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Regulation Of Phosphatidylinositol 4-Kinase Iii Alpha Complex Formation In B Cells And Its Role In Autoantibody Production, Michaela M. Sangillo Ms May 2015

Regulation Of Phosphatidylinositol 4-Kinase Iii Alpha Complex Formation In B Cells And Its Role In Autoantibody Production, Michaela M. Sangillo Ms

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The plasma membrane protein Efr3b, the Tetratricopeptide domain repeat 7 (Ttc7), and the kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIa) are found to form a complex a the plasma membrane. This complex is thought to play a role regulating the PI4P pools at the plasma membrane, which is imperative to membrane identity and vesicle transport.