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Development Of A Positron-Emitting Surrogate Microsphere For Image-Based Dosimetry In Yttrium-90 Radioembolization Therapy, Gregory D. Chambers
Development Of A Positron-Emitting Surrogate Microsphere For Image-Based Dosimetry In Yttrium-90 Radioembolization Therapy, Gregory D. Chambers
Nuclear Engineering ETDs
Radioembolization of liver tumors using yttrium-90 (Y-90) labeled microspheres is a proven method of treatment. The primary decay mode of Y-90 is beta-minus decay. The electrons produced during decay deliver a cytotoxic radiation dose in a localized volume. The radiation dose is sufficient to kill tumor cells yet spare the normal liver. The Y-90 microspheres are delivered via a catheter that has been placed in an artery that supplies blood to the tumor. Microspheres are injected and the blood distributes the microspheres. The current practice involves two separate procedures. The first procedure is an assessment of the vasculature of the …