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The Antimicrobial Properties Of Exogenous Copper In Human Synovial Fluid Against Staphylococcus Aureus: An In-Vitro Study, Fernando Diaz Dilernia
The Antimicrobial Properties Of Exogenous Copper In Human Synovial Fluid Against Staphylococcus Aureus: An In-Vitro Study, Fernando Diaz Dilernia
Electronic Thesis and Dissertation Repository
We sought to analyse the antimicrobial properties of exogenous copper in human synovial fluid against Staphylococcus aureus. We performed several in-vitro growth and viability assays to determine the capability of multiple S. aureus strains to survive in synovial fluid under different growth conditions. S. aureus UAMS-1 significantly died at 24 hours (p=0.017), and S. aureus USA300 WT survived at 24 hours. We confirmed a high sensitivity to killing with the addition of exogenous copper on both strains at 4 (p=0.011), 12 (p=0.011), and 24 hours (p=0.011). Both WT and CopAZB-deficient USA300 strains significantly died in synovial fluid, evidencing a …