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Mitochondria-Targeted Hydrogen Sulphide Donors Protect Renal Cells From Hypoxia Re-Oxygenation Injury, Ghaleb A. Aboalsamh
Mitochondria-Targeted Hydrogen Sulphide Donors Protect Renal Cells From Hypoxia Re-Oxygenation Injury, Ghaleb A. Aboalsamh
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Abstract
Introduction: Hypoxia re-oxygenation in kidney transplantation affects the outcome. Hydrogen sulphide (H2S), (the newest Gasotransmitter), showed significant protective effect on renal transplantation induced IRI. Our objective was to determine if new mitochondria targeted H2S donor molecule (AP39) would be more efficacious in protecting renal cells against IRI compared to the non-specific H2S donor molecule GYY4137. We hypothesized that AP39 would be more potent.
Methods: in vitro porcine kidney tubular epithelial cells (LCC-PK1) were exposed to warm hypoxia, without treatment (Control), with AP39 or GYY4137 followed by re-oxygenation.
Results: 200nM of AP39 protected the …