthesis. Its supplementation has shown to be advantageous in hypertension and treatment of angina. The intricate mechanistic aspects of excess dietary magnesium in testicular morphology and functions have been investigated, as the available information found insufficient. Adult male Wister strain rats were fed magnesium sulphate (MgSO4) with standard diet at diverse doses for one and two consecutive seminiferous cycles (13 and 26 days respectively). Significant increase in the activities of testicular Δ 5 3β - hydroxysteroid dehydrogenase and 17β …

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Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner Oct 2011

Proliferation Of Acid-Secretory Cells In The Kidney During Adaptive Remodelling Of The Collecting Duct, Desa Welsh-Bacic, Marta Nowik, Brigitte Kaissling, Carsten A. Wagner

Desa Welsh

The renal collecting duct adapts to changes in acid-base metabolism by remodelling and altering the relative number of acid or alkali secreting cells, a phenomenon termed plasticity. Acid secretory A intercalated cells (A-IC) express apical H+-ATPases and basolateral bicarbonate exchanger AE1 whereas bicarbonate secretory B intercalated cells (B-IC) express basolateral (and apical) H+-ATPases and the apical bicarbonate exchanger pendrin. Intercalated cells were thought to be terminally differentiated and unable to proliferate. However, a recent report in mouse kidney suggested that intercalated cells may proliferate and that this process is in part dependent on GDF-15. Here we extend these observations to …

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