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Developing A Novel Bioink From Hyaluronic Acid-Alginate-Silk Fibroin (Ha- Alg-Sf) For Cartilage 3d Printing, Truc Thanh Nguyen
Developing A Novel Bioink From Hyaluronic Acid-Alginate-Silk Fibroin (Ha- Alg-Sf) For Cartilage 3d Printing, Truc Thanh Nguyen
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the development of a bioink for cartilage 3D printing, Hyaluronic acid (HA), Alginate (Alg) were modified into amine-hyaluronic acid (HA-NH2) and aldehyde alginate (Alg-CHO). Magnetic Nuclear Resonance (NMR) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the successful modification of HA-NH2 and Alg-CHO. The hydrogel HA-Alg was crosslinked as a result of Schiff's base reaction, between primary amines and aldehydes to form imine bonds. By varying volume ratios, the optimal hydrogel HA-Alg (5:5) exhibited its printability, biocompatibility, and functionality as a bioink for cartilage tissue. HA-Alg (5:5) was printable with a custom-made extrusion 3D printer, had slow degradation, shear-thinning behavior, …